Overview Indication Mode of action Pharmacokinetics Adverse reactions Precaution Referrence
ChemicalBook > CAS DataBase List > Hydroxyzine

Hydroxyzine

Overview Indication Mode of action Pharmacokinetics Adverse reactions Precaution Referrence
Product Name
Hydroxyzine
CAS No.
68-88-2
Chemical Name
Hydroxyzine
Synonyms
Atara;Atarox;Aterax;NP 212;Tran-Q;Atarax;Atazina;Deinait;UCB 492;Pamazone
CBNumber
CB2547530
Molecular Formula
C21H27ClN2O2
Formula Weight
374.9
MOL File
68-88-2.mol
More
Less

Hydroxyzine Property

Melting point:
190°C
Boiling point:
250 °C(Press: 0.1 Torr)
Density 
1.1020 (rough estimate)
refractive index 
1.5400 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly,
form 
Oil to Gel
pka
pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)
color 
Colourless to Yellow
Water Solubility 
< 700 mg/mL
BCS Class
2
NIST Chemistry Reference
Hydroxyzine base(68-88-2)
EPA Substance Registry System
Hydroxyzine (68-88-2)
More
Less

Safety

Hazardous Substances Data
68-88-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 840mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H336May cause drowsiness or dizziness

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P285In case of inadequate ventilation wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
24039
Product name
Hydroxyzine
Purity
≥98%
Packaging
100mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
24039
Product name
Hydroxyzine
Purity
≥98%
Packaging
250mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
24039
Product name
Hydroxyzine
Purity
≥98%
Packaging
500mg
Price
$291
Updated
2024/03/01
TRC
Product number
H996495
Product name
Hydroxyzine
Packaging
500mg
Price
$145
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000603
Product name
HYDROXYZINE
Purity
95.00%
Packaging
500MG
Price
$872
Updated
2021/12/16
More
Less

Hydroxyzine Chemical Properties,Usage,Production

Overview

Hydroxyzine hydrochloride, a member of the piperazine class of H1 receptor antagonists[1] is a strong antipruritic and anti-whealing[2-4] agent and is often recommended as the antihistamine of choice in the treatment of allergic skin disorders[5-7]. It is also effective in the treatment of allergic rhinitis[8, 9] and has some bronchodilator properties when used alone or in combination with other bronchodilators[10-12].
Like other "classic H, antihistamines," the central nervous system(CNS) effects of hydroxyzine are well appreciated and can at times make the daytime treatment of allergic conditions difficult. The most common CNS side effect of hydroxyzine is sedation, and probably an actual impairment of cognitive function, because most studies use psychomotor testing to quantitate these CNS effects[13, 14]. The pharmacologic mechanism for this CNS effect remains poorly understood. Much interest has been paid to the development of "nonsedating" antihistamines. There had been frequent claims of relatively less sedation, but in many cases such studies do not demonstrate that doses devoid the CNS effects are capable of producing adequate antiallergic effects. Recent data with newer agents challenge the long-held concept that sedation was an inseparable component of classic antihistaminic effects. These newer agents tend to have a smaller volume of distribution (Varea) in the body, and some suggest that lower CNS penetration is responsible for the lower incidence of CNS effects.

Figure 1 Chemical structure of hydroxyzine

Indication

Hydroxyzine is used for the treatment of anxiety disorder as well as being used in other more serious cases as psychoneurosis. Therefore, it is prescribed as a means of regulating normal function. Hydroxyzine has shown to be as effective as the benzodiazepine drug bromazepam in the treatment of generalised anxiety disorder[15]. A systematic review found that hydroxyzine is as excellent as other anxiolytic agents[benzodiazepines and buspirone] in efficacy, acceptability, and tolerability[16]. Hydroxyzine can also be used for the treatment of allergic conditions including chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus. Studies have found no adverse effects on the liver, blood, nervous system, or urinary tract[17].

