S-NITROSOGLUTATHIONE Property

Melting point:

>170°C (dec.)

Density 

1.68

refractive index 

1.6000 (estimate)

storage temp. 

-20°C

solubility 

DMSO (Slightly), Water (Slightly)

form 

Pink solid

pka

2.21±0.10(Predicted)

color 

Off-White to Pink

Water Solubility 

Soluble to 100 mM in water

Stability:

Hygroscopic

CAS DataBase Reference

57564-91-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

MC0558000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

S-NITROSOGLUTATHIONE Chemical Properties,Usage,Production

Description

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.

Chemical Properties

Pink Powder

Uses

A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation

Uses

S-Nitrosoglutathione (GSNO) has been used:

• as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
• as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.

Definition

ChEBI: S-nitrosoglutathione is a glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. It has a role as a platelet aggregation inhibitor, a bronchodilator agent, a nitric oxide donor and a signalling molecule. It is a glutathione derivative and a nitrosothio compound. It is a conjugate acid of a S-nitrosoglutathione(2-).

General Description

A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

Biological Activity

A carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation.

Biochem/physiol Actions

Product does not compete with ATP.

storage

Desiccate at -20°C