ChemicalBook > CAS DataBase List > Fluvoxamine maleate

Fluvoxamine maleate

Product Name
Fluvoxamine maleate
CAS No.
61718-82-9
Chemical Name
Fluvoxamine maleate
Synonyms
Fluvoxamine for system suitability CRS;Luvox;MK-264;du23000;Dumirox;Faverin;Fevarin;Maveral;faverin50;Floxyfral
CBNumber
CB2722966
Molecular Formula
C19H25F3N2O6
Formula Weight
434.41
MOL File
61718-82-9.mol
More
Less

Fluvoxamine maleate Property

Melting point:
120-121.5 °C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
color 
White to Off-White
Water Solubility 
Soluble in water (10mM)
Merck 
14,4219
BCS Class
1
InChIKey
LFMYNZPAVPMEGP-PIDGMYBPSA-N
SMILES
C(C1C=CC(=CC=1)/C(=N\OCCN)/CCCCOC)(F)(F)F.C(O)(=O)/C=C\C(O)=O
CAS DataBase Reference
61718-82-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-36/37/39-27-26
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
SA9230000
HS Code 
29280000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F-040
Product name
Fluvoxamine maleate
Purity
1.0?mg/mL in methanol (as free base), certified reference material, Cerilliant?
Packaging
1mL
Price
$92.8
Updated
2024/03/01
Sigma-Aldrich
Product number
BP671
Product name
Fluvoxamine maleate impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
BP600
Product name
Fluvoxamine maleate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
1285909
Product name
Fluvoxamine maleate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$1200
Updated
2024/03/01
TCI Chemical
Product number
F0858
Product name
Fluvoxamine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$115
Updated
2024/03/01
More
Less

Fluvoxamine maleate Chemical Properties,Usage,Production

Description

Fluvoxamine maleate is the most recent of the serotonin-specific antidepressants to reach the market. In vitro and in vivo animal experiments have shown fluvoxamine to have a marked effect on 5-HT mediated processes and little effect on norepinephrine. Clinical trials suggest similar efficacy to imipramine and clomipramine with a somewhat lower incidence of side effects, especially anticholinergic effects. Fluvoxamine, in contrast to the tricyclic antidepressants, does not appear to produce heart rate increase, postural hypotension or prolongation of the intraventricular conduction time and QT interval.

Chemical Properties

Crystalline Solid

Originator

Duphar (Netherlands)

Uses

A selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.

Uses

estrogen

Uses

nonsteroidal anti-inflammatory reduces pain and inflammation in eyes

Uses

Anxiety disorder

Uses

Fluvoxamine maleate has been used as a test compound to determine the solubility and effective blood-brain barrier permeability.(2)

Definition

ChEBI: Fluvoxamine maleate is a member of (trifluoromethyl)benzenes.

Manufacturing Process

20.4 mmol (5.3 g) of 5-methoxy-4'-trifluoromethylvalerophenone (MP 43°C to 44°C), 20.5 mmol (3.1 g) of 2-aminooxyethylamine dihydrochloride and 10 ml of pyridine were refluxed for 15 hr in 20 ml of absolute ethanol. After evaporating the pyridine and the ethanol in vacuo, the residue was dissolved in water. This solution was washed with petroleum ether and 10 ml of 50% sodium hydroxide solution were then added. Then three extractions with 40 ml of ether were carried out. The ether extract was washed successively with 20 ml of 5% sodium bicarbonate solution and 20 ml of water. After drying on sodium sulfate, the ether layer was evaporated in vacuo. Toluene was then evaporated another three times (to remove the pyridine) and the oil thus obtained was dissolved in 15 ml of absolute ethanol. An equimolar quantity of maleic acid was added to the solution and the solution was then heated until a clear solution was obtained. The ethanol was then removed in vacuo and the residue was crystallized from 10 ml of acetonitrile at +5°C. After sucking off and washing with cold acetonitrile, it was dried in air. The MP of the resulting compound was 120°C to 121.5°C.

brand name

Luvox (Solvay Pharmaceuticals);FLOXYFRAL.

Therapeutic Function

Antidepressant

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Hazard

A poison by ingestion. Human systemic effects.

Biological Activity

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a K i of 1.6 nmol/l. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .

Biochem/physiol Actions

Fluvoxamine maleate is a selective neuronal serotonin reuptake inhibitor. It functions as an antidepressant and anti-obsessive agent. It is useful in treating obsessive compulsive disorder and panic disorder.

