5,6-Dichloro-2-benzothiazolamine
- Product Name
- 5,6-Dichloro-2-benzothiazolamine
- CAS No.
- 24072-75-1
- Chemical Name
- 5,6-Dichloro-2-benzothiazolamine
- Synonyms
- 5,6-dichloro-2-benzothiazolamin;5,6-dichlorobenzothiazol-2-amine;2-AMINODICHLOROBENZOTHIAZOLE,98%;5,6-Dichloro-2-benzothiazolamine;2-Amino-5,6-dichlorobenzothiazole;2-Benzothiazolamine, 5,6-dichloro-;5,6-Dichlorobenzo[d]thiazol-2-amine;5,6-Dichloro-1,3-benzothiazol-2-amine;2-Benzothiazolamine,5,6-dichloro-(9CI);TIANFU CHEM--5,6-Dichloro-2-benzothiazolamine
- CBNumber
- CB2504739
- Molecular Formula
- C7H4Cl2N2S
- Formula Weight
- 219.09
- MOL File
- 24072-75-1.mol
5,6-Dichloro-2-benzothiazolamine Property
- Melting point:
- 175-180°C
- Boiling point:
- 379.7±45.0 °C(Predicted)
- Density
- 1.654±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.79±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- Water Solubility
- <0.1 g/100 mL at 17 ºC
- CAS DataBase Reference
- 24072-75-1(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Amino-5,6-dichlorobenzothiazole (24072-75-1)
Safety
- Safety Statements
- 24/25
- HS Code
- 29342000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A632080
- Product name
- 2-Amino-5,6-dichlorobenzothiazole
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A632080
- Product name
- 2-Amino-5,6-dichlorobenzothiazole
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- L179
- Product name
- 2-Amino-5,6(6,7)-dichlorobenzothiazole,1:1mixture
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 7H70-5-1G
- Product name
- 2-Amino-5,6-dichlorobenzothiazole
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $226
- Updated
- 2021/12/16
- Product number
- AS147553
- Product name
- 5,6-Dichlorobenzo[d]thiazol-2-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
5,6-Dichloro-2-benzothiazolamine Chemical Properties,Usage,Production
Chemical Properties
White powder
General Description
White solid or powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated organosulfide and an amine. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
Flash point data for 5,6-Dichloro-2-benzothiazolamine are not available. 5,6-Dichloro-2-benzothiazolamine is probably combustible.
Synthesis
333-20-0
95-76-1
24072-75-1
To a solution of acetic acid (160 mL) containing 3,4-dichloroaniline (10 g, 62 mmol) and potassium thiocyanate (48 g, 0.49 mol), a solution of acetic acid (160 mL) with liquid bromine (31 g, 0.19 mol) was slowly added at 0 °C, while stirring was maintained. The reaction temperature was maintained at 0 °C throughout the addition. After addition, the reaction mixture was continued to be stirred at 0 °C for 2 h, and then warmed up to 15 °C for 14 h. The reaction temperature was kept constant at 0 °C for 2 h. The reaction temperature was kept constant at 15 °C for 2 h. Upon completion of the reaction, the reaction solution was diluted with water (100 mL), the pH was adjusted to 7-8 with ammonium hydroxide, and then extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed with brine (3 x 300 mL) and subsequently concentrated under reduced pressure. The crude product was purified by preparative HPLC [Apparatus: GX-B; Column: GEMINI 250 × 50 mm, particle size: 10 μm; Mobile phase: 25-50% acetonitrile in water (containing 0.1% TFA, v/v)] to afford the target compound 5,6-dichlorobenzo[d]thiazol-2-amine (2.6 g, 19% yield) as a white solid.LCMS ( ESI): tR = 0.694min, m/z (M+H)+ 219.0. 1H-NMR (CD3OD, 400MHz): δ 7.89 (s, 1H), 7.55 (s, 1H).
References
[1] Patent: WO2017/69980, 2017, A1. Location in patent: Paragraph 00319; 00320
[2] Bioorganic Chemistry, 2016, vol. 67, p. 130 - 138
5,6-Dichloro-2-benzothiazolamine Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-Dichloro-2-benzothiazolamine Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 0531-88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9858
- Advantage
- 58
View Lastest Price from 5,6-Dichloro-2-benzothiazolamine manufacturers
- Product
- 5,6-Dichloro-2-benzothiazolamine 24072-75-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21