ChemicalBook > CAS DataBase List > 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE

2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE

Product Name
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
CAS No.
222978-02-1
Chemical Name
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
Synonyms
4-Cyano-3-fluorobenzyl alcohol;2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE;Benzonitrile, 2-fluoro-4-(hydroxymethyl)-;Benzonitrile, 2-fluoro-4-(hydroxymethyl)- (9CI)
CBNumber
CB2684833
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
222978-02-1.mol
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2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Property

Melting point:
66-68
storage temp. 
Sealed in dry,Room Temperature
Appearance
Light yellow to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F598068
Product name
2-Fluoro-4-(hydroxymethyl)benzonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
046734
Product name
2-Fluoro-4-(hydroxymethyl)benzenecarbonitrile
Purity
>90%
Packaging
500mg
Price
$38
Updated
2021/12/16
Matrix Scientific
Product number
046734
Product name
2-Fluoro-4-(hydroxymethyl)benzenecarbonitrile
Purity
>90%
Packaging
1g
Price
$59
Updated
2021/12/16
SynQuest Laboratories
Product number
4637-3-X7
Product name
2-Fluoro-4-(hydroxymethyl)benzonitrile
Packaging
1g
Price
$200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011639
Product name
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
Purity
95.00%
Packaging
1G
Price
$212.1
Updated
2021/12/16
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2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Chemical Properties,Usage,Production

Synthesis

433939-83-4

222978-02-1

To a mixed solution of CH2Cl2 and 5 mL of methanol containing 2-fluoro-4-vinylbenzonitrile (1.3 g, 8.8 mmol), which was cooled to 40°C at -78°C, ozone (at a concentration of 29 g/m3) was drummed at a flow rate of 50 L/h for 30 minutes. Subsequently, argon was passed to remove unreacted ozone. After addition of sodium borohydride (0.67 g, 0.018 mol), the cooling bath was removed and the reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed by evaporation and 2M HCl solution was added. The mixture was extracted twice with ether and the combined organic phases were dried with anhydrous Na2SO4 followed by evaporation of the solvent. The crude product was purified by crystallization to afford the target product 2-fluoro-4-(hydroxymethyl)benzonitrile 1.1 g in 81% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.59 (m, 1H), 7.3-7.2 (m, 2H), 4.79 (d, 2H), 2.26 (t, 1H).

References

[1] Patent: US2004/19033, 2004, A1. Location in patent: Page/Page column 45
[2] Patent: WO2003/101956, 2003, A1. Location in patent: Page 127

2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE manufacturers

Career Henan Chemical Co
Product
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE 222978-02-1
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

222978-02-1, 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILERelated Search:

3-Fluorobenzyl alcohol Benzonitrile 4-(HYDROXYMETHYL)BENZONITRILE 3-Fluoro-4-(hydroxymethyl)benzonitrile 4-Fluoro-2-(hydroxymethyl)benzonitrile 4-cyano-2,3,5,6-tetrafluorobenzoic acid ethyl 4-cyano-3-fluorobenzenecarboxylate Benzonitrile, 2-fluoro-4-(1-hydroxyethyl)- (9CI) Methyl 4-cyano-3-fluorobenzoate 4-Cyano-3-fluorobenzoic acid 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE

  • 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
  • 4-Cyano-3-fluorobenzyl alcohol
  • Benzonitrile, 2-fluoro-4-(hydroxymethyl)- (9CI)
  • Benzonitrile, 2-fluoro-4-(hydroxymethyl)-
  • 222978-02-1
  • HALIDE
  • ALDEHYDE