Clomazone
- Product Name
- Clomazone
- CAS No.
- 81777-89-1
- Chemical Name
- Clomazone
- Synonyms
- Clomazon;dimethazone;2-(2-chlorobenzyl)-4,4-dimethyl-1,2-oxazolidin-3-one;gamit;COMMAND;Comazone;fmc57020;CLOMAZONE;Dimethazon;Isooxadiazon
- CBNumber
- CB2753003
- Molecular Formula
- C12H14ClNO2
- Formula Weight
- 239.7
- MOL File
- 81777-89-1.mol
Clomazone Property
- Melting point:
- 25°C
- Boiling point:
- 275.4°C
- Density
- 1.192
- refractive index
- 1.5388 (estimate)
- Flash point:
- 157 °C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMF: 33 mg/ml,DMSO: 16 mg/ml,Ethanol: 33 mg/ml,PBS (pH 7.2): 1 mg/ml
- form
- Solid
- pka
- -1.48±0.40(Predicted)
- color
- White to off-white
- Water Solubility
- 1.101g/L(temperature not stated)
- BRN
- 7480026
- InChIKey
- KIEDNEWSYUYDSN-UHFFFAOYSA-N
- CAS DataBase Reference
- 81777-89-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Dimethazone(81777-89-1)
- EPA Substance Registry System
- Clomazone (81777-89-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/22-36/38
- Safety Statements
- 26-36
- RIDADR
- 2902
- WGK Germany
- 2
- RTECS
- NY2977000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 81777-89-1(Hazardous Substances Data)
- Toxicity
- LD50 in male rats, female rats, mallard duck-bobwhite quail (mg/kg): 2077, 1369, >2510 orally; in rabbits (mg/kg): >2000 dermally (Chen)
N-Bromosuccinimide Price
- Product number
- CRM59694
- Product name
- Clomazone
- Purity
- certified reference material, <I>Trace</I><B>CERT</B><SUP>®</SUP>, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
- Packaging
- 100 mg
- Price
- $130
- Updated
- 2025/07/31
- Product number
- 46120
- Product name
- Clomazone
- Purity
- PESTANAL?, analytical standard
- Packaging
- 100mg
- Price
- $118
- Updated
- 2025/07/31
- Product number
- 59694
- Product name
- Clomazone
- Purity
- reference material
- Packaging
- 100MG
- Price
- $189
- Updated
- 2022/05/15
- Product number
- 23298
- Product name
- Clomazone
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 23298
- Product name
- Clomazone
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $87
- Updated
- 2024/03/01
Clomazone Chemical Properties,Usage,Production
Description
The molecular target site of clomazone has recently been determined. With clomazone, carotenoid synthesis is inhibited, but no intermediates in the carotenoidcommitted portion of the pathway accumulate (5,6). Synthesis of the derivatives of GGPP (gibberellic acid, phytol, carotenoids) is inhibited by clomazone (5–8). However, the synthesis of certain sesquiterpenoids and triterpenoids is not inhibited (9). Until recently, there was no credible report of the effect of clomazone on any enzyme of the terpenoid pathway (10–12). This was due to the fact that clomazone is a proherbicide and that the proper enzyme had not been tested.
Chemical Properties
Depending purity, it may be clear and colorless to pale yellow or brownish liquid. Commercially available as emulsifiable concentrates that can be dissolved in water
Uses
Herbicide.
Definition
ChEBI: A oxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2-chlorobenzyl group at position 2 and two methyl groups at position 4.
Hazard
Moderately toxic by ingestion, inhalation, and skin contact. A reproductive hazard.
Agricultural Uses
Herbicide: Clomazone is a broad-spectrum herbicide used on rice, peas, pumpkins, soybeans, sweet potatoes, winter squash, cotton, tobacco and fallow wheat fields to control annual grasses and broadleaf weeds.
Trade name
CERANO®; COLZOR TRIO®; COMMAND®; COMMENCE®, DIBEL®; FMC® 57020; GAMBIT®; MAGISTER®; MERIT®; STRATEGY®
Synthesis
611-19-8
81778-07-6
81777-89-1
1. 1000 kg of water was added to a 4000 L reactor followed by 460 kg of 4,4-dimethylisoxazolidin-3-one. The mixture was stirred for 1 hour at room temperature. 2. 383kg of sodium carbonate (Na2CO3) was added to the reaction mixture in small portions. The temperature of the mixture was raised to 85°C and the mixture was stirred continuously at this temperature for 2 hours. 3. 672 kg of o-chlorobenzyl chloride (2-chlorobenzyl chloride) was added slowly and dropwise over a period of 5 hours at 85°C. The mixture was kept at the same temperature for 2 hours. After the dropwise addition was completed, the temperature was maintained at 85°C until the reaction was complete. 4. The reaction mixture was cooled to room temperature, 800 kg of dichloromethane was added and stirred at room temperature for 15 hours. 5. The aqueous phase was separated and the aqueous phase was extracted three times with dichloromethane. 6. Recover the dichloromethane by distillation followed by addition of 2000 kg of hexane to the reactor. The mixture was refluxed for 1 hour, then cooled to 10-15 °C and continued stirring for 1 hour. 7. The solid product was separated by filtration, washed several times with hexane and finally dried under high vacuum to give pure 2-(2-chlorobenzyl)-4,4-dimethyloxazolidin-3-one (815 kg, purity: 96%). Note: Similar results were obtained using sodium hydroxide instead of sodium carbonate as base.
