Ethyl 2,4-dioxovalerate
- Product Name
- Ethyl 2,4-dioxovalerate
- CAS No.
- 615-79-2
- Chemical Name
- Ethyl 2,4-dioxovalerate
- Synonyms
- ETHYL 2,4-DIOXOPENTANOATE;ETHYL ACETOPYRUVATE;erate;Oxalacetone;2,4-dioxovaL;AKOS MSC-0252;Ethyl pyruvoxalate;TIMTEC-BB SBB008612;ETHYL ACETONOXALATE;Ethyl dioxovalerate
- CBNumber
- CB2746672
- Molecular Formula
- C7H10O4
- Formula Weight
- 158.15
- MOL File
- 615-79-2.mol
Ethyl 2,4-dioxovalerate Property
- Melting point:
- 16-18 °C (lit.)
- Boiling point:
- 101-103 °C/12 mmHg (lit.)
- Density
- 1.126 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.474(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- form
- Liquid
- pka
- 6.86±0.46(Predicted)
- color
- Clear yellow
- Specific Gravity
- 1.126
- Water Solubility
- Miscible with water, ether,chloroform, methanol and ethanol.
- BRN
- 607062
- Dielectric constant
- 16.1（19℃）
- InChIKey
- OYQVQWIASIXXRT-UHFFFAOYSA-N
- CAS DataBase Reference
- 615-79-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl 2,4-dioxovalerate(615-79-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 23-24/25-36-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29183000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 232564
- Product name
- Ethyl 2,4-dioxovalerate
- Purity
- 97%
- Packaging
- 25g
- Price
- $83.7
- Updated
- 2025/07/31
- Product number
- 232564
- Product name
- Ethyl 2,4-dioxovalerate
- Purity
- 97%
- Packaging
- 5g
- Price
- $72.2
- Updated
- 2023/06/20
- Product number
- R0165
- Product name
- Ethyl 2,4-Dioxovalerate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $106
- Updated
- 2025/07/31
- Product number
- R0165
- Product name
- Ethyl 2,4-Dioxovalerate
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $320
- Updated
- 2025/07/31
- Product number
- E916965
- Product name
- Ethyl 2,4-dioxovalerate
- Packaging
- 10g
- Price
- $110
- Updated
- 2021/12/16
Ethyl 2,4-dioxovalerate Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid
Uses
Ethyl 2,4-dioxovalerate was used in the preparation of:
- 1H-pyrazolo-[3,4-d]-pyridazin-7(6H)-one core analog
- pyrazole
General Description
Assymmmetric hydrogenation of ethyl 2,4-dioxovalerate in the presence of chiral rhodium or ruthenium catalysts yields 2-hydroxy-4-methyltetrahydrofuran-2-one. Ethyl 2,4-dioxovalerate is a potential anti-fungal agent.
Synthesis
95-92-1
67-64-1
615-79-2
1. Sodium ethoxide (30.0 g, 0.45 mol) was slowly added to 300 mL of anhydrous ethanol under the condition of an ice-salt bath and stirred uniformly. 2. Acetone (14.7 g, 0.3 mol) was pre-mixed with diethyl oxalate (46.7 g, 0.32 mol) to form a mixed solution. 3. Under the condition of keeping the reaction temperature lower than -5° C., the above mixed solution was added to the sodium-ethanol-ethanol solution dropwise with continuous stirring for 3 hours. 4. Upon completion of the reaction, the reaction mixture was slowly poured into ice-water. 5. Add the above mixed solution dropwise to the sodium ethanolate-ethanol solution with continuous stirring for 3 h. 4. Upon completion of the reaction, the reaction mixture was slowly poured into ice water. 5. Adjust the pH of the mixture with 1 mol/L hydrochloric acid to about 4. 6. Extract the aqueous phase using ethyl acetate (EA). 7. Combine the organic layers and wash twice with 150 mL of water, followed by drying with anhydrous sodium sulfate (Na2SO4). 8. The dried organic layer was filtered and concentrated under reduced pressure to give 46.5 g of a yellow liquid product (1a) in 94% yield and 96% purity. 9. The product 1a was used directly in the subsequent reaction without further purification. 10. A similar method can be used to synthesize compounds 1b-h.
References
[1] Chemical Papers, 2017, vol. 71, # 11, p. 2053 - 2061
[2] Heterocyclic Communications, 2017, vol. 23, # 6, p. 455 - 460
[3] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 2, p. 1121 - 1128
[4] Synthetic Communications, 2013, vol. 43, # 1, p. 110 - 117
[5] Monatshefte fur Chemie, 2003, vol. 134, # 9, p. 1221 - 1227
Ethyl 2,4-dioxovalerate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2,4-dioxovalerate manufacturers
- Product
- Ethyl 2,4-dioxovalerate 615-79-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-09-04
- Product
- Ethyl 2,4-dioxovalerate 615-79-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-08-27
- Product
- Ethyl 2,4-dioxovalerate 615-79-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02