Mode of action

Hydroxyzine taking effect through acting as the competitor of histamine for binding at H1-receptor sites on the effector cell surface, further leading to suppression of histaminic edema, flare, and pruritus[18]. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may also be effective as an antiemetic. Since hydroxyzine has very low affinity for the muscarinic acetylcholine receptors, it has low or no propensity for producing anticholinergic side effects[19][20][21]. In addition to its antihistamine activity, hydroxyzine is also capable of acting more weakly as an antagonist of the serotonin 5-HT2A receptor, the dopamine D2 receptor, and the α1-adrenergic receptor[22]. The weak antiserotonergic effects of hydroxyzine likely underlie its usefulness as an anxiolytic,[23] as other antihistamines without such properties have not been found to be effective in the treatment of anxiety[24].

Pharmacokinetics

Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, being for the treatment of histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine can also be used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist. The 0.7-mg/kg oral dose of hydroxyzine produced a mean peak serum concentration of 72.5 mg/ml at a mean time of 2.1 hr. The mean elimination half-life calculated from the terminal linear portion of the curves was 20.0 hr. The mean clearance rate, 9.78 ml/min/kg, and mean apparent volume of distribution, 16.0 L/kg, were also calculated by nonparametric methods.
In a study of the disposition of tritiated hydroxyzine in rats, 40% to 42% of the radioactivity was excreted within 24 hr, largely in the feces via the bile and in the urine. Hydroxyzine was rapidly distributed to all organs studied, with the highest activity being found in the lungs, fat, liver, spleen, and kidneys. The drug appeared to be completely metabolized, since less than 2% of the radioactivity as unchanged drug was recovered in the urine or feces. About 16% of the dose of radioactivity was recovered in urine over 5 days. Of this, 7% was identified as p-chlorobenzophenone, p-chlorobenzhydrol, and p-chlorop’-hydroxybenzophenone, 15% as pchlorobenzhydrol and p-chloro-p’-hydroxybenzophenone glucuronides, and 5% as piperazine and 2-[2-[1-piperazinyl]-ethoxyl] ethanol[25].

Adverse reactions

Several side effects including deep sleep, incoordination, sedation, calmness, and dizziness have been reported in children and adults, as well as others such as hypotension, tinnitus, and headaches[27]. Gastrointestinal effects have also been observed, as well as less serious effects such as dryness of the mouth and constipation caused by the mild antimuscarinic properties of hydroxyzine[27].
Adverse reactions may also occur rarely to central nervous system including hallucinations or confusion, being attributed mostly to overdosage[27, 28]. Such properties have been attributed to hydroxyzine in several cases, particularly in patients treated for neuropsychological disorders, as well as in cases where overdoses have been observed. While there are reports of the "hallucinogenic" or "hypnotic" properties of hydroxyzine, several clinical data trials have not reported such side effects from the sole consumption of hydroxyzine, but rather, have described its overall calming effect described through the stimulation of areas within the formatio reticularis. The hallucinogenic or hypnotic properties have been described as being an additional effect from overall central nervous system suppression by other CNS agents, such as lithium or ethanol[29].

Precaution

The following tips should be following when you use hydroxyzine[30]. You should not use hydroxyzine in the following conditions, allergic to it/ you have long QT syndrome/ you are allergic to cetirizine(Zyrtec) or levocetirizine(Xyzal) you are in the first trimester of pregnancy. You should not use hydroxyzine if you are pregnant, especially during the first or second trimester. Hydroxyzine could harm the unborn baby or cause birth defects. You should use effective birth control to prevent pregnancy while you are using this medicine.
To make sure this medicine is safe for you, tell your doctor if you have: blockage in your digestive tract(stomach or intestines) bladder obstruction or other urination problems/ glaucoma/heart disease/slow heartbeats/personal or family history of long QT syndrome/ an electrolyte imbalance(such as high or low levels of potassium in your blood)/ if you have recently had a heart attack. It is not known whether hydroxyzine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Do not give this medicine to a child without medical advice.