Clinical Use

SSRI antidepressant:
Depression
Obsessive compulsive disorder

Veterinary Drugs and Treatments

Fluvoxamine may be considered for use in treating a variety of behavior- related diagnoses in dogs and cats, including aggression and stereotypic behaviors (and other obsessive-compulsive behaviors).

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: increased aminophylline and theophylline concentrations - avoid; if not possible, halve aminophylline or theophylline dose and monitor levels.
Analgesics: increased risk of bleeding with aspirin and NSAIDs; risk of CNS toxicity increased with tramadol; concentration of methadone possibly increased.
Anti-arrhythmics: increased risk of toxicity with mexiletine.
Anticoagulants: effect of coumarins possibly enhanced; possibly increased risk of bleeding with dabigatran.
Antidepressants: avoid with reboxetine, MAOIs, moclobemide and St John’s wort; possibly enhanced serotonergic effects with mirtazapine; fluvoxamine inhibits metabolism of duloxetine - avoid; can increase tricyclics concentration; metabolism of agomelatine reduced; possible increased risk of convulsions with vortioxetine.
Antiepileptics: antagonise anticonvulsant threshold; concentration of carbamazepine, fosphenytoin and phenytoin increased.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: concentration of asenapine, haloperidol, clozapine and olanzapine increased; increased risk of ventricular arrhythmias with droperidol and possibly pimozide - avoid.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: may increase ciclosporin concentration.
Clopidogrel: possibly reduced antiplatelet effect.
Cytotoxics: concentration of pomalidomide increased
Dapoxetine: possible increased risk of serotonergic effects - avoid.
Dopaminergics: increased risk of CNS toxicity with rasagiline - avoid; hypertension and CNS excitation with selegiline - avoid.
5HT1 agonists: risk of CNS toxicity increased with sumatriptan; possibly increased risk of serotonergic effects with naratriptan; inhibits metabolism of frovatriptan; possibly inhibits metabolism of zolmitriptan - reduce zolmitriptan dose.
Linezolid: use with care, possibly increased risk of side effects.
Lithium: increased risk of CNS effects - monitor levels.
Melatonin: concentration of melatonin increased - avoid.
Methylthioninium: risk of CNS toxicity - avoid if possible.
Muscle relaxants: increased risk of toxicity with tizanidine - avoid
Pirfenidone: concentration of pirfenidone increased - avoid.

Metabolism

Fluvoxamine undergoes extensive hepatic transformation by CYP2D6, mainly via oxidative demethylation, into at least 9 metabolites. The 2 major metabolites showed negligible pharmacological activity. The other metabolites are not expected to be pharmacologically active.
Excretion is mainly in the urine; about 2% of a dose is excreted as unchanged drug.

storage

+4°C (desiccate)

Fluvoxamine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Fluvoxamine maleate Suppliers

