2,3-Pyrazinedicarboxylic acid Property

Melting point:

188 °C (dec.) (lit.)

Boiling point:

297.01°C (rough estimate)

Density 

1.6328 (rough estimate)

refractive index 

1.4738 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble

pka

1.66±0.10(Predicted)

form 

Solid

color 

Off-White to Pale Brown

Water Solubility 

soluble

Merck 

14,7958

BRN 

147982

InChIKey

ZUCRGHABDDWQPY-UHFFFAOYSA-N

LogP

-1.257 (est)

CAS DataBase Reference

89-01-0(CAS DataBase Reference)

Safety

Hazard Codes 

F,C

Risk Statements 

36/37/38-34-11

Safety Statements 

22-24/25-45-36/37/39-26-16

WGK Germany 

3

RTECS 

UQ2500000

TSCA 

N

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

2,3-Pyrazinedicarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to pale brown crystalline powder

Uses

2,3-Pyrazinedicarboxylic Acid has been found to exhibit antifungal and antibacterial acitivity. It has also been used as a reagent in the preparation of transition metal pyrazinedicarboxylate complexes.

Description

2,3-Pyrazinedicarboxylic acid is an antibacterial compound, and its anions have been of great interest in coordination and supra-molecular chemistry as they generally tend to react with metal salts to yield insoluble polynuclear materials. Its anion has been shown to have critical applications in crystal engineering because of the crystal formation of 2,3-Pyrazinedicarboxylic acid with creatinine and 2-amino-4-hydroxy-6-methylpyrimidine. 2,3-Pyrazinedicarboxylic acid (pzdc) is a dicarboxylate ligand. This compound could bridge two neighboring metal atoms to form a 1D chain in complexes. The pzdc ligands also could coordinate with the central Nd(III) atoms in bridging tetradentate, hexadentate, or heptadentate modes. 2,3-pyrazinedicarboxylic acid (pzdc) and neodymium nitrate could synthesize the coordination polymer [Nd2(pzdc)3(H2O)]n·nH2O (complex I) with a three-dimensional framework through hydrothermal synthesis[1-4].

Purification Methods

Crystallise the dicarboxylic acid from water and dry it at 100o. The dimethyl ester has m 62-63o (from Et2O or Et2O/pet ether). [Beilstein 25 H 168, 25 II 164, 25 III/IV 1064.]

References

[1] Faizan, Mohd , et al. "Structural, vibrational and electronic absorption characteristics of the monohydrate organic salt of 2-amino-5-bromo-6-methyl-4-pyrimidinol and 2,3-pyrazinedicarboxylic acid: A combined experimental and computational study." Journal of Molecular Structure 1177(2019):229-241.
[2] Beaula, T Joselin , et al. "Quantum chemical computations, vibrational spectroscopic analysis and antimicrobial studies of 2,3-Pyrazinedicarboxylic acid." Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 138C(2014):723-735.
[3] Yin, Hua , and S. X. Liu . "Copper and zinc complexes with 2,3-pyridinedicarboxylic acid or 2,3-pyrazinedicarboxylic acid: Polymer structures and magnetic properties." Journal of Molecular Structure 918.1-3(2009):165-173.
[4] Yang, Li Rong , et al. "Synthesis, structure and luminescent properties of neodymium(III) coordination polymers with 2,3-pyrazinedicarboxylic acid." Synthetic Metals 161. 9–10(2011):647-654.