2,6-Dichlorophenylacetic acid
- Product Name
- 2,6-Dichlorophenylacetic acid
- CAS No.
- 6575-24-2
- Chemical Name
- 2,6-Dichlorophenylacetic acid
- Synonyms
- 2-(2,6-DICHLOROPHENYL)ACETIC ACID;TIMTEC-BB SBB003503;RARECHEM AL BO 0115;2,6-Dichlorophenyla;Guanfacine Impurity;Guanfacine Impurity 1;2,6-Dichlorphenylessigsure;6-Dichlorophenylacetic acid;2,6-DICHLOROPHENYLACETIC ACID;2,6-DICHLORO BENZENEACETIC ACID
- CBNumber
- CB2481995
- Molecular Formula
- C8H6Cl2O2
- Formula Weight
- 205.04
- MOL File
- 6575-24-2.mol
2,6-Dichlorophenylacetic acid Property
- Melting point:
- 158-161 °C (lit.)
- Boiling point:
- 294.45°C (rough estimate)
- Density
- 1.3806 (rough estimate)
- refractive index
- 1.5490 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.80±0.10(Predicted)
- color
- White to Off-White
- BRN
- 1952744
- InChI
- InChI=1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12)
- InChIKey
- SFAILOOQFZNOAU-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=C(Cl)C=CC=C1Cl
- CAS DataBase Reference
- 6575-24-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,6-Dichlorophenylacetic acid(6575-24-2)
- EPA Substance Registry System
- Benzeneacetic acid, 2,6-dichloro- (6575-24-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-26/37/39-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29163900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 259241
- Product name
- 2,6-Dichlorophenylacetic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $39.2
- Updated
- 2023/06/20
- Product number
- 259241
- Product name
- 2,6-Dichlorophenylacetic acid
- Purity
- 97%
- Packaging
- 100g
- Price
- $149
- Updated
- 2023/06/20
- Product number
- D1897
- Product name
- 2,6-Dichlorophenylacetic Acid
- Purity
- >96.0%(T)
- Packaging
- 25g
- Price
- $133
- Updated
- 2024/03/01
- Product number
- B21354
- Product name
- 2,6-Dichlorophenylacetic acid, 98%
- Packaging
- 5g
- Price
- $22.65
- Updated
- 2024/03/01
- Product number
- B21354
- Product name
- 2,6-Dichlorophenylacetic acid, 98%
- Packaging
- 25g
- Price
- $59.65
- Updated
- 2024/03/01
2,6-Dichlorophenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells.
Preparation
The preparation of the 2, 6-dichlorophenylacetic acid:
the method comprises the following steps: 2, 6-dichlorotoluene is used as a raw material, and is catalyzed by a complex catalyst formed by transition metal and a ligand (wherein, a transition metal catalyst precursor is preferably palladium chloride, an oxidant is preferably TBP (tert-butyl peroxy ether), and a ligand is preferably Xantphos (4, 5-bis (diphenylphosphino) -9, 9-dimethyl xanthene)) in the presence of an alcohol and a catalyst and an oxidant to obtain 2, 6-dichlorophenylacetic acid, and the ethyl 2, 6-dichlorophenylacetate is prepared by hydrolysis and acidification, wherein the total yield is 68.4%. See patent document US2013303798, the reaction procedure is described as synthetic route 1.
In the above synthetic route 1, the preparation process of the intermediate ethyl 2, 6-dichlorophenylacetate requires the use of carbon monoxide for high-temperature and high-pressure reaction, and has poor operation safety, high equipment requirement, high cost, and is not favorable for cost reduction and green production of 2, 6-dichlorophenylacetic acid.
Purification Methods
Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]
2,6-Dichlorophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dichlorophenylacetic acid Suppliers
- Tel
- +91-22-26355700
- Fax
- +91-22-26355701
- info@clearsynth.com
- Country
- India
- ProdList
- 9685
- Advantage
- 58
View Lastest Price from 2,6-Dichlorophenylacetic acid manufacturers
- Product
- 2,6-Dichlorophenylacetic acid 6575-24-2
- Price
- US $614.40/Kg/Drum
- Min. Order
- 1Kg/Bag
- Purity
- 98%
- Supply Ability
- 10tons
- Release date
- 2021-03-23
- Product
- 2,6-Dichlorophenylacetic acid 6575-24-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-25
- Product
- 2,6-Dichlorophenylacetic acid 6575-24-2
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2023-05-15