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Remoxipride

Product Name
Remoxipride
CAS No.
80125-14-0
Chemical Name
Remoxipride
Synonyms
Roxiam;FLA-731;A-33547;REMOXIPRIDE;(S)-Remoxipride;Remoxipride [USAN:BAN:INN];(S)-3-Bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2，6-dimethoxybenzamide;(S)-3-BroMo-N-((1-ethylpyrrolidin-2-yl)Methyl)-2,6-diMethoxybenzaMide;3-Bromo-2,6-dimethoxy-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]benzamide;3-Bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide
CBNumber
CB2493967
Molecular Formula
C16H23BrN2O3
Formula Weight
371.27
MOL File
80125-14-0.mol
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Remoxipride Property

alpha 
D20 -64° (c = 2 in ethanol)
Boiling point:
439.9±45.0 °C(Predicted)
Density 
1.292
storage temp. 
2-8°C
pka
pKa 8.9 (Uncertain)
CAS DataBase Reference
80125-14-0(CAS DataBase Reference)
NIST Chemistry Reference
Remoxipride(80125-14-0)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009206
Product name
REMOXIPRIDE
Purity
95.00%
Packaging
1G
Price
$1725.15
Updated
2021/12/16
Chemenu
Product number
CM197831
Product name
(S)-3-bromo-N-((1-ethylpyrrolidin-2-yl)methyl)-2,6-dimethoxybenzamide
Purity
95%
Packaging
1g
Price
$893
Updated
2021/12/16
AHH
Product number
MT-58413
Product name
Remoxipride
Purity
98%
Packaging
0.1g
Price
$910
Updated
2021/12/16
Crysdot
Product number
CD31000764
Product name
Remoxipride
Purity
95+%
Packaging
1g
Price
$947
Updated
2021/12/16
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Remoxipride Chemical Properties,Usage,Production

Uses

Antipsychotic.

Definition

ChEBI: 3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide is a dimethoxybenzene.

General Description

Remoxipride is a D2 receptorblocker.It is as effective as haloperidol with fewer EPS andautonomic side effects. Negative symptoms of schizophreniaare diminished. The drug is classed as an atypical antipsychotic.Life-threatening aplastic anemia was reported with itsuse, which prompted its withdrawal from the market.
With respect to the atypical antipsychotics, two eventslong in the past may shed some light on the events of today.
The field of reuptake-inhibiting antidepressants arose whenonly a very small structural change was made in an antipsychoticdrug, and the new activity noted. (The antipsychoticactivity remained.) Therefore, small changes in structurecan produce antipsychotics that are active against depressivesymptoms. Likewise, small changes in structure could provideselectivity among D2 receptors.

in vivo

(S)-Remoxipride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1]. (S)-Remoxipride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.1-100 μM/kg
Administration:Intraperitoneal injection; 0.1-100 μM/kg; 60 min prior to apomorphine
Result:Blocked apomorphine-induced hyperactivity and dose-dependent blockaded apomorphine-induced behaviors in vivo.
Animal Model:Male and female beagle dogs[1]
Dosage:0.25-5 μM/kg
Administration:Oral gavage; 0.25-5 μM/kg; 60 min prior to apomorphine
Result:Blocked apomorphine-induced vomiting in dogs.

IC 50

D2 Receptor: 1.57 μM (IC50); D1 Receptor: ＞100 μM (IC50); α1-Adrenoccptor: 42 μM (IC50)

Remoxipride Preparation Products And Raw materials

Raw materials

2,6-Dimethoxybenzoic acid 2-(Aminomethyl)-1-ethylpyrrolidine Thionyl chloride

Preparation Products

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Remoxipride Suppliers

China 9 Europe 1 Germany 1 United Kingdom 5 United States 13 Global 29
TargetMol Chemicals Inc.
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Alfa Chemistry
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ChemPacific Corporation
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80125-14-0, RemoxiprideRelated Search:

Kresoxim-methyl Methylparaben p-(2-Methoxyethyl) phenol Methyl acrylate Methanol Benzamide Basic Violet 1 3-Bromoanisole Methyl acetate Chlorantraniliprole Paraquat dichloride Acetonitrile Methyl 3-BROMO-2-METHOXYBENZALDEHYDE 3-Bromo-N-butylbenzamide 5-Bromo-2-chlorobenzoic acid BENZAMIDE, N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-HYDROXY-6-METHOXY-, (S)- N-(5-BROMO-2-METHOXYBENZYL)-N-METHYLAMINE

  • REMOXIPRIDE
  • (S)-Remoxipride
  • 3-Bromo-2,6-dimethoxy-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]benzamide
  • 3-Bromo-2,6-dimethoxy-N-[[[2S,(-)]-1-ethylpyrrolidine-2α-yl]methyl]benzamide
  • 3-Bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide
  • (S)-3-BroMo-N-((1-ethylpyrrolidin-2-yl)Methyl)-2,6-diMethoxybenzaMide
  • A-33547
  • FLA-731
  • Roxiam
  • Remoxipride [USAN:BAN:INN]
  • (S)-3-Bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2，6-dimethoxybenzamide
  • 3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxy-benzamide
  • Benzamide,3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxy-
  • 80125-14-0
  • C16H20BrN2O3