2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
- Product Name
- 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
- CAS No.
- 222978-02-1
- Chemical Name
- 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
- Synonyms
- 4-Cyano-3-fluorobenzyl alcohol;2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE;Benzonitrile, 2-fluoro-4-(hydroxymethyl)-;Benzonitrile, 2-fluoro-4-(hydroxymethyl)- (9CI)
- CBNumber
- CB2684833
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 222978-02-1.mol
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Property
- Melting point:
- 66-68
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F598068
- Product name
- 2-Fluoro-4-(hydroxymethyl)benzonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 046734
- Product name
- 2-Fluoro-4-(hydroxymethyl)benzenecarbonitrile
- Purity
- >90%
- Packaging
- 500mg
- Price
- $38
- Updated
- 2021/12/16
- Product number
- 046734
- Product name
- 2-Fluoro-4-(hydroxymethyl)benzenecarbonitrile
- Purity
- >90%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 4637-3-X7
- Product name
- 2-Fluoro-4-(hydroxymethyl)benzonitrile
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- HCH0011639
- Product name
- 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $212.1
- Updated
- 2021/12/16
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Chemical Properties,Usage,Production
Synthesis
433939-83-4
222978-02-1
To a mixed solution of CH2Cl2 and 5 mL of methanol containing 2-fluoro-4-vinylbenzonitrile (1.3 g, 8.8 mmol), which was cooled to 40°C at -78°C, ozone (at a concentration of 29 g/m3) was drummed at a flow rate of 50 L/h for 30 minutes. Subsequently, argon was passed to remove unreacted ozone. After addition of sodium borohydride (0.67 g, 0.018 mol), the cooling bath was removed and the reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed by evaporation and 2M HCl solution was added. The mixture was extracted twice with ether and the combined organic phases were dried with anhydrous Na2SO4 followed by evaporation of the solvent. The crude product was purified by crystallization to afford the target product 2-fluoro-4-(hydroxymethyl)benzonitrile 1.1 g in 81% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.59 (m, 1H), 7.3-7.2 (m, 2H), 4.79 (d, 2H), 2.26 (t, 1H).
References
[1] Patent: US2004/19033, 2004, A1. Location in patent: Page/Page column 45
[2] Patent: WO2003/101956, 2003, A1. Location in patent: Page 127
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE Suppliers
- Tel
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- sales@ajchem.in
- Country
- India
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View Lastest Price from 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE manufacturers
- Product
- 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE 222978-02-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02