Nortropinone hydrochloride
- Product Name
- Nortropinone hydrochloride
- CAS No.
- 25602-68-0
- Chemical Name
- Nortropinone hydrochloride
- Synonyms
- NORTROPINONE HCL;8-Azabicyclo[3.2.1]octan-3-one hydrochloride;Ntp·HCl;Tropicanol;ABLOCK AB-10-5429;Nortropinone HCl ,98%;Nortropinone HydrochL;NORTROPINONE HYDROCHLORIDE;Nortropanone Hydrochloride;Nortropinone hydroehloride
- CBNumber
- CB2724566
- Molecular Formula
- C7H12ClNO
- Formula Weight
- 161.63
- MOL File
- 25602-68-0.mol
Nortropinone hydrochloride Property
- Melting point:
- >180°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Dichloromethane, Methanol
- form
- Solid
- color
- White to yellow-brown
- Sensitive
- Hygroscopic
- InChI
- InChI=1/C7H11NO.ClH/c9-7-3-5-1-2-6(4-7)8-5;/h5-6,8H,1-4H2;1H/t5-,6+;
- InChIKey
- MZQWQFWRSDNBPV-KNCHESJLNA-N
- SMILES
- [C@]12([H])CC[C@]([H])(CC(=O)C1)N2.Cl |&1:0,4,r|
- CAS DataBase Reference
- 25602-68-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PHL84089
- Product name
- Nortropinone hydrochloride
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 50 mg
- Price
- $208
- Updated
- 2025/07/31
- Product number
- CDS021991
- Product name
- Nortropinone hydrochloride
- Packaging
- 100mg
- Price
- $42.8
- Updated
- 2025/07/31
- Product number
- N0844
- Product name
- Nortropinone Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- N0844
- Product name
- Nortropinone Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $343
- Updated
- 2025/07/31
- Product number
- 285390
- Product name
- Nortropinone hydrochloride
- Packaging
- 500mg
- Price
- $425
- Updated
- 2021/12/16
Nortropinone hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
Nortropinone hydrochloride is a metabolite of Tropinone. It is also used as an inhibitor in reactions that involve 11 beta-hydroxysteroid dehydrogenase type 1 enzyme. It plays an important role in the process of drug discovery, as it is an excellent linker component or building block and is useful in exploring a vast range of therapeutics and drugs.
Synthesis
532-24-1
25602-68-0
1. 8-Methyl-8-azabicyclo[3.2.1]octan-3-one (tropinone, 10.0 g, 71.84 mmol) was dissolved in dichloroethane (DCE, 60 mL), and 1-chloroethyl chloroformate (ACE-C1, 14.5 mL, 19.11 g, 133.7 mmol) was slowly added dropwise. The reaction mixture was stirred at room temperature overnight and subsequently diluted with ether (Et2O, 400 mL) and filtered. The filtrate was concentrated under reduced pressure to give crude chloroethyl carbamate. 2. The above crude product was dissolved in methanol (MeOH, 200 mL) and stirred at room temperature for 1 h. Subsequently, it was concentrated under reduced pressure at 55 °C to obtain crude desmethyltropinone hydrochloride (brown solid, 11.4 g, 98% yield). 3. The crude product was recrystallized by acetonitrile to afford purified demethyltophenone hydrochloride (white crystalline solid, 5 g, 43% yield). 4. Demethyltophenone (5.10 g, 31.55 mmol) was dissolved in dichloromethane (CH2Cl2, 50 mL) and benzyl chloroformate (4.29 mL, 5.11 g, 29.98 mmol) and diisopropylethylamine (DIPEA, 16.48 mL, 12.23 g, 94.66 mmol) were added slowly and dropwise (note exothermic reaction). The reaction mixture was stirred at room temperature for 30 min and subsequently diluted with dichloromethane (100 mL). The organic phase was washed with 1N hydrochloric acid (2 x 100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product (7.2 g, 88% yield).
References
[1] Patent: WO2006/23852, 2006, A2. Location in patent: Page/Page column 84
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1817 - 1820
[3] Patent: WO2010/126163, 2010, A1. Location in patent: Page/Page column 38
[4] Patent: WO2007/100670, 2007, A1. Location in patent: Page/Page column 47
Nortropinone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Nortropinone hydrochloride Suppliers
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- Country
- India
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- Country
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View Lastest Price from Nortropinone hydrochloride manufacturers
- Product
- Nortropinone hydrochloride 25602-68-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-10-22
- Product
- Nortropinone HCl 25602-68-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-10-07
- Product
- Nortropinone HCl 25602-68-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2 t
- Release date
- 2023-11-01