Americas 1 Belgium 2 Canada 5 China 276 Colombia 1 Czech Republic 1 Europe 3 France 3 Germany 6 India 67 Iran 1 Israel 1 Japan 5 Poland 1 South Korea 1 Spain 2 Switzerland 4 The Netherlands 1 United Arab Emirates 1 United Kingdom 15 United States 38 Global 435
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
Advantage
60
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Jigs Chemical Limited
Tel
--
Fax
--
Email
info@jigschemical.com
Country
India
ProdList
235
Advantage
58
Aril Pharmaceuticals (Aril Biosciences Pvt. Ltd.)
Tel
--
Fax
--
Email
marketing@arilpharmaceuticals.com
Country
India
ProdList
67
Advantage
58
Sun Pharmaceutical Industries Ltd.
Tel
--
Fax
--
Email
SunPharma.IndiaBusiness@sunpharma.com
Country
India
ProdList
99
Advantage
58
Globofarm International Private Limited
Tel
--
Fax
--
Email
procurement@globofarm.net
Country
India
ProdList
188
Advantage
58
Mesha Pharma Private Limited
Tel
--
Fax
--
Country
India
ProdList
133
Advantage
58
Dharmanandan Export Pvt., Ltd.
Tel
--
Fax
--
Email
info@dnexport.com
Country
India
ProdList
161
Advantage
58
Innorex Pharmaceuticals Private Limited
Tel
--
Fax
--
Email
info@innorexpharma.com
Country
India
ProdList
173
Advantage
58
Gemini Exports
Tel
--
Fax
--
Email
uiry@geminiexpor
Country
India
ProdList
140
Advantage
58
B. Shah & Sons
Tel
--
Fax
--
Country
India
ProdList
79
Advantage
58
Anika International Pvt. Limited
Tel
--
Fax
--
Email
info@anika.in
Country
India
ProdList
94
Advantage
58
RL FINE CHEM PVT LTD
Tel
--
Fax
--
Email
enquiry@rlfinechem.com
Country
India
ProdList
49
Advantage
58
Unnati Pharmaceuticals Pvt. Ltd.
Tel
--
Fax
--
Email
unnatipharma@gmail.com
Country
India
ProdList
86
Advantage
58
Srini Pharmaceuticals Limited
Tel
--
Fax
--
Country
India
ProdList
11
Advantage
58
Orient Pharma
Tel
--
Fax
--
Email
info@orientpharma.in
Country
India
ProdList
204
Advantage
58
Merit International
Tel
--
Fax
--
Email
meritasia2@gmail.com
Country
India
ProdList
226
Advantage
58
Euro-India Chems Pvt., Ltd.
Tel
--
Fax
--
Email
euroindiachems@gmail.com
Country
India
ProdList
31
Advantage
58
Premier Drug House
Tel
--
Fax
--
Email
premierdrughouse@gmail.com
Country
India
ProdList
66
Advantage
58
Athos Chemicals
Tel
--
Fax
--
Email
export@athoschemicals.com
Country
India
ProdList
315
Advantage
58
Humble Healthcaare Limited
Tel
--
Fax
--
Email
export@humblehealthcaare.com
Country
India
ProdList
63
Advantage
58
Ralington Pharma.
Tel
--
Fax
--
Email
info@ralingtonpharma.com
Country
India
ProdList
311
Advantage
58
Mehta Pharmaceutical Industries
Tel
--
Fax
--
Email
atul@mehtapharma.com
Country
India
ProdList
15
Advantage
58
Mehta API Pvt., Ltd.
Tel
--
Fax
--
Email
info@mehtaapi.com
Country
India
ProdList
14
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
RA CHEM PHARMA LTD
Tel
--
Fax
--
Email
info@rachempharma.com
Country
India
ProdList
37
Advantage
58
Luconic Chemicals
Tel
--
Fax
--
Country
India
ProdList
72
Advantage
58
Maas Pharma Chemicals
Tel
--
Fax
--
Email
info@maaspharmachemicals.com
Country
India
ProdList
1607
Advantage
58
SRINI PHARMACEUTICALS PRIVATE LTD
Tel
--
Fax
--
Email
info@srinipharma.com
Country
India
ProdList
36
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Innovative Synthetic Molecules
Tel
--
Fax
--
Country
India
ProdList
526
Advantage
58
Dazzle Corporation
Tel
--
Fax
--
Email
enquiry@dazzlecorporation.co.in
Country
India
ProdList
209
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
Novas International
Tel
--
Fax
--
Email
info@novasinternational.com
Country
India
ProdList
210
Advantage
58
Ayon PharmaChem
Tel
--
Fax
--
Email
bhargav@ayonpharmachem.com
Country
India
ProdList
303
Advantage
58
ZCL CHEMICALS LTD
Tel
--
Fax
--
Email
enquiries@zclchemicals.com
Country
India
ProdList
31
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Swapnroop Drugs & Pharmaceuticals
Tel
--
Fax
--
Email
sales@swapnroopdrugs.com
Country
India
ProdList
91
Advantage
50
Jai Radhe Sales
Tel
--
Fax
--
Email
nikunj@jairadhesales.com
Country
India
ProdList
157
Advantage
57
Biopharmacule Speciality Chemicals P Ltd (India)
Tel
--
Fax
--
Country
India
ProdList
526
Advantage
58
Primarius Custom Synthesis P. Ltd.
Tel
--
Fax
--
Email
info@primariusfinechem.com
Country
India
ProdList
43
Advantage
0
Indogulf Group
Tel
--
Fax
--
Email
info@indogulfgroup.com
Country
India
ProdList
249
Advantage
58
Siddhivinayak Chemicals
Tel
--
Fax
--
Email
info@siddhivinayakchemicals.com
Country
India
ProdList
13
Advantage
58
Triveni Interchem Private Limited (Group Of Triveni...
Tel
--
Fax
--
Country
India
ProdList
497
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
ZCL CHEMICALS LTD.
Tel
--
Fax
--
Email
enquiries@zclchemicals.com
Country
India
ProdList
9
Advantage
58
SUN PHARMACEUTICAL INDUSTRIES LTD
Tel
--
Fax
--
Email
secretarial@sunpharma.com
Country
India
ProdList
175
Advantage
58
More
Less

