ChemicalBook > CAS DataBase List > UCPH-101

UCPH-101

Product Name
UCPH-101
CAS No.
1118460-77-7
Chemical Name
UCPH-101
Synonyms
CS-2757;UCPH-101;UCPH-101 ，S0297;UCPH-101, 10 mM in DMSO;UCPH-101; UCPH 101; UCPH101;inhibit,UCPH101,UCPH-101,Inhibitor;UCPH-101, Selective EAAT1 inhibitor;2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CBNumber
CB42487582
Molecular Formula
C27H22N2O3
Formula Weight
422.48
MOL File
1118460-77-7.mol
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UCPH-101 Property

Melting point:
194.0-197.2 °C
Boiling point:
703.5±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
form 
solid
pka
3.23±0.60(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21460
Product name
UCPH-101
Purity
≥98%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
21460
Product name
UCPH-101
Purity
≥98%
Packaging
1mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
21460
Product name
UCPH-101
Purity
≥98%
Packaging
5mg
Price
$477
Updated
2024/03/01
Tocris
Product number
3490
Product name
UCPH101
Purity
≥98%(HPLC)
Packaging
10
Price
$215
Updated
2021/12/16
Tocris
Product number
3490
Product name
UCPH101
Purity
≥98%(HPLC)
Packaging
50
Price
$901
Updated
2021/12/16
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UCPH-101 Chemical Properties,Usage,Production

Description

UCPH-101 is a noncompetitive inhibitor of excitatory amino acid transporter 1 (EAAT1), which takes up extracellular glutamate in the central nervous system. UCPH-1 is selective for EAAT1 over EAAT2 and EAAT3 with IC50 values of 0.66, >300, and >300 μM, respectively, in a radioligand uptake assay using HEK293 cells transfected with the human transporter. It selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. UCPH-101 is orally bioavailable in rats at a dose of 10 mg/kg but does not cross the blood-brain barrier.

Uses

UCPH 101 is a subtype-selective inhibitor of human excitatory amino acid transporter subtype 1.

IC 50

EAAT1

storage

Store at +4°C

References

[1] ANDERS A. JENSEN*. Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1[J]. Journal of Medicinal Chemistry, 2009, 52 4: 912-915. DOI:10.1021/jm8013458
[2] METTE N. ERICHSEN. Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)[J]. Journal of Medicinal Chemistry, 2010, 53 19: 7180-7191. DOI:10.1021/jm1009154
[3] CRISTINA CORBETTA. Altered function of the glutamate–aspartate transporter GLAST, a potential therapeutic target in glioblastoma[J]. International Journal of Cancer, 2018, 144 10: 2539-2554. DOI:10.1002/ijc.31985

UCPH-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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UCPH-101 Suppliers

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View Lastest Price from UCPH-101 manufacturers

Career Henan Chemical Co
Product
UCPH-101 1118460-77-7
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

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  • UCPH-101
  • 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
  • 4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
  • 2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
  • UCPH-101; UCPH 101; UCPH101
  • CS-2757
  • 2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
  • inhibit,UCPH101,UCPH-101,Inhibitor
  • UCPH-101, Selective EAAT1 inhibitor
  • UCPH-101, 10 mM in DMSO
  • UCPH-101 ，S0297
  • 1118460-77-7
  • Glutamate