ChemicalBook > CAS DataBase List > Brompheniramine hydrogen maleate

Brompheniramine hydrogen maleate

Product Name
Brompheniramine hydrogen maleate
CAS No.
980-71-2
Chemical Name
Brompheniramine hydrogen maleate
Synonyms
dimegan;dimetane;dimotane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate;BROMPHENIRAMINE MALEATE
CBNumber
CB2736194
Molecular Formula
C20H23BrN2O4
Formula Weight
435.31
MOL File
980-71-2.mol
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Brompheniramine hydrogen maleate Property

Melting point:
134-135°C
Flash point:
9℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form 
Solid
color 
White to Off-White
λmax
261nm(lit.)
Merck 
14,1443
Stability:
Hygroscopic
InChIKey
SRGKFVAASLQVBO-BTJKTKAUSA-N
LogP
3.565 (est)
CAS DataBase Reference
980-71-2(CAS DataBase Reference)
EPA Substance Registry System
2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)
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Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
36-45-36/37-16-7
RIDADR 
3249
WGK Germany 
3
RTECS 
US4025000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
38220090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B-043
Product name
Brompheniramine maleate solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$50
Updated
2024/03/01
Sigma-Aldrich
Product number
1078008
Product name
(±)-Brompheniramine maleate salt
Packaging
125mg
Price
$358
Updated
2024/03/01
TCI Chemical
Product number
B5167
Product name
Brompheniramine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$91
Updated
2024/03/01
Alfa Aesar
Product number
J63922
Product name
Brompheniramine maleate
Packaging
25mg
Price
$85.65
Updated
2024/03/01
Alfa Aesar
Product number
J63922
Product name
Brompheniramine maleate
Packaging
100mg
Price
$249
Updated
2021/12/16
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Brompheniramine hydrogen maleate Chemical Properties,Usage,Production

Description

Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.

Chemical Properties

White Solid

Originator

Dimetane,Robins,US,1957

Uses

This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.

Uses

Antihistaminic;H1 Antagonist

Uses

An antihistamine and also an inhibitor of serotonin reuptake

Definition

ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.

Manufacturing Process

Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.

brand name

Dimetane (Wyeth).

Therapeutic Function

Antihistaminic

General Description

Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.

Side effects

The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.

Brompheniramine hydrogen maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Brompheniramine hydrogen maleate manufacturers

Wuhan Han Sheng New Material Technology Co.，Ltd
Product
Brompheniramine Maleate 980-71-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99.76%
Supply Ability
20tons
Release date
2023-04-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
Brompheniramine hydrogen maleate 980-71-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Brompheniramine hydrogen maleate 980-71-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

980-71-2, Brompheniramine hydrogen maleateRelated Search:

Chlorodimethylphenylsilane Chlorphenamine maleate Diethylstilbestrol Hydrogen Enalapril maleate DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Maleic acid Polybutene 2,6-Lutidine Trimebutine maleate Cinepazide maleate CIS-BUTENEDIOIC ANHYDRIDE Rosiglitazone maleate Disodium fumarate Propane HYDROGEN CYANIDE (-)-2-[METHYLAMINO]-1-PHENYLPROPANE D/L-AMPHETAMINE HYDROCHLORIDE

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  • C4H4O4C16H19BrN2
  • C20H23BrN204
  • C20H23BrN2O4
  • C16H19BrN2C4H4O4C20H23BrN2O4
  • C16H19BrN2C4H4O4
  • C16H19BrN2C4H4O4C20H
  • C16H19BrN2C4H4
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