Drug for treatment of Genital warts Clinical Study Mechanism of action Usage and Dosage Side effects Precautions Uses
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Imiquimod

Drug for treatment of Genital warts Clinical Study Mechanism of action Usage and Dosage Side effects Precautions Uses
Product Name
Imiquimod
CAS No.
99011-02-6
Chemical Name
Imiquimod
Synonyms
ALDARA;R-837;TMX101;S-26308;TMX 101;TMX-101;Zyclara;imiqimod;imiquimo;Miquimod
CBNumber
CB2664655
Molecular Formula
C14H16N4
Formula Weight
240.3
MOL File
99011-02-6.mol
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Imiquimod Property

Melting point:
292-294°C
Boiling point:
456.7±48.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble
pka
6.28±0.30(Predicted)
form 
White solid
color 
White
Water Solubility 
Soluble in dimethyl sulfoxide and dimethyl formamide. Slightly soluble in water. Insoluble in ethanol.
λmax
245nm(H2O/MeOH)(lit.)
Merck 
14,4922
Stability:
Incompatible with strong oxidizing agents.
InChIKey
DOUYETYNHWVLEO-UHFFFAOYSA-N
CAS DataBase Reference
99011-02-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
26-45-36/37/39-27
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
NJ5903450
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
Hazardous Substances Data
99011-02-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2716
Product name
Imiquimod
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 500?mg
Packaging
500MG
Price
$241
Updated
2024/03/01
Sigma-Aldrich
Product number
401020
Product name
Imiquimod
Packaging
250mg
Price
$370
Updated
2024/03/01
Sigma-Aldrich
Product number
1338313
Product name
Imiquimod
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
I0747
Product name
Imiquimod
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$67
Updated
2024/03/01
TCI Chemical
Product number
I0747
Product name
Imiquimod
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$330
Updated
2024/03/01
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Imiquimod Chemical Properties,Usage,Production

Drug for treatment of Genital warts

Imiquimod is a kind of imidozoquinoline amine-class interleukin agonist developed by the 3M Pharmaceuticals Company (US), belonging to the drug for the treatment of genital warts. Upon being applied to the mice skin, it can induce the cytokinesis and produce α-interferon, tumor necrosis factor and many kinds of interleukins. Clinically it can be used as the immunomodulators in the treatment of adult genital and perianal warts with convenient application, well tolerance and unique mechanism of action which makes it be the first-choice drug for treatment of genital warts. In addition, there are reports that imiquimod can be used for treating viral skin diseases including common warts, flat warts, molluscum and herpes simplex virus. It can also be effective in treating basal cell carcinoma, Bowen's disease, Bowen papulosis, actinic keratosis, and skin tumors such as cutaneous T-cell tumor and Kaposi's sarcoma. It may also be effective in treating vitiligo and alopecia areata.
Genital wart is the infective diseases of the human herpes virus (HPV) infection and is a major public health threat. Currently, the infection of the genital wart in the United States is the most common viral infective sexually transmitted diseases and one of the most common sexually transmitted diseases. The infections mostly occur in sexually active people, especially for people of 20 to 24 year-olds and women in pregnancy, and prone to happen at the warm and most mucosal sites of body. Application of immunosuppressive agents or infection with the patients of human immunodeficiency virus is prone to cause severe clinical signs of infection.

Clinical Study

In an unpublished report, 209 cases of patients of genital or perianal warts have been subjected to a double-blind trial with both this product and vehicles being used for three times per week for continuous 16 weeks. The results have shown that, 33 cases in 46 cases of women (72%), 21 cases in 63 cases of male(33%) get cured with the total wart cure rate being 50%, while only 11% (20% of women and 5% male) in the vehicles group get cured. There have been patients who get cured within treatment of only 4 weeks. The average healing time is twelve weeks for men and eight weeks for women. In the following 12 weeks, there were 39 cases in 54 cases that got no recurrence any more.

