UCPH-101
- Product Name
- UCPH-101
- CAS No.
- 1118460-77-7
- Chemical Name
- UCPH-101
- Synonyms
- CS-2757;UCPH-101;UCPH-101 ，S0297;UCPH-101, 10 mM in DMSO;UCPH-101; UCPH 101; UCPH101;inhibit,UCPH101,UCPH-101,Inhibitor;UCPH-101, Selective EAAT1 inhibitor;2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
- CBNumber
- CB42487582
- Molecular Formula
- C27H22N2O3
- Formula Weight
- 422.48
- MOL File
- 1118460-77-7.mol
UCPH-101 Property
- Melting point:
- 194.0-197.2 °C
- Boiling point:
- 703.5±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in DMSO (up to 10 mg/ml).
- form
- solid
- pka
- 3.23±0.60(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21460
- Product name
- UCPH-101
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 21460
- Product name
- UCPH-101
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 21460
- Product name
- UCPH-101
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 3490
- Product name
- UCPH101
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $901
- Updated
- 2021/12/16
- Product number
- 3490
- Product name
- UCPH101
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $215
- Updated
- 2021/12/16
UCPH-101 Chemical Properties,Usage,Production
Description
UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system. UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 μM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier.
Uses
UCPH 101 is a subtype-selective inhibitor of human excitatory amino acid transporter subtype 1.
IC 50
EAAT1
storage
Store at +4°C
References
[1] ANDERS A. JENSEN*. Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1[J]. Journal of Medicinal Chemistry, 2009, 52 4: 912-915. DOI:10.1021/jm8013458
[2] METTE N. ERICHSEN. Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)[J]. Journal of Medicinal Chemistry, 2010, 53 19: 7180-7191. DOI:10.1021/jm1009154
[3] CRISTINA CORBETTA. Altered function of the glutamate–aspartate transporter GLAST, a potential therapeutic target in glioblastoma[J]. International Journal of Cancer, 2018, 144 10: 2539-2554. DOI:10.1002/ijc.31985
UCPH-101 Preparation Products And Raw materials
Raw materials
Preparation Products
UCPH-101 Suppliers
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View Lastest Price from UCPH-101 manufacturers
- Product
- UCPH-101 1118460-77-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24