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Fluvoxamine maleate

Product Name
Fluvoxamine maleate
CAS No.
61718-82-9
Chemical Name
Fluvoxamine maleate
Synonyms
Fluvoxamine for system suitability CRS;Luvox;MK-264;du23000;Dumirox;Faverin;Fevarin;Maveral;faverin50;Floxyfral
CBNumber
CB2722966
Molecular Formula
C19H25F3N2O6
Formula Weight
434.41
MOL File
61718-82-9.mol
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Fluvoxamine maleate Property

Melting point:
120-121.5 °C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
color 
White to Off-White
Water Solubility 
Soluble in water (10mM)
Merck 
14,4219
BCS Class
1
InChIKey
LFMYNZPAVPMEGP-PIDGMYBPSA-N
SMILES
C(C1C=CC(=CC=1)/C(=N\OCCN)/CCCCOC)(F)(F)F.C(O)(=O)/C=C\C(O)=O
CAS DataBase Reference
61718-82-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-36/37/39-27-26
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
SA9230000
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F-040
Product name
Fluvoxamine maleate
Purity
1.0?mg/mL in methanol (as free base), certified reference material, Cerilliant?
Packaging
1mL
Price
$92.8
Updated
2024/03/01
Sigma-Aldrich
Product number
BP671
Product name
Fluvoxamine maleate impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
BP600
Product name
Fluvoxamine maleate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
1285909
Product name
Fluvoxamine maleate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$1200
Updated
2024/03/01
TCI Chemical
Product number
F0858
Product name
Fluvoxamine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$115
Updated
2024/03/01
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Fluvoxamine maleate Chemical Properties,Usage,Production

Description

Fluvoxamine maleate is the most recent of the serotonin-specific antidepressants to reach the market. In vitro and in vivo animal experiments have shown fluvoxamine to have a marked effect on 5-HT mediated processes and little effect on norepinephrine. Clinical trials suggest similar efficacy to imipramine and clomipramine with a somewhat lower incidence of side effects, especially anticholinergic effects. Fluvoxamine, in contrast to the tricyclic antidepressants, does not appear to produce heart rate increase, postural hypotension or prolongation of the intraventricular conduction time and QT interval.

Chemical Properties

Crystalline Solid

Originator

Duphar (Netherlands)

Uses

A selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.

Uses

estrogen

Uses

nonsteroidal anti-inflammatory reduces pain and inflammation in eyes

Uses

Anxiety disorder

Uses

Fluvoxamine maleate has been used as a test compound to determine the solubility and effective blood-brain barrier permeability.(2)

Definition

ChEBI: Fluvoxamine maleate is a member of (trifluoromethyl)benzenes.

Manufacturing Process

20.4 mmol (5.3 g) of 5-methoxy-4'-trifluoromethylvalerophenone (MP 43°C to 44°C), 20.5 mmol (3.1 g) of 2-aminooxyethylamine dihydrochloride and 10 ml of pyridine were refluxed for 15 hr in 20 ml of absolute ethanol. After evaporating the pyridine and the ethanol in vacuo, the residue was dissolved in water. This solution was washed with petroleum ether and 10 ml of 50% sodium hydroxide solution were then added. Then three extractions with 40 ml of ether were carried out. The ether extract was washed successively with 20 ml of 5% sodium bicarbonate solution and 20 ml of water. After drying on sodium sulfate, the ether layer was evaporated in vacuo. Toluene was then evaporated another three times (to remove the pyridine) and the oil thus obtained was dissolved in 15 ml of absolute ethanol. An equimolar quantity of maleic acid was added to the solution and the solution was then heated until a clear solution was obtained. The ethanol was then removed in vacuo and the residue was crystallized from 10 ml of acetonitrile at +5°C. After sucking off and washing with cold acetonitrile, it was dried in air. The MP of the resulting compound was 120°C to 121.5°C.

brand name

Luvox (Solvay Pharmaceuticals);FLOXYFRAL.