Mechanism of action

Imiquimod itself has no direct effect on the virus itself, but instead through stimulating the body for producing cytokines and stimulating immune response to eliminate the wart tissue and reduce the viral erosion.
Both in vivo and in vitro studies have suggested that imiquimod can stimulate the mice, rats, rabbits, guinea pigs, monkeys and humans for producing cytokine. Racial cross cell culture tests have shown that the main responsive cells are monocytes/macrophages; cultured human peripheral mononuclear cells (PBMC) which can produce several subtypes of IFN-α, TNF-α, IL-1,6,6 , 10,12, MIP-1 and MCP-1; the human single cell THP-1 will respond only when being pre-subject to γ-IFN treatment and produce TNF-α, IL-1,6,8, but do not produce IFN-α; performing the same treatment on the fresh mice PBMC can generate the same cytokine as human PBMC; senescence macrophages and alveolar macrophages produce the same cytokines, the mouse RAW264.7 and J774 macrophages family can produce TNF-α and IL-6 without producing IFN-α. Through intracellular test, we can confirm that imiquimod can induce IFN-α and TNF-α.
Through putting the human fibroblasts and keratinocytes with the mixture of imiquimod or poly-inosine: poly-cytidine for incubation of 24 hours, people has found that the mRNA of keratinocytes IL-6 and IL-8 (no TNF-α) had increased but only appropriate amount of IL-8 protein had been detected. At high concentration, the secretion of the fibroblasts IL-8 is similar with keratinocytes; The immune response of caused by the imiquimod-induced secretion of cytokines is similar with the DTH response; imiquimod can activate the anti-tumor activity and DTH response of the HPV E7 gene transfected tumor bearing mice; human and animal experiments have shown that imiquimod could increase the 2'5'-oligo-adenylate synthase which can induce the interferon for inducing the antiviral effect; interferons and other cytokines can activate NK cells to kill tumor cells and the virus-infected cells; both in vivo and in vitro tests have showed that the imiquimod can increase activity of NK and stimulate the proliferation and activation of mouse spleen B cells which is the direct effect rather than being mediated by cytokine; imiquimod does not directly enhance T-lymphocyte activity; but in vitro mitogenic response can stimulate T-cells for enhancing the production and proliferation of IL-2. In vivo experiments have demonstrated that it can enhance T cell activity; imiquimod can increase the generation of IL-2 of the HSV infected guinea pig, T cell proliferation and T cell activity to enhance the cell-mediated immune response.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Usage and Dosage

It can be used for the treatment of adult external genital and perianal genital warts at 3 times per week. Just before sleep, first apply the product evenly in a thin layer on the surface of the wart and gently massage until the product is completely absorbed. The position of the medication should not be packeted and should be maintained for 6 to 10 hours, and then wash with a neutral soap and clean water for clearing the drugs in the administration site. Wash your hands before and after treatment. 250 mg of cream can be applied to 20cm2 of wart. Avoid excessive application of the drug. Patients should continue the treatment until the wart is completely cleared. Wart can be cleared within 2-4 week at the fastest speed and can be generally cleared within 8 to 12 weeks. The medication should be not more than 16 weeks. After the treatment, patients with mild erythema locally who does not have to be discontinued for drug; if the patients feel general malaise or get local skin reactions (edema, erosion, pain, etc.), the drug should be discontinued. Only when the reaction is alleviated can they continue the medication.

Side effects

1, the majority of patients get no adverse reactions during the treatment. After several times of treatment, the clinical adverse reactions are mostly mild, moderate local skin inflammation. For example, there may be local skin erythema, edema, erosion, ulcers, desquamation, burning, pain, itching and so on.
2, there is occasional transient fever and these symptoms can quickly recover after stopping the drugs. If the reactions are mild, you can continue for the treatment. However, the patients should discontinue the drug on time and should be subject to medical treatment if severe reactions happen.
3, According to the reports of foreign information, possible adverse reactions associated with imiquimod cream include discomfort in the medication site, wart site reactions (burning, pigmentation, inflammation, itching, pain, rash, sensitivity, ulcers, tingling and tenderness).Distal site reactions (bleeding, burning, itching, pain and tenderness), fatigue, fever, flu-like symptoms, headache, diarrhea, myalgia.

