Description References
ChemicalBook > CAS DataBase List > Adefovir

Adefovir

Description References
Product Name
Adefovir
CAS No.
106941-25-7
Chemical Name
Adefovir
Synonyms
PMEA;GS-393;gs0393;Adefovi;ADEFOVIR;A Duff Vee;Adefovir98%;Adefovir API;adefovir ,97%;Adefovir(PMEA)
CBNumber
CB2698137
Molecular Formula
C8H12N5O4P
Formula Weight
273.19
MOL File
106941-25-7.mol
More
Less

Adefovir Property

Melting point:
>260°C
Boiling point:
632.5±65.0 °C(Predicted)
Density 
1.88
storage temp. 
-20°C
solubility 
0.1 M NaOH: ≥5mg/mL
form 
powder
pka
pKa1 2.0, pKa2 6.8(at 25℃)
color 
white to beige
InChIKey
SUPKOOSCJHTBAH-UHFFFAOYSA-N
CAS DataBase Reference
106941-25-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
2811
WGK Germany 
3
RTECS 
SZ6563500
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
29339900
Hazardous Substances Data
106941-25-7(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0240
Product name
Adefovir
Purity
≥98% (HPLC)
Packaging
10mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0240
Product name
Adefovir
Purity
≥98% (HPLC)
Packaging
50mg
Price
$441
Updated
2024/03/01
Cayman Chemical
Product number
18650
Product name
Adefovir
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18650
Product name
Adefovir
Purity
≥95%
Packaging
50mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18650
Product name
Adefovir
Purity
≥95%
Packaging
100mg
Price
$243
Updated
2024/03/01
More
Less

Adefovir Chemical Properties,Usage,Production

Description

Adefovir (Trade name: Preveon, Hepsera) is a prescription drug used for the treatment of chronic infections of hepatitis B virus. It can be formulated as the pivoxil prodrug adefovir dipivoxil. However, it shows no effect against HIV-1. As a orally administrated acyclic nucleotide analog reverse transcriptase inhibitor, it blocking the reproduction of HBV through inhibiting the reverse transcriptase in the body. One of its advantages over another anti-HBV drug, lamivudine is that it is much harder for the virus to develop resistance to it.

References

https://www.drugbank.ca/drugs/DB00718
http://en.wikipedia.org/wiki/Adefovir

Chemical Properties

Pale Brown Solid

Uses

Used as an antiviral

Uses

Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.

Definition

ChEBI: Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir(1-).

Acquired resistance

It has a lower propensity to induce drug resistance than lamivudine. Clinical trials of patients receiving 48 weeks of therapy did not identify any cases of resistance. Longer courses yield resistant strains of HBV with mutations in the DNA polymerase gene; other rare variants of resistant strains have been identified. Lamivudine-resistant strains of HBV retain susceptibility to adefovir.

Pharmaceutical Applications

A nucleotide analog of adenosine monophosphate, administered orally as its prodrug, adefovir dipivoxil.

Biochem/physiol Actions

Adefovir is an antiviral drug that after intracellular conversion to adefovir diphosphate inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase).

Pharmacokinetics

Oral absorption： c. 60%
Cmax 10 mg/kg oral： 18.4 ng/mL
Plasma half-life： c. 7.5 h.
Volume of distribution： 392 mL/kg
Plasma protein binding： Not known
The prodrug is metabolized to adefovir, which is excreted by the kidneys and therefore requires dose adjustment in patients with impaired renal function. It does not induce cytochrome P450 at standard doses and does not influence the metabolism or plasma concentrations of the other licensed medications used in the treatment of hepatitis B.

Clinical Use

Treatment of chronic hepatitis B virus infection in patients >12 years of age

Side effects

It is generally well tolerated, with headache, pharyngitis, abdominal pain and peripheral neuropathy being the most common side effects. Nephrotoxicity has been observed in some patients, with those receiving higher doses and longer courses of therapy at greater risk. Exacerbation of hepatitis has been reported in patients immediately following discontinuation of treatment. Most exacerbations occur within 12 weeks of stopping therapy, and elevations of alanine aminotransferase (ALT) up to 10 times the upper limit of normal can be observed in over 25% of patients. Lactic acidosis has been reported in a few patients and is an indication for immediate discontinuation.