Referrence

  1. Rhoades RB, Leifer KN, Cohan R, Wittig HJ: Suppression of histamine-induced pruritus by three antihistaminic drugs. J ALLERGY CLIN IMMUNOL 55:180, 1975
  2. Cook TJ, MacQueen DM, Wittig HJ, Thomby Jl, Lantos RL, Virtue CM: Degree and duration of skin test suppression and side effects with antihistamines. J ALLERGY CLIN IMMUNOL 51:71, 1973
  3. Dundas E, Toogood JH, Wanklin J: Inhibition of experimental skin wheal by some ataractic and antihistaminic drugs. J ALLERGY 32:1, 1961
  4. Galant SP, Bullock J, Wong D, Maibach HI: The inhibitory effect of antiallergy drugs on allergen and histamine induced wheal and flare response. J ALLERGY CLIN IMMUNOL 51:ll.1973
  5. Baraf CS: Treatment of pruritus in allergic dennatoses: an evaluation of the relative efficacy of cyproheptadine and hydroxyzine. Curr Ther Res 19:32, 1976
  6. Klein GL, Galant SP: A comparison of the antipruritic efficacy of hydroxyzine and cyproheptadine in children with atopic dermatitis. Ann Allergy 44:142, 1980
  7. Matthews CNA, Kirby JD, James J, Warin RP: Dermographism: reduction in weal size by chlorpheniramine and hydroxyzine. Br J Dermatol 88:279, 1973
  8. Schaaf L, Hendeles L, Weinberger M: Suppression of seasonal allergic rhinitis symptoms with daily hydroxyzine. J ALLERGY CLIN IMMUNOL 63:129, 1979
  9. Wong L, Hendeles L, Weinberger M: Pharmacologic prophylaxis of allergic rhinitis: relative efficacy of hydroxyzine and chlorpheniramine. J ALLERGY CLIN IMMUNOL 67:223, 1981
  10. Bierman CW, Pierson WE, Shapiro GG: Exercise-induced asthma. Pharmacological assessment of single drugs and drug combinations. JAMA 234295, 1975
  11. Heurich A, Sousa-Poza M, Lyons HA: Bronchodilator effects of hydroxyzine hydrochloride. Respiration 29:135, 1972
  12. Brandon ML: Pirbuterol vs hydroxyzine vs theophylline vs placebo in the treatment of bronchial asthma. Ann Allergy 45:8, 1980
  13. Burns M, Moskowitz H. Effects of diphenhydramine and alcohol on skills performance. Eur J Clin Pharmacol 1980;17:259-66.
  14. Seppala T, Nuotto E, Korttila K. Single and repeated dose comparison of three antihistamines and phenylpropanolamine psychomotor performance and subjective appraisal of sleep. Br J Clin Pharmacol 1981;12:179-88.
  15. Llorca PM, Spadone C, Sol O, et al.[November 2002]. "Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study". J Clin Psychiatry. 63[11]: 1020–7.
  16. Giuseppe Guaiana1, Corrado Barbui, Andrea Cipriani[8 December 2010]. "Hydroxyzine for generalised anxiety disorder". The Cochrane Library. Cochrane Depression, Anxiety and Neurosis Group.
  17. United States Food & Drug Administration,[2004], p1
  18. https://www.drugbank.ca/drugs/DB00557
  19. Hosák, Ladislav; Hrdli?ka, Michal. Psychiatry and Pedopsychiatry. Charles University in Prague, Karolinum Press. pp. 364–. ISBN 978-80-246-3378-7.
  20. Berger, F. M.[1957]. "THE CHEMISTRY AND MODE OF ACTION OF TRANQUILIZING DRUGS". Annals of the New York Academy of Sciences. 67[10]: 685–700. doi:10.1111/j.1749-6632.1957.tb46006.x. ISSN 0077-8923.
  21. K. D. Tripathi[2013]. Essentials of Medical Pharmacology. JP Medical Ltd. p. 165. ISBN 978-93-5025-937-5.
  22. J. Szepietowski; E. Weisshaar. Itch Management in Clinical Practice. Karger Medical and Scientific Publishers. pp. 1–. ISBN 978-3-318-05889-5.
  23. Barbara Olasov Rothbaum; Stein, Dan J.; Hollander, Eric[2009]. Textbook of Anxiety Disorders. American Psychiatric Publishing, Inc. ISBN 1-58562-254-0.
  24. Lamberty Y, Gower AJ. "Hydroxyzine prevents isolation-induced vocalization in guinea pig pups: comparison with chlorpheniramine and immepip". Pharmacology Biochemistry and Behavior. 79[1]: 119–24. doi:10.1016/j.pbb.2004.06.015. PMID 15388291.
  25. Pong S F, Huang C L. Comparative studies on distribution, excretion, and metabolism of hydroxyzine-3H and its methiodide-14C in rats[J]. Journal of Pharmaceutical Sciences, 1974, 63[10]:1527-1532.
  26. Fouda H G, Hobbs D C, Stambaugh J E. Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics[J]. Journal of Pharmaceutical Sciences, 2010, 68[11]:1456-1458.
  27. UCB South-Africa, et al.,[2004]
  28. United States Food & Drug Administration,[2004], p3
  29. Anderson, P. O., Knoben, J. E., et al.[2002], p794-796
  30. https://www.drugs.com/hydroxyzine.html