Precautions

1. No packets; wash away the drug after 6 to 10 hours of the drug administration. The patients should avoid using this product in partial breakage place. There have been reports of using drugs or laser for treatment of genital warts that lead to the emergence of damaged parts. In that case, we should continue the drugs until the wound get healed.
2. It should not be applied to the treatment of genital warts located at the eyes, mouth, nose, urethra, vagina, cervix and anal mucous membranes.
3. You should avoid sex during the treatment. For patients using condom, the patients should first clean the topical imiquimod because imiquimod can make condom be fragile.
4. For male patients with foreskin, during the treatment, the patients should reveal the foreskin every day and clean the application site. If the foreskin mucosa surface gets erosion, ulceration, edema and difficulty for turning up foreskin, you should immediately stop the treatment.
5. There have been no reports regarding the drug contraindications in pregnant and lactating women, but the patients should use with caution.

Uses

It can be used for anti-genital warts and as immunomodulators

Description

Aldara was launched in the US for the topical treatment of genital warts caused by human papillomavirus (HPV). It can be prepared in a six step approach beginning with the nucleophilic substitution of 4-chloro-3-nitroquinolone with isobutylamine or via a thermal electrocyclic ring closure of 1 - and 2-azahexatriene systems. Aldara has antiviral and antitumor properties, with the former activity arising from the induction of cytokines, in particular, INF-α. Aldara also induces TNF-γ, IL-1α, IL-1β, IL-1ra, IL-6, IL-8, IL-10, GM-CSF, G-CSF and MID-la formation 1-4 hr after stimuli. The exact cells responsible for the response have not been determined, however, it is not activating T lymphocytes, NK cells, B lymphocytes, or dendritic stem cells but monocytes (CD14+, CD36+, HLA-DR+, HLA-DQ±, CD19-, CD16- and CD23-) are partly responsible. The speculation is that Aldara may interact with a kinase modulating the transduction pathway leading to cytokine genes. There is no direct antiviral activity (induction of IFN does not follow true dose response) and it is not mutagenic. The hydroxylated metabolite also induces IFN-α.

Chemical Properties

White to off white crystalline powder

Originator

3M Pharmaceuticals (US)

Uses

An immune response modifier. It stimulates the production of interferon-a

Uses

Imiquimod is a caspase 3 activator which acts as an immunomodulator and displays antiviral and anti-tumor activity. It is a patient-applied cream used for the treatment of genital warts and basal cell carcinoma. It is also used to cure actinic keratosis on the face and scalp. It belongs to a group of drugs called immune response modifiers, which work by activating the immune system to fight abnormal skin growth.

Uses

raw material for Latamoxef, Cefminox, Ceftizoxime, Cefoxitin, Cefmetazole

Definition

ChEBI: Imiquimod is an imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis. It has a role as an antineoplastic agent and an interferon inducer.

Indications

Imiquimod (Aldara) is a topical immune response modifier approved for the treatment of anogenital warts (condylomata acuminata). The exact mechanism of action is unknown; it has no direct antiviral activity in vitro. It is thought to work in vivo by inducing the production of tumor necrosis factor (TNF α ), interferons (IFN)α and γ , and other cytokines with antiviral activity. It may also be useful for treatment of other types of warts, molluscum contagiosum, and certain forms of skin cancer. Local irritant reactions related to the frequency of application are common.

brand name

Aldara (3M Pharmaceuticals).

Pharmaceutical Applications

An imidazoquinoline used for the treatment of genital and perianal warts. While the mechanism of action is not precisely known, it is thought to induce interferon. It has no direct antiviral activity. The 5% cream applied three times a week for up to 16 weeks resulted in total wart clearance in 50% of patients, with a better response in women than in men. Local reactions are common and include erythema, erosion, excoriation and edema.

Biological Activity

Immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR-7) agonist; stimulates proinflammatory cytokine production and activates NF- κ B.

Biochem/physiol Actions

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.

