Boc-L-2,4-diaminobutyric acid
- Product Name
- Boc-L-2,4-diaminobutyric acid
- CAS No.
- 25691-37-6
- Chemical Name
- Boc-L-2,4-diaminobutyric acid
- Synonyms
- BOC-DAB;BOC-DAB-OH;BOC-L-DAB-OH;N-alpha-Ac-Nγ(Tert-Butoxy)Carbonyl Dab-OH;BOC-L-2,4-DIAMINOBUTYRIC ACID;Boc-L-2,4-Dlaminobutyrlc Acid;N?Boc-L-2,4-diaminobutyric acid;Na-Boc-L-2,4-diaminobutyric acid;Nα-Boc-L-2,4-diaminobutyric acid
- CBNumber
- CB2486642
- Molecular Formula
- C9H18N2O4
- Formula Weight
- 218.25
- MOL File
- 25691-37-6.mol
Boc-L-2,4-diaminobutyric acid Property
- Melting point:
- 192-194 °C
- Boiling point:
- 385.5±37.0 °C(Predicted)
- Density
- 1.160±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Methanol (Sparingly), Water (Slightly)
- form
- Powder
- pka
- 3?+-.0.10(Predicted)
- color
- White to off-white
- optical activity
- [α]/D +7.5±1°, c = 1 in methanol: water (1:1)
- BRN
- 4745487
- CAS DataBase Reference
- 25691-37-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A2515
- Product name
- (S)-4-Amino-2-(tert-butoxycarbonylamino)butyric Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A2515
- Product name
- (S)-4-Amino-2-(tert-butoxycarbonylamino)butyric Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $336
- Updated
- 2025/07/31
- Product number
- B657100
- Product name
- Boc-L-2,4-diaminobutyricAcid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 265137
- Product name
- N-alpha-Boc-L-2,4-diaminobutyric acid
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- BAA1087
- Product name
- Boc-L-Dab-OH
- Packaging
- 5G
- Price
- $236.25
- Updated
- 2021/12/16
Boc-L-2,4-diaminobutyric acid Chemical Properties,Usage,Production
Uses
Boc-L-2,4-diaminobutyric acid is a reagent used to synthesize somatostatin antagonist. It can also be used to develop blood coagulation factor Xa inhibitors.
Synthesis
13726-85-7
25691-37-6
General procedure for the synthesis of (S)-4-amino-2-((tert-butoxycarbonyl)amino)butanoic acid from BOC-L-glutamine: to a mixed solution of (S)-5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid (2 g, 8.1 mmol) in DMF and water (1:1, v/v, 18 ml) was added pyridine (1.3 ml, 16.2 mmol). The reaction mixture was stirred at room temperature for 5-10 min. Subsequently, iodobenzene diacetate (3.92 g, 12.1 mmol) was added and the reaction was continued with stirring for 4 hours. After completion of the reaction, deionized water (100 ml) was added to the reaction mixture and extracted with ethyl acetate (3 x 100 ml). The organic phases were combined and washed sequentially with deionized water (100 ml) and saturated saline (100 ml), dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by ether milling and after evaporation of the product grades, 1.1 g (62% yield) of the target compound was obtained as a brown solid. LC-MS analysis showed m/z = 219.1 (M + H).
References
[1] Synthetic Communications, 2004, vol. 34, # 6, p. 1049 - 1056
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 15, p. 4650 - 4656
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 1, p. 161 - 175
[4] Patent: WO2014/151472, 2014, A1. Location in patent: Paragraph 00340-00341
[5] Patent: WO2016/40315, 2016, A1. Location in patent: Paragraph 00383; 00384
Boc-L-2,4-diaminobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
Boc-L-2,4-diaminobutyric acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from Boc-L-2,4-diaminobutyric acid manufacturers
- Product
- Boc-Dab-OH 25691-37-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2023-09-18
- Product
- Boc-L-2,4-diaminobutyric acid 25691-37-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04