Description

Hydroxyzine is an antihistamine drug with M-cholinoblocking properties and expressed action on the CNS. It suppresses subcortical regions of the CNS including the limbic system and reticular formation. It potentiates the effect of narcotic analgesics and exhibits sedative effects.

Chemical Properties

Yellow Oil

Originator

Atarax,UCB,France,1956

Uses

H1 receptor antagonist. Anxiolytic. Antihistaminic.

Uses

It is used as a sympthomatic drug for atopic dermatitis as a sedative drug before and after operational interventions, for preventing vomiting and diarrhea, and for relieving agitation and emotional disorders. Synonyms of this drug are atarax, durrax, and vistaril.

Uses

Hydroxyzine is intended for the symptomatic treatment of anxiety and stress associated with neurosis as well as with conditions of organic illness. This drug has muscle relaxant, antihistimine, analgesic, local anesthetic, and antiemetic action as well as a wide therapeutic effect. It is mainly used in premedication and following general anesthesia, during which it potentiates the action of meperidine and barbiturates. It is frequently used in pediatrics as a mild sedative drug.

Definition

ChEBI: A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.

Indications

Drugs of choice for the treatment of dermatographism and cholinergic urticaria. They are also effective alone or in combination with other antihistamines in the management of acute and chronic urticaria, atopic and contact dermatoses, and histamine-induced pruritus. It may be used alone or with other antihistamines, and dosage should be pushed to the limit of tolerance or to subsidence of symptoms.

Manufacturing Process

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.

brand name

Amplimexon (Amplimed).

Therapeutic Function

Tranquilizer

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

Synthesis

Hydroxyzine, 2-[2-[4-(p-chloro-|á-phenylbenzyl)-1-piperazinyl]-ethoxy] ethanol (5.2.6), is synthesized by the alkylation of 1-(4-chlorobenzohydril)piperazine with 2-(2-hydroxyotoxy)ethylchloride [56¨C61].

Dosage forms

25 mg, three to four times a day.

Hydroxyzine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Hydroxyzine Suppliers

