2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE

Product Name: 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
CAS No.: 222978-02-1
Chemical Name: 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
Synonyms: 4-Cyano-3-fluorobenzyl alcohol;2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE;Benzonitrile, 2-fluoro-4-(hydroxymethyl)-;Benzonitrile, 2-fluoro-4-(hydroxymethyl)- (9CI)
CBNumber: CB2684833
Molecular Formula: C8H6FNO
Formula Weight: 151.14
MOL File: 222978-02-1.mol

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2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Property

Melting point:: 66-68
storage temp.: Sealed in dry,Room Temperature
Appearance: Light yellow to yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F598068
Product name: 2-Fluoro-4-(hydroxymethyl)benzonitrile
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 046734
Product name: 2-Fluoro-4-(hydroxymethyl)benzenecarbonitrile
Purity: >90%
Packaging: 500mg
Price: $38
Updated: 2021/12/16

Matrix Scientific

Product number: 046734
Product name: 2-Fluoro-4-(hydroxymethyl)benzenecarbonitrile
Purity: >90%
Packaging: 1g
Price: $59
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-3-X7
Product name: 2-Fluoro-4-(hydroxymethyl)benzonitrile
Packaging: 1g
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011639
Product name: 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
Purity: 95.00%
Packaging: 1G
Price: $212.1
Updated: 2021/12/16

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2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Chemical Properties,Usage,Production

Synthesis

433939-83-4

222978-02-1

To a mixed solution of CH2Cl2 and 5 mL of methanol containing 2-fluoro-4-vinylbenzonitrile (1.3 g, 8.8 mmol), which was cooled to 40°C at -78°C, ozone (at a concentration of 29 g/m3) was drummed at a flow rate of 50 L/h for 30 minutes. Subsequently, argon was passed to remove unreacted ozone. After addition of sodium borohydride (0.67 g, 0.018 mol), the cooling bath was removed and the reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed by evaporation and 2M HCl solution was added. The mixture was extracted twice with ether and the combined organic phases were dried with anhydrous Na2SO4 followed by evaporation of the solvent. The crude product was purified by crystallization to afford the target product 2-fluoro-4-(hydroxymethyl)benzonitrile 1.1 g in 81% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.59 (m, 1H), 7.3-7.2 (m, 2H), 4.79 (d, 2H), 2.26 (t, 1H).

References

[1] Patent: US2004/19033, 2004, A1. Location in patent: Page/Page column 45
[2] Patent: WO2003/101956, 2003, A1. Location in patent: Page 127

2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Suppliers

China 54 Europe 1 India 1 United Kingdom 1 United States 12 Global 69

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View Lastest Price from 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE manufacturers

Career Henan Chemical Co

Product: 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE 222978-02-1
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

222978-02-1, 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILERelated Search:

3-Fluorobenzyl alcohol Benzonitrile 4-(HYDROXYMETHYL)BENZONITRILE 3-Fluoro-4-(hydroxymethyl)benzonitrile 4-Fluoro-2-(hydroxymethyl)benzonitrile 4-cyano-2,3,5,6-tetrafluorobenzoic acid ethyl 4-cyano-3-fluorobenzenecarboxylate Benzonitrile, 2-fluoro-4-(1-hydroxyethyl)- (9CI) Methyl 4-cyano-3-fluorobenzoate 4-Cyano-3-fluorobenzoic acid 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE

2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE

4-Cyano-3-fluorobenzyl alcohol

Benzonitrile, 2-fluoro-4-(hydroxymethyl)- (9CI)

Benzonitrile, 2-fluoro-4-(hydroxymethyl)-

222978-02-1

HALIDE

ALDEHYDE