Potential Exposure
Clomazone is a oxazolidione broadspectrum herbicide used on rice, peas, pumpkins, soybeans, sweet potatoes, winter squash, cotton, tobacco, and fallow wheat fields to control annual grasses and broadleaf weeds.
Metabolic pathway
By the preparative incubation of clomazone with microorganisms that have the ability to metabolize clomazone, the metabolites are identified via major biotransformation reactions which involve hydroxylation at the 5-methylene carbon and one of the 3-methyl groups of the isoxazolidone ring and at the 3 0 -position of the phenyl ring. Minor metabolic routes include dihydroxylation on the phenyl ring, cleavage of the isoxazolinone ring, or complete removal of the isoxazolinone ring to form 2-chlorobenzyl alcohol. Under aerobic conditions of soils, degradation of clomazone proceeds primarily by CO2 evolution and the formation of bound soil residues. In flooded soils, clomazone is found rapidly to degrade via the formation of the reductive product N-[(2-chlorophenyl)methyl]-3-hydroxy-2,2- dimethylpropionamide. In tolerant soybean cell suspension cultures, the only metabolite identified is b-glycosyl-2-chlorobenzyl alcohol.
Shipping
UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
References
[1] Patent: WO2015/353, 2015, A1. Location in patent: Page/Page column 16; 17
[2] Patent: CN106749072, 2017, A. Location in patent: Paragraph 0018; 0021; 0024; 0027
Clomazone Preparation Products And Raw materials
Raw materials
Preparation Products
Clomazone Suppliers
- Tel
- 0510-86822183
- Fax
- 0086-510-86823825
- info@bailingcn.com
- Country
- China
- ProdList
- 6
- Advantage
- 58
- Tel
- 027-59102966 18717199209
- Fax
- 027-59379337
- 2853877583@qq.com
- Country
- China
- ProdList
- 2717
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 15527621225
- 1791901229@qq.com
- Country
- China
- ProdList
- 6945
- Advantage
- 52
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 025-846993838003-8003 18013301590
- Fax
- 025-84699383-8003
- njduly@126.com
- Country
- China
- ProdList
- 3249
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 022-65378550-8551
- Fax
- +86-022-2532-9655
- contact@altascientific.com
- Country
- China
- ProdList
- 2773
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9858
- Advantage
- 58
- Tel
- 022-6537-8550 15522853686
- Fax
- 022-2532-9655
- sales@altasci.com.cn
- Country
- China
- ProdList
- 4511
- Advantage
- 55
- Tel
- 021-50158063
- Fax
- 021-6153 1846
- sales@elivpharma.com
- Country
- China
- ProdList
- 477
- Advantage
- 58
- Tel
- 551-65418679 15837135945
- Fax
- 0551-65418697
- info@tnjchem.com
- Country
- China
- ProdList
- 1889
- Advantage
- 62
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9941
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- sales@njromanme.com
- Country
- China
- ProdList
- 4529
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 027-59402396 13419635609
- Fax
- 027-83989310
- 13419635609@163.com
- Country
- China
- ProdList
- 1992
- Advantage
- 55
- Tel
- 17792809151
- Fax
- 18872220797
- 2355916837@ycphar.com
- Country
- China
- ProdList
- 6133
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3932
- Advantage
- 58
- Tel
- +86-21-5877 1921
- Fax
- +86-21-5877 1925
- info@chemofchina.com
- Country
- China
- ProdList
- 9653
- Advantage
- 55
- Tel
- 021-021-52271985 17721149837
- Fax
- +86 (21) 52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 19800
- Advantage
- 60
- Tel
- 18064670521
- Fax
- 0757-88210752
- 2355935187@ycphar.com
- Country
- China
- ProdList
- 4879
- Advantage
- 58
- Tel
- 021-58950110 13124863828
- Fax
- 021-20922272
- sales@linkchem.cn
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 0755-85201366 18938635012
- Fax
- 0755-85201366
- sales@regentsciences.com
- Country
- China
- ProdList
- 9750
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 15001988657 15802146997
- info@bookchemicals.com
- Country
- China
- ProdList
- 950
- Advantage
- 58
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 1984
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 010-52889049
- 2250970673@qq.com
- Country
- CHINA
- ProdList
- 1132
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +86 18953170293
- Fax
- +86 0531-67809011
- sales@sdzschem.com
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- +86-13131129325
- Fax
- 86-0311-66562153
- sales1@chuanghaibio.com
- Country
- China
- ProdList
- 5249
- Advantage
- 58
- Tel
- +86-27-8746-5837 +8619945049750
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9629
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
View Lastest Price from Clomazone manufacturers
- Product
- Clomazone 81777-89-1
- Price
- US $0.00/kg
- Min. Order
- 100kg
- Purity
- 98
- Supply Ability
- 10000
- Release date
- 2025-09-28
- Product
- Clomazone 81777-89-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-11
- Product
- Clomazone 81777-89-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 96%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20