Canada 1 China 54 Europe 2 India 7 United States 21 Global 85
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3254
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
Baoji Guokang Bio-Technology Co., Ltd.
Tel
0917-3909592 13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9310
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49476
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29809
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038; 18501792038
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
Advantage
58
Nanjing shengyilai Chemical Co., Ltd
Tel
19951936396
Email
3158688292@qq.com
Country
China
ProdList
4856
Advantage
58
Qingdao haohai anjie pharmaceutical technology co., ltd.
Tel
156-6622-8711 18639325623
Email
chen.wanglin@hmgj.group
Country
China
ProdList
1905
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81024372 15029046529
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10010
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31121
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
18902340307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9244
Advantage
58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10623
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
0755-66853366; 13670046396
Email
ORDERS@QCSRM.COM
Country
China
ProdList
24342
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
30016
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
17730
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Hubei Enxing Biotechnology Co., Ltd
Tel
16621771607
Email
exbio_tech@163.com
Country
China
ProdList
8189
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
Zhengzhou JACS Chemical Product Co., LTD
Tel
0371-86259281 13223061139
Email
893596907@qq.com
Country
China
ProdList
7973
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
73043
Advantage
58
Tel
18153089275
Email
3032079623@qq.com
Country
China
ProdList
22695
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 13308200041
Email
2851167782@qq.com
Country
China
ProdList
11183
Advantage
58
Tel
Email
sangon@qq.com
Country
CHINA
ProdList
47239
Advantage
58
Henan Tianfu Chemical Co.,Ltd.
Tel
+86-0371-55170693 +86-19937530512
Fax
0371-55170693
Email
info@tianfuchem.com
Country
China
ProdList
21632
Advantage
55
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel
+8613817748580
Fax
021-50175322
Email
cooperation@kean-chem.com
Country
China
ProdList
40066
Advantage
58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+86-18621343501; +undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33338
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43340
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49982
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6682
Advantage
58
Biorbyt Ltd.
Tel
--
Fax
--
Email
info@biorbyt.com
Country
CHINA
ProdList
6579
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Yann Pharmachem Co., Ltd
Tel
--
Fax
--
Country
China
ProdList
61
Advantage
38
More
Less

View Lastest Price from Hydroxyzine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Hydroxyzine 68-88-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Hydroxyzine 68-88-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Hydroxyzine 68-88-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

68-88-2, HydroxyzineRelated Search:

Decloxizin HCL CP2000 HYDROXYZINE HYDROCHLORIDE,HYDROXYZINE DIHYDROCHLORIDE Levocetirizine Etodroxizine Hydroxyzine Cetirizine dihydrochloride Cetirizine Decloxizine HYDROXYZINE HYDROCHLORIDE 4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/CetirizineEp (S)-Cetirizine Hydroxyzine-D8 Dihydrochloride CETIRIZINE N-OXIDE hydroxyzine monohydrochloride 2-Naphthoic acid, 4,4'-methylenebis[3-hydroxy-, hydroxyzine salt (6CI),hydroxyzine embonate,HYDROXYZINE PAMOATE SALT,HYDROXYZINE PAMOATE Hydroxyzine-d8 See: H996502,Hydroxyzine-D8 HYDROXYZINE HCL Hydroxyzine pamoate (ester)

  • 1-(p-Chloro-a-phenylbenzyl)-4-[2-(2-hydroxyethoxy)ethyl)]piperazine
  • NSC 169188
  • 1-(p-Chloro-α-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine
  • 2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol
  • Ethanol, 2-[2-[4-(4-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (6CI)
  • Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (8CI)
  • Hydroxyzine (base and/or unspecified salts)
  • EQUIPOISE / HYDROXYZINE
  • Atarazoid
  • Atarox
  • Atazina
  • Aterax
  • Deinait
  • Equipoise
  • Ethanol, 2-[2-[4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl]ethoxy]-
  • Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • Hychotine
  • Hydroksyzyny
  • Hydroxine
  • Hydroxizine
  • Hydroxycine
  • Hydroxyzin
  • Hydroxyzyne
  • Idrossizina
  • N-(4-Chlorobenzhydryl)-N'-(hydroxyethoxyethyl)piperazine
  • neo-Calma
  • Neurozina
  • Nevrolaks
  • NP 212
  • Pamazone
  • Parenteral
  • Paxistil
  • Placidol
  • Plaxidol
  • Tran-Q
  • Tranquizine
  • Traquizine
  • U.C.B 4492
  • U.CB 4492
  • UCB 492
  • UCB-4492
  • Vesparaz-Wirkstoff
  • Vistaril
  • 2-(2-(4-(4-chlorobenzhydryl)piperazin-1-yl)ethoxy)ethanol
  • HYDROXYZINE;NSC 169188;U.C.B 4492
  • 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine
  • 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine
  • 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
  • 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
  • 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol
  • 2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol
  • Atara
  • Atarax
  • Atarax base
  • Ataraxoid
  • 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyet
  • 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)-piperazin-1-yl)ethoxy)etha
  • Hydroxyzine