UFD1 Antibody
Source Reactivity Background References- Product Name
- UFD1 Antibody
- Chemical Name
- UFD1 Antibody
- Synonyms
- UFD1 Antibody
- CBNumber
- CB25761456
- Formula Weight
- 0
- MOL File
- Mol file
UFD1 Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The ubiquitin fusion degradation 1 adaptor protein is a component of a protein complex essential for degradation of misfolded proteins by the endoplasmic reticulum-associated protein degradation pathway. The UFD1 protein contains a pair of conserved, amino-terminal ubiquitin-binding sites responsible for binding mono- and polyubiquitin molecules. The carboxy-terminal region of UFD1 contains binding sites for both the adapter protein NPL4 and the AAA ATPase VCP. The UFD1-NPL4 heterodimer binds VCP to create a protein complex responsible for export of misfolded proteins from the ER to the cytoplasm for ubiquitin-mediated degradation. The same protein complex may also be involved in disassembly of the spindle apparatus following mitosis.
References
[1] Ye, Y. et al. (2001) Nature 414, 652-6.
[2] Ye, Y. et al. (2003) J Cell Biol 162, 71-84.
[3] Park, S. et al. (2005) Structure 13, 995-1005.
[4] Bruderer, R.M. et al. (2004) J Biol Chem 279, 49609-16.
[5] Meyer, H.H. et al. (2000) EMBO J 19, 2181-92.
[6] Meyer, H.H. et al. (2002) EMBO J 21, 5645-52.
[7] Pye, V.E. et al. (2007) Proc Natl Acad Sci U S A 104, 467-72.
[8] Cao, K. and Zheng, Y. (2004) Cell Cycle 3, 422-4.
UFD1 Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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