2-Fluoro-4-nitrophenol
- Product Name
- 2-Fluoro-4-nitrophenol
- CAS No.
- 403-19-0
- Chemical Name
- 2-Fluoro-4-nitrophenol
- Synonyms
- 2-Fluoro-4-nitro;5-Fluoro-2-nitrophen;4-nitro-2-fluorophenol;2-Fluoro-4-nitrophenol;o-fluoro-4-nitrophenol;4-nitro-o-fluorophenol;2-Fluoro-4-nitrophenol>Phenol, 2-fluoro-4-nitro-;2-Fluoro-4-nitrophenol,99%;2-Fluoro-4-nitrophenol 98%
- CBNumber
- CB2500605
- Molecular Formula
- C6H4FNO3
- Formula Weight
- 157.1
- MOL File
- 403-19-0.mol
2-Fluoro-4-nitrophenol Property
- Melting point:
- 120-122 °C (lit.)
- Boiling point:
- 281.2±25.0 °C(Predicted)
- Density
- 1.4306 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 5.67±0.22(Predicted)
- color
- White to Light yellow
- BRN
- 1944995
- InChI
- InChI=1S/C6H4FNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H
- InChIKey
- ORPHLVJBJOCHBR-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C([N+]([O-])=O)C=C1F
- CAS DataBase Reference
- 403-19-0(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Fluoro-4-nitrophenol (403-19-0)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29089000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 345067
- Product name
- 2-Fluoro-4-nitrophenol
- Purity
- 99%
- Packaging
- 1g
- Price
- $27.3
- Updated
- 2022/05/15
- Product number
- F0381
- Product name
- 2-Fluoro-4-nitrophenol
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $18
- Updated
- 2025/07/31
- Product number
- F0381
- Product name
- 2-Fluoro-4-nitrophenol
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- F597625
- Product name
- 2-Fluoro-4-nitrophenol
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 002596
- Product name
- 2-Fluoro-4-nitrophenol
- Purity
- 99%
- Packaging
- 100g
- Price
- $72
- Updated
- 2021/12/16
2-Fluoro-4-nitrophenol Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
2-Fluoro-4-nitrophenol may be used in chemical synthesis.
General Description
2-Fluoro-4-nitrophenol is a derivative of m-fluoronitrobenzene. Crystal structure of complex of α-cyclodextrin with 2-fluoro-4-nitrophenol has been studied by the X-ray diffraction technique.
Synthesis
367-12-4
7440-44-0
1526-17-6
403-19-0
A. Synthesis of 2-fluoro-4-nitrophenol 2-Fluorophenol (32.3 g, 0.288 mol) was dissolved in dichloromethane under ice-salt bath conditions and cooled to -10 °C. 90% nitric acid (22 g, 0.31 mol HNO3) was added slowly, and the titration rate was controlled to maintain the reaction temperature at about -5 °C, and the titration process lasted for 1 hour. After completion of the dropwise addition, the reaction mixture was continued to be stirred at 0°C for 1 hour. At the end of the reaction, the precipitate was collected by filtration and washed several times with cold dichloromethane. Analysis by GC and thin layer chromatography (silica gel, 7:3 hexane-acetone) showed that the product was mainly a single compound and the by-products generated in the reaction were of low polarity and volatility. The solid was dissolved in ether, washed with water, dried over anhydrous magnesium sulfate, and the solvent evaporated. The resulting solid was recrystallized with methylcyclohexane to give 13 g of a pale yellow solid with a melting point of 119°-121°C. Nuclear magnetic resonance (CDCl3) analysis confirmed that the product was 2-fluoro-4-nitrophenol. B. Isolation of 2-fluoro-6-nitrophenol The dichloromethane mother liquor was washed with water, dried over anhydrous magnesium sulfate and the solvent was evaporated. The resulting solid was ground with boiling hexane (3 x 150 ml) to effectively remove the least polar and volatile by-products. The hexane solution was treated with activated carbon, filtered and concentrated to about 300 ml, and cooled to give 13.5 g (30% yield) of 2-fluoro-6-nitrophenol as a yellow solid with a melting point of 70°-86° C. The solid was then dried with water.
References
[1] Patent: US4750931, 1988, A
[2] Patent: EP142328, 1991, B1
2-Fluoro-4-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-4-nitrophenol Suppliers
- Tel
- --
- Fax
- --
- sales@riccichimica.com
- Country
- Italy
- ProdList
- 2146
- Advantage
- 46
View Lastest Price from 2-Fluoro-4-nitrophenol manufacturers
- Product
- 2-Fluoro-4-nitrophenol 403-19-0
- Price
- US $40.00-30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-03-26
- Product
- 2-Fluoro-4-Nitrophenol 403-19-0
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- 2-Fluoro-4-nitrophenol 403-19-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11