Thevetiaflavone
- Product Name
- Thevetiaflavone
- CAS No.
- 29376-68-9
- Chemical Name
- Thevetiaflavone
- Synonyms
- Thevetiaflavone;5-O-METHYLAPIGENIN;Apigenin 5-methylether;Apigenin 5-O-monomethyl ether;4',7-Dihydroxy-5-methoxyflavone;Flavone,4',7-dihydroxy-5-methoxy- (8CI);Apigenin-5-methyl ether,5-0-Methylapigenin;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
- CBNumber
- CB2748959
- Molecular Formula
- C16H12O5
- Formula Weight
- 284.26
- MOL File
- Mol file
Thevetiaflavone Property
- Melting point:
- 263℃
- Boiling point:
- 567.9±50.0 °C(Predicted)
- Density
- 1.420
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 6.67±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AS027151
- Product name
- Thevetiaflavone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $316
- Updated
- 2021/12/16
- Product number
- CSN14606
- Product name
- Thevetiaflavone
- Packaging
- 1mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- CFN96124
- Product name
- Thevetiaflavone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $513
- Updated
- 2021/12/16
- Product number
- CSN14606
- Product name
- Thevetiaflavone
- Packaging
- 5mg
- Price
- $791
- Updated
- 2021/12/16
- Product number
- CD32001723
- Product name
- Thevetiaflavone
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $802
- Updated
- 2021/12/16
Thevetiaflavone Chemical Properties,Usage,Production
Uses
Thevetiaflavone inhibited the secretion of β-glucuronidase from neutrophils in rabbits, ED50 was 20μM. And it inhibited sarcoplasmic reticulum Ca2+-ATPase, when the concentration was 100μM, the inhibition rate was 69 %.
Preparation
The method for obtaining a refined extract from capers, comprising the following steps: a) making the concentrated capers crude extract go up to macroporous adsorption resin chromatography, and eluting with water and ethanol solution; b) eluting with ethanol solution , that is, the refined extract of capers.
Biological Activity
Thevetiaflavone can up-regulate the expression of Bcl-2 and down-regulate the expression of Bax and caspase-3.
in vivo
Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that it decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction , including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. It reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of the vetiaflavone in vivo and its application in the clinic.
Thevetiaflavone Preparation Products And Raw materials
Raw materials
Preparation Products
Thevetiaflavone Suppliers
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