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Ferrous fumarate

Product Name
Ferrous fumarate
CAS No.
141-01-5
Chemical Name
Ferrous fumarate
Synonyms
IRON FUMARATE;FERROUS FUMERATE;IRON(II) FUMARATE;firon;fumar;ircon;galfer;cpiron;ferrone;fumafer
CBNumber
CB2739933
Molecular Formula
C4H2FeO4
Formula Weight
169.9
MOL File
141-01-5.mol
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Ferrous fumarate Property

Melting point:
>280°C
Density 
2.435
vapor pressure 
0Pa at 25℃
storage temp. 
Refrigerator
solubility 
Slightly soluble in water, very slightly soluble in ethanol (96 per cent).
form 
solid
color 
Dark Red to Dark Brown
Water Solubility 
Soluble in water (0.14 g/100 ml at 25°C).
Merck 
14,4046
Exposure limits
ACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3
Stability:
Stability
InChIKey
PMVSDNDAUGGCCE-TYYBGVCCSA-L
LogP
0.62
CAS DataBase Reference
141-01-5(CAS DataBase Reference)
EPA Substance Registry System
2-Butenedioic acid (2E)-, iron(2+) salt (1:1) (141-01-5)
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Safety

Risk Statements 
36/37/38
Safety Statements 
22-36/37/39-24/25
WGK Germany 
2
RTECS 
LT1950000
TSCA 
Yes
HS Code 
29171900
Toxicity
LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1482
Product name
Ferrous fumarate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
F5381
Product name
Iron(II) fumarate
Purity
97%
Packaging
500g
Price
$147
Updated
2023/06/20
Alfa Aesar
Product number
B23956
Product name
Iron(II) fumarate, 94%
Packaging
250g
Price
$49.8
Updated
2024/03/01
Alfa Aesar
Product number
B23956
Product name
Iron(II) fumarate, 94%
Packaging
1000g
Price
$135
Updated
2024/03/01
TRC
Product number
I775300
Product name
Iron(II) fumarate
Packaging
5g
Price
$55
Updated
2021/12/16
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Ferrous fumarate Chemical Properties,Usage,Production

Description

Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.

Chemical Properties

Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.

Originator

Toleron,Mallinckrodt Inc.,US,1957

Uses

Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks.

Uses

Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency. Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.

Uses

Iron(II) fumarate is used as dietary Supplement, nutrient, iron source in foods and pharmaceuticals, as animal feed additive and in infant formulas.

Definition

Ferrous fumarate is a dicarboxylic acid. Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubility. It is used in treatment of iron deficiency anemia.

Manufacturing Process

Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found.

Therapeutic Function

Hematinic

General Description

Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant.

Flammability and Explosibility

Not classified

Clinical Use

Iron deficiency anaemia

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID.

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: reduced absorption of 4-quinolones and tetracyclines.
Dimercaprol: avoid concomitant use.
Mycophenolate: may significantly reduce absorption of mycophenolate.

Metabolism

Following absorption, the majority of iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin. The remainder is stored within ferritin or haemosiderin or is incorporated into myoglobin with smaller amounts occurring in haemcontaining enzymes or in plasma bound to transferrin. Only very small amounts are excreted as the body reabsorbs the iron after the haemoglobin has broken down.

References

Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.

Ferrous fumarate Preparation Products And Raw materials

Raw materials

Iron filings Disodium fumarate Fumaric acid Ferrous sulfate heptahydrate

Preparation Products

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View Lastest Price from Ferrous fumarate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Ferrous fumarate 141-01-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-05-11
Apeloa production Co.,Limited
Product
Iron(II) fumarate 141-01-5
Price
US $1.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
1000
Release date
2024-06-07
Hebei Weibang Biotechnology Co., Ltd
Product
Ferrous fumarate 141-01-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-10-25

141-01-5, Ferrous fumarateRelated Search:

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