View Lastest Price from Fluvoxamine maleate manufacturers

Sinoway Industrial co., ltd.
Product
Fluvoxamine Maleate 61718-82-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-06-25
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Fluvoxamine Maleate 61718-82-9
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-19
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Fluvoxamine maleate 61718-82-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-04

61718-82-9, Fluvoxamine maleateRelated Search:

Trimebutine maleate (Trifluoromethoxy)benzene 4-Methoxybenzylchloride 4-Methoxyphenylacetone 3-Methoxybenzaldehyde Enalapril maleate p-Anisaldehyde Anisole Bis(2-ethylhexyl) maleate Chlorphenamine maleate 4-Methoxyphenylacetic acid Disodium fumarate Fluvoxamine Maleic acid PHENYL VALERATE p-Anisidine Phenylacetic acid 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone

  • FLUVOXAMINE MALEATE
  • (E)-5-METHOXY-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-PENTANONE-O-(2-AMINOETHYL)OXIME MALEATE
  • 1-pentanone,5-methoxy-1-(4-(trifluoromethyl)phenyl)-,o-(2-aminoethyl)oxime,(
  • 5-methoxy-4’-trifluoromethylvalerophenone(e)-o-2-aminoethyloximemonomaleate
  • du23000
  • faverin50
  • (E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-O-(2-aminoethyl)oxime-1-pentanone
  • Fluvoxamine maleate,(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate
  • Fluvoxamine Maleate (200 mg)
  • (E)-5-Methoxy-1-(4-(trifluoroMethyl)phenyl)pentan-1-one O-(2-aMinoethyl) oxiMe Maleate
  • (E)-5-Methoxy-1-[4-(trifluoroMethyl)]-1-pentanone-O-(2-aMinoehyl)oxiMe Maleate
  • 2-[[5-Methoxy-1-[4-(trifluoromethyl)phenyl]-pentylidene]amino]oxyethanamine maleate
  • MK-264, DI-23000, Dumirox, Flaverrin, Fevarin, Floxyfral, Luvox, Maveral, (E)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone, Maleate,
  • (E)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-2-aminoethyl oxime
  • 1-Pentanone, 5-methoxy-1-4-(trifluoromethyl)phenyl-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1)
  • Fluvoxamine Maleat
  • (E)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate
  • Dumirox
  • Faverin
  • Fevarin
  • Floxyfral
  • Luvox
  • Maveral
  • MK-264
  • (E)-Fluvoxamine Maleate
  • Fluvoxamine maleate, 98%, a selective serotonin (5-HT) reuptake inhibitor (SSRI)
  • FluvoxaMine Meleate
  • 1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate
  • FluvoxamineMaleate&gt
  • Fluvoxamine Maleate RS
  • Fluvoxamine maleate CRS
  • Fluvoxamine for system suitability CRS
  • DU-23000 (maleate)
  • Fluvoxamine maleate USP/EP/BP
  • Fluvoxamine maleate (DU23000 maleate)
  • Fluvoxamine D4 MaleateQ: What is Fluvoxamine D4 Maleate Q: What is the CAS Number of Fluvoxamine D4 Maleate Q: What is the storage condition of Fluvoxamine D4 Maleate Q: What are the applications of Fluvoxamine D4 Maleate
  • Fluvoxamine maleateQ: What is Fluvoxamine maleate Q: What is the CAS Number of Fluvoxamine maleate Q: What is the storage condition of Fluvoxamine maleate Q: What are the applications of Fluvoxamine maleate
  • "Fluvoxamine Maleate 13C, D3"
  • Fluvoxamine Maleate (1285909)
  • FLUVOXAMINE MALEATE IP/BP/USP
  • Fluvoxamine (DU-23000) maleate
  • Fluvoxamine maleate in methanol
  • 61718-82-9
  • 61718-82-8
  • 61717-82-9
  • C15H21F3N2O2C4H4O
  • C19H25F3N2O6
  • C14H18F3N2O2C4H4O4
  • ESTROVIS
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Serotonin receptor
  • 61718-82-9