Adefovir Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Adefovir Suppliers

Canada 1 China 335 Europe 2 France 1 Germany 1 India 9 South Korea 1 United Kingdom 10 United States 42 USA 1 Global 403
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
RR Scientific LLC
Tel
+86-13917743231
Email
sales@rrscientific.com
Country
United States
ProdList
878
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
SynFine Research
Tel
--
Fax
--
Email
research@synfine.com
Country
United States
ProdList
1024
Advantage
68
CacheSyn Inc.
Tel
--
Fax
--
Email
info@cachesyn.com
Country
United States
ProdList
695
Advantage
50
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
Olinax Inc.
Tel
--
Fax
--
Email
info@olinax.com
Country
United States
ProdList
404
Advantage
50
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Advanced Molecular Technologies
Tel
--
Fax
--
Email
enquiries@amtechpl.com
Country
United States
ProdList
136
Advantage
38
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Moravek Biochemicals, Inc.
Tel
--
Fax
--
Email
moravek@worldnet.att.net
Country
United States
ProdList
1227
Advantage
69
QVENTAS INC.
Tel
--
Fax
--
Email
mike@qventas.com
Country
United States
ProdList
383
Advantage
47
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
More
Less

View Lastest Price from Adefovir manufacturers

Sinoway Industrial co., ltd.
Product
Adefovir 106941-25-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-09-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Adefovir 106941-25-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
500kgs
Release date
2021-09-16
Hebei Weibang Biotechnology Co., Ltd
Product
Adefovir 106941-25-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

106941-25-7, AdefovirRelated Search:

m-Anisyl alcohol Glycine Methoxydiethylborane Anisole Adenine ALTRENOGEST (Trifluoromethoxy)benzene Methoxyacetic acid Tris(hydroxymethyl)aminomethane p-Anisidine 6-Aminocaproic acid Gemcitabine hydrochloride Adefovir Dipivoxil Impurity 20 [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid diethyl ester Adefovir iMpurity Adefovir Dipivoxil Impurity 4 ((hydroxy((2-(6-pivalaMido-9H-purin-9-yl)ethoxy)Methyl)phosphoryl)oxy)Methyl pivalate 9-vinyl-9H-purin-6-amine

  • treatment Adefovir
  • Tenofovir Desmethyl Impurity
  • 2-(6-amino-9h-purin-
  • Adefovir dipivox (PMEA)
  • [[2-(6-AMino-9H-purin-9-yl)ethoxy] Methyl]phosponic Acid
  • P-[[2-(6-AMino-9H-purin-9-yl)ethoxy]Methyl]phosphonic Acid
  • Adefovir(PMEA)
  • Adefovir98%
  • [({[2-(6-aMino-9H-purin-9-yl)ethoxy]Methyl}({[(2,2-diMethylpropanoyl)oxy]Methoxy})phosphoryl)oxy]Methyl 2,2-diMethylpropanoate
  • A Duff Vee
  • Adefovir API
  • GS-393
  • P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine
  • 2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonic acid Adefovir(PMEA)
  • Adefovir Dipivoxil Impurity (Adefovir)
  • 2-(6-amino-9h-purin-9-yl)ethoxy]methylphosphonic acid
  • 9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE
  • 9-(2-PHOSPHONYL METHOXY ETHYL) ADENINE
  • ADEFOVIR
  • PMEA
  • ((2-(6-amino-9h-purin-9-yl)ethoxy)methyl)-phosphonicaci
  • 9-[2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonicacid
  • [[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphonic acid (PMEA)
  • PMEA([[2-(6-amino-9H-purin-9-yl)
  • Adefovi
  • 9-[2- (phosphonomethoxy) ethyl] adenine, alternate name adefovir[PMEA]
  • [2-(6-Amino-9H-purine-9-yl)ethoxymethyl]phosphonic acid
  • Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- (9CI)
  • 9-[2-(6-Amino-9H-purin-9-yl)et
  • Adefovir & Adefovir Dipivoxil
  • gs0393
  • adefovir ,97%
  • 9-[2-[bis(pivaloyloxymethoxy)phosphorylmethoxyl]ethyl]adenine
  • 9-(2-Phosphonomethoxy Etheyl) Adenine
  • 9-(2-PHOSPHORYL METHOXYL ETHYL) ADENINE
  • 9-(2-(2-phosphoromethoxy)ethyl adenine (PMEA)
  • Adefovir dipivoxil intermediate B
  • 2-(6-AMINO-9H-OUR IN-9-YL)ETHOXY]METHYLPHOSPHONIC ACID
  • 9-[2-phosphonylmethoxyethyl]ad
  • Adefovir,9-[2-phosphonylmethoxyethyl]adenine
  • 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE(ADEFOVIR)
  • [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosponicAcid,PMEA,GS-393,
  • Phosphonic acid, P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
  • Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
  • Adefovir USP/EP/BP
  • Adefovir (GS-0393)
  • AdefovirQ: What is Adefovir Q: What is the CAS Number of Adefovir Q: What is the storage condition of Adefovir Q: What are the applications of Adefovir
  • 3-Di-o-tolylguanidine
  • 2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid
  • 106941-25-7
  • C8H12N5O4P
  • C8H13N5O4P
  • C8H14N5O4P
  • Other Products
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals