2,3-Pyridinedicarboxylic acid dimethyl ester

Product Name: 2,3-Pyridinedicarboxylic acid dimethyl ester
CAS No.: 605-38-9
Chemical Name: 2,3-Pyridinedicarboxylic acid dimethyl ester
Synonyms: DIMETHYL PYRIDINE-2,3-DICARBOXYLATE;DIMETHYL 2,3-PYRIDINEDICARBOXYLATE;NSC 17026;DIMETHYL QUINOLINATE;inic acid, 2,3-dimethyL;Quinolinic acid dimethyl;Dimethylpyridine dicarboxylate;QUINOLINIC ACID DIMETHYL ESTER;2-amino-5-pyrimidinecarboxamide;Dimethyl2,3-Pyridinedicarboxylate>
CBNumber: CB2726005
Molecular Formula: C9H9NO4
Formula Weight: 195.17
MOL File: 605-38-9.mol

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2,3-Pyridinedicarboxylic acid dimethyl ester Property

Melting point:: 56°C
Boiling point:: 262.3±20.0 °C(Predicted)
Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: Solid
pka: -0.83±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C9H9NO4/c1-13-8(11)6-4-3-5-10-7(6)9(12)14-2/h3-5H,1-2H3
InChIKey: YLGIBCYHQZTFQL-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=CC=C1C(OC)=O
CAS DataBase Reference: 605-38-9(CAS DataBase Reference)
NIST Chemistry Reference: 2,3-Pyridinedicarboxylic acid, dimethyl ester(605-38-9)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S288039
Product name: PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S288039
Product name: PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER
Purity: AldrichCPR
Packaging: 25MG
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: P1303
Product name: Dimethyl 2,3-Pyridinedicarboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: P1303
Product name: Dimethyl 2,3-Pyridinedicarboxylate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $136
Updated: 2025/07/31

TRC

Product number: D477770
Product name: Dimethyl 2,3-Pyridinedicarboxylate
Packaging: 1g
Price: $120
Updated: 2021/12/16

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2,3-Pyridinedicarboxylic acid dimethyl ester Chemical Properties,Usage,Production

Uses

Dimethyl 2,3-Pyridinedicarboxylate is a reagent in the preparation of diarylcyclopentenopyridines as endothelin receptor antagonists.

Synthesis

67-56-1

89-00-9

605-38-9

2,3-Pyridinedicarboxylic acid (80 g, 0.48 mol) was dissolved in methanol (400 ml) and stirred at room temperature for 30 minutes. Concentrated sulfuric acid (94.1 g, 0.96 mol) was then added slowly dropwise for about 1 hour. The reaction mixture was heated to 60°C and the reaction was stirred overnight. After completion of the reaction, methanol was removed by distillation under reduced pressure. The concentrate was slowly poured into aqueous sodium carbonate solution during which a large amount of gas was produced. The pH was adjusted to 7-8 and extracted with dichloromethane (1000 ml × 2). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give dimethyl 2,3-pyridinedicarboxylate as a pale yellow solid (89.7 g, 99% purity, 95.8% yield).

References

[1] Patent: CN105566319, 2016, A. Location in patent: Paragraph 0185; 0186; 0187; 0188
[2] Australian Journal of Chemistry, 1984, vol. 37, # 1, p. 87 - 94
[3] Patent: EP3252059, 2017, A1. Location in patent: Paragraph 0686; 0686-0688
[4] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 397 - 404
[5] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 3, p. 433 - 450

2,3-Pyridinedicarboxylic acid dimethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,3-Pyridinedicarboxylic acid dimethyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,3-Pyridinedicarboxylic acid dimethyl ester 605-38-9
Price: US $1000.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 200tons
Release date: 2025-08-13

Honest Joy Holdings Limited

Product: Dimethyl pyridine-2,3-dicarboxylate 605-38-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-02-20

Career Henan Chemical Co

Product: 2,3-Pyridinedicarboxylic acid dimethyl ester 605-38-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-25

605-38-9, 2,3-Pyridinedicarboxylic acid dimethyl esterRelated Search:

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2-amino-5-pyrimidinecarboxamide

DIMETHYL PYRIDINE-2,3-DICARBOXYLATE

DIMETHYL QUINOLINATE

DIMETHYL 2,3-PYRIDINEDICARBOXYLATE

2,3-PYRIDINEDICARBOXYLIC ACID DIMETHYL ESTER

2,3-Pyridinedicarboxylic acid dimethyl ester ,Dimethyl quinolinate

2,3-Pyridinedicarboxylic acid, 2,3-dimethyl ester

NSC 17026

Pyridinedicarboxylicaciddimethylester

methylquinolinic acid, 2,3-dimethyl ester

Quinolinic acid dimethyl

Dimethylpyridine dicarboxylate

2,3-diMethyl pyridine-2,3-dicarboxylate

Dimethyl Quinolinate 2,3-Pyridinedicarboxylic Acid Dimethyl Ester Quinolinic Acid Dimethyl Ester

PYRIDINE-2,3-DICARBOXYLIC ACID DIMETHYL ESTER

QUINOLINIC ACID DIMETHYL ESTER

Dimethyl2,3-Pyridinedicarboxylate&gt

inic acid, 2,3-dimethyL

2,3-Dimethyl 2,3-pyridinedicarboxylate

605-38-9

605-38-7

Heterocycle-Pyridine series