ChemicalBook > CAS DataBase List > UCPH-101

UCPH-101

Product Name
UCPH-101
CAS No.
1118460-77-7
Chemical Name
UCPH-101
Synonyms
CS-2757;UCPH-101;UCPH-101; UCPH 101; UCPH101;inhibit,UCPH101,UCPH-101,Inhibitor;2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
CBNumber
CB42487582
Molecular Formula
C27H22N2O3
Formula Weight
422.48
MOL File
1118460-77-7.mol
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UCPH-101 Property

Melting point:
194.0-197.2 °C
Boiling point:
703.5±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
form 
solid
pka
3.23±0.60(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21460
Product name
UCPH-101
Purity
≥98%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
21460
Product name
UCPH-101
Purity
≥98%
Packaging
1mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
21460
Product name
UCPH-101
Purity
≥98%
Packaging
5mg
Price
$477
Updated
2024/03/01
Tocris
Product number
3490
Product name
UCPH101
Purity
≥98%(HPLC)
Packaging
50
Price
$901
Updated
2021/12/16
Tocris
Product number
3490
Product name
UCPH101
Purity
≥98%(HPLC)
Packaging
10
Price
$215
Updated
2021/12/16
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UCPH-101 Chemical Properties,Usage,Production

Description

UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system. UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 μM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier.

Uses

UCPH 101 is a subtype-selective inhibitor of human excitatory amino acid transporter subtype 1.

storage

Store at +4°C

References

1) Jensen?et al.?(2009),?Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1; J. Med. Chem.,?52?912 2) Erichsen?et al.?(2010),?Structure-Activity Relationship Study of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101); J. Med. Chem.,?53?7180 3) Corbetta?et al.?(2019),?Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma; Int. J. Cancer,?144?2539

UCPH-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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UCPH-101 Suppliers

China 38 India 1 United Kingdom 2 United States 7 Global 48
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66099280 17798518460
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(1)02557626880
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cfzhang@aikonchem.com
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China
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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020-39119999
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isunpharm@qq.com
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd
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17754423994 17754423994
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2853530910@QQ.com
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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21-5161 9052
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info@SuperLan-chem.com
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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Medi-tech Bioscientific Co., Ltd.
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0519-83246372 13585352506
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Twochem Co.Ltd.
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Angel Pharmatech, Ltd.
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Guangzhou Tomums Life Science Co., Ltd.
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sales@tomums.cn
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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18081075745
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chemflowtech@sina.com
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DC Chemicals
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021-58447131 13564518121
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career henan chemical co
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factory@coreychem.com
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SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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Energy Chemical
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MedBioPharmaceutical Technology Inc
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order@med-bio.cn
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Hefei Mokai Pharmaceutical Technology Co., Ltd
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18130062233
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Shanghai Universal Biotech Co.,Ltd
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ChemeGen 中国
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Bide Pharmatech Ltd.
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InvivoChem
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TargetMol Chemicals Inc.
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Beijing InnoChem Science & Technology Co., Ltd.
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Henan Alpha Chemical Co., Ltd.
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Beijing Solarbio Science & Tecnology Co., Ltd.
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View Lastest Price from UCPH-101 manufacturers

Career Henan Chemical Co
Product
UCPH-101 1118460-77-7
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

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  • UCPH-101
  • 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
  • 4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
  • 2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
  • UCPH-101; UCPH 101; UCPH101
  • CS-2757
  • 2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
  • inhibit,UCPH101,UCPH-101,Inhibitor
  • 1118460-77-7
  • Glutamate