Mechanism of action

Imiquimod (Aldara) is an imidazoquinolone amine that is an immune responsemodifier. Its exact mechanism is unknown in the topical treatment of HPV and molluscum contagiosum but may be related to the immunomodulating effect of the drug. It is also effective in the treatment of actinic keratoses and superficial basal cell carcinoma.
It induces production of a variety of cytokines and can enhance cell-mediated cytolytic antiviral activity. It is a rapid and potent inducer of interferon-α, interleukin?1 α and β, interleukin 6, interleukin 8, tumor necrosis factor-α, granulocyte-macrophage colony-stimulating factor, and granulocyte colonystimulating factor. Systemic absorption is minimal. It is generally well tolerated. Adverse local reactions include erythema, erosion, excoriation, flaking, and edema of the treatment sites.

Veterinary Drugs and Treatments

An immune response modifier, imiquimod may be useful in the treatment of a variety of topical conditions in animals. It is labeled for use on humans as a treatment for genital or perianal warts, superficial basal cell carcinomas and actinic keratoses of the face and scalp. In dogs and cats, imiquimod potentially may be of benefit in treating feline herpes virus dermatitis, actinic keratosis, squamous cell carcinoma and Bowen’s disease, papillomas virus lesions, and localized solar dermatitis or solar carcinoma in situ. In horses, imiquimod has been anecdotally used with success in treating sarcoids.
Imiquimod stimulates the patient’s own immune system to release a variety of cytokines including interferon-alpha and interleukin- 12. Imiquimod itself does not have in vitro activity against wart viruses, but stimulates monocytes and macrophages to release cytokines that induce a regression in viral protein production.

storage

+4°C

References

1) Hemmi?et al.?(2002),?Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway;?Nat. Immunol.?3?196 2) Stanley?et al.?(2002),?Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential;?Clin. Exp. Dermatol.?27?571 3) Schoen?et al.?(2006),?The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion;?J.Invest.Dermatol.?126?1338 4) Kan?et al.?(2012),?Imiquimod Suppresses Propagation of Herpes Simplex Virus 1 by Upregulation of Cystatin A via the Adenosine Receptor A1?Pathway.; J. Virol.?86?10338 5) Urosevic?et al.?(2004),?Imiquimod Treatment Induces Expression of Opioid Growth Factor Receptor; Clin. Cancer Res.?10?4959 6) Zagon?et al.?(2008),?Imiquimod Upregulates the Opioid Growth Factor Receptor to Inhibit Cell Proliferation Independent of Immune Function.; Exp. Biol. Med.(Maywood)?233?968

Imiquimod Preparation Products And Raw materials

Raw materials

4-Hydroxyquinoline

Preparation Products

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Imiquimod Suppliers

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021-61984905-1 18016477331
Email
synchempharma@aliyun.com
Country
China
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Wuhan Bo-Sen Biological Technology Co., Ltd
Tel
027-51335350 15107175693
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027-51335350
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bosenyuan@foxmail.com
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View Lastest Price from Imiquimod manufacturers

Hebei Dangtong Import and export Co LTD
Product
Imiquimod 99011-02-6
Price
US $6.00-3.00/grams
Min. Order
100grams
Purity
99%
Supply Ability
100tons
Release date
2023-02-14
Hebei Dangtong Import and export Co LTD
Product
Imiquimod 99011-02-6
Price
US $1107.00-900.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
8000kg
Release date
2023-09-15
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
imiquimod 99011-02-6
Price
US $15.00/kg
Min. Order
1kg
Purity
99.912%
Supply Ability
10ton
Release date
2024-04-23

99011-02-6, ImiquimodRelated Search:

Bis(2-ethylhexyl)amine Glycine Ethoxyquin 1,2,3,4-TETRAHYDROISOQUINOLINE Quinhydrone ALTRENOGEST Betaine Isoquinoline Lithium diisopropylamide Quinclorac Aniline 4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE Imiquimod Related Compound B (25 mg) (1-Isobutyl-1H-imidazo[4,5-c]quinoline 5-oxide) Imiquimod Related Compound D (25 mg) (1-Propyl-1H-imidazo[4,5-c]quinolin-4-amine) [99010-09-0], C13H17N3,215.30 4-amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinolin-1-ethanol Imiquimod Impurity 2

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