Therapeutic Function

Antidepressant

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Hazard

A poison by ingestion. Human systemic effects.

Biological Activity

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a K i of 1.6 nmol/l. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .

Biochem/physiol Actions

Fluvoxamine maleate is a selective neuronal serotonin reuptake inhibitor. It functions as an antidepressant and anti-obsessive agent. It is useful in treating obsessive compulsive disorder and panic disorder.

Clinical Use

SSRI antidepressant:
Depression
Obsessive compulsive disorder

Veterinary Drugs and Treatments

Fluvoxamine may be considered for use in treating a variety of behavior- related diagnoses in dogs and cats, including aggression and stereotypic behaviors (and other obsessive-compulsive behaviors).

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: increased aminophylline and theophylline concentrations - avoid; if not possible, halve aminophylline or theophylline dose and monitor levels.
Analgesics: increased risk of bleeding with aspirin and NSAIDs; risk of CNS toxicity increased with tramadol; concentration of methadone possibly increased.
Anti-arrhythmics: increased risk of toxicity with mexiletine.
Anticoagulants: effect of coumarins possibly enhanced; possibly increased risk of bleeding with dabigatran.
Antidepressants: avoid with reboxetine, MAOIs, moclobemide and St John’s wort; possibly enhanced serotonergic effects with mirtazapine; fluvoxamine inhibits metabolism of duloxetine - avoid; can increase tricyclics concentration; metabolism of agomelatine reduced; possible increased risk of convulsions with vortioxetine.
Antiepileptics: antagonise anticonvulsant threshold; concentration of carbamazepine, fosphenytoin and phenytoin increased.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: concentration of asenapine, haloperidol, clozapine and olanzapine increased; increased risk of ventricular arrhythmias with droperidol and possibly pimozide - avoid.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: may increase ciclosporin concentration.
Clopidogrel: possibly reduced antiplatelet effect.
Cytotoxics: concentration of pomalidomide increased
Dapoxetine: possible increased risk of serotonergic effects - avoid.
Dopaminergics: increased risk of CNS toxicity with rasagiline - avoid; hypertension and CNS excitation with selegiline - avoid.
5HT1 agonists: risk of CNS toxicity increased with sumatriptan; possibly increased risk of serotonergic effects with naratriptan; inhibits metabolism of frovatriptan; possibly inhibits metabolism of zolmitriptan - reduce zolmitriptan dose.
Linezolid: use with care, possibly increased risk of side effects.
Lithium: increased risk of CNS effects - monitor levels.
Melatonin: concentration of melatonin increased - avoid.
Methylthioninium: risk of CNS toxicity - avoid if possible.
Muscle relaxants: increased risk of toxicity with tizanidine - avoid
Pirfenidone: concentration of pirfenidone increased - avoid.

Metabolism

Fluvoxamine undergoes extensive hepatic transformation by CYP2D6, mainly via oxidative demethylation, into at least 9 metabolites. The 2 major metabolites showed negligible pharmacological activity. The other metabolites are not expected to be pharmacologically active.
Excretion is mainly in the urine; about 2% of a dose is excreted as unchanged drug.

storage

+4°C (desiccate)

Fluvoxamine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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Fluvoxamine maleate Suppliers

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View Lastest Price from Fluvoxamine maleate manufacturers

Zibo Wei Bin Import & Export Trade Co. Ltd.
Product
Fluvoxamine maleate 61718-82-9
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1t
Release date
2023-07-11
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Fluvoxamine maleate 61718-82-9
Price
US $55.00-550.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-20
Hong Kong Excellence Biotechnology Co., Ltd.
Product
Fluvoxamine maleate 61718-82-9
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12

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  • 61718-82-9
  • 61718-82-8
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  • C15H21F3N2O2C4H4O
  • C19H25F3N2O6
  • C14H18F3N2O2C4H4O4
  • ESTROVIS
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Serotonin receptor
  • 61718-82-9