ChemicalBook > CAS DataBase List > (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID

(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID

Product Name: (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID
CAS No.: 72040-64-3
Chemical Name: (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID
Synonyms: BIOTIN-X;BIOTIN-LC;L-Gulono-1;Biotin-Hex-OH;(+)-Biotin-LC;CAS_72040-64-3;BIOTIN CAPROIC ACID;N-BIOTINYLCAPROIC ACID;D-BIOTIN-AMIDOCAPROIC ACID;6-BiotinaMidohexanoic Acid
CBNumber: CB2753674
Molecular Formula: C16H27N3O4S
Formula Weight: 357.47
MOL File: 72040-64-3.mol

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(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID Property

Melting point:: 220-230 °C (dec.)
Boiling point:: 721.3±55.0 °C(Predicted)
Density: 1.200±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly)
pka: 4.75±0.10(Predicted)
form: Solid
color: White
BRN: 706392
Stability:: Hygroscopic! Store Under Inert Atmosphere.
InChI: InChI=1S/C16H27N3O4S/c20-13(17-9-5-1-2-8-14(21)22)7-4-3-6-12-15-11(10-24-12)18-16(23)19-15/h11-12,15H,1-10H2,(H,17,20)(H,21,22)(H2,18,19,23)/t11-,12-,15-/m0/s1
InChIKey: CMUGHZFPFWNUQT-HUBLWGQQSA-N
SMILES: C(O)(=O)CCCCCNC(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 14407
Product name: N-(+)-Biotinyl-6-aminohexanoic acid
Purity: ≥97.0% (HPLC)
Packaging: 100mg
Price: $251
Updated: 2025/07/31

Sigma-Aldrich

Product number: 14407
Product name: N-(+)-Biotinyl-6-aminohexanoic acid
Purity: ≥97.0% (HPLC)
Packaging: 500mg
Price: $271.5
Updated: 2025/07/31

TCI Chemical

Product number: B2433
Product name: 6-Biotinamidohexanoic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 100mg
Price: $54
Updated: 2025/07/31

TRC

Product number: B395670
Product name: N-BiotinylcaproicAcid
Packaging: 1g
Price: $190
Updated: 2021/12/16

Usbiological

Product number: B1762
Product name: N-Biotinylcaproic Acid
Packaging: 100mg
Price: $326
Updated: 2021/12/16

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(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

amine reactive biotinylation reagent

Uses

An active Biotinylation reagent

Biological Activity

Biotinyl-6-aminohexanoic acid (Biotin-X) may be used in the biosynthesis of biotinylated oligosaccharides. Biotinyl-6-aminohexanoic acid is frequently used as a derivative of N-hydroxysuccinimide ester.

Synthesis

35013-72-0

60-32-2

72040-64-3

The general procedure for the synthesis of N-biotinocaproic acid from 2,5-dioxopyrrolidin-1-yl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate and 6-aminohexanoic acid is as follows: ε-aminohexanoic acid (966 mg, 8.4 mmol) was dissolved in 30 mL of 1 M NaHCO3 aqueous solution . Subsequently, N-hydroxysuccinimide biotin (3.09 g) dissolved in 35 mL of DMF was slowly added dropwise to this solution and the reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, some of the solvent was removed by concentration under reduced pressure, then 150 mL of aqueous citric acid (100 g/L) was added and stirred at 60 °C for 30 min. The precipitate was collected by filtration and washed with distilled water. The resulting precipitate was dissolved in a solvent mixture of isopropanol and water (8:2, v/v) and stored at 4 °C to finally obtain pure N-biotin hexanoic acid (1.455 g, 50% yield) as pale yellow crystals. The product was detected by IR (KBr) showing characteristic absorption peaks: 3200-3500, 3070, 2932, 2859, 1696, 1644, 1543, 1475, 1391, 1324, 1265, 1118 cm-1. 1H NMR (600 MHz, DMSO-d6) data: δ 7.75 (1H, t, J = 5.4 Hz, C6-NH), 6.45 (1H, s, C13-NH), 6.38 (1H, s, C14-NH), 4.35-4.27 (1H, m, H-14), 4.12 (1H, m, H-13), 3.09 (1H, m, H-12), 3.00 (1H, m, H-6), 2.82 (1H, dd, J = 12.4, 5.1 Hz, H-15a), 2.57 (1H, d, J = 12.4 Hz, H-15b), 2.19 (2H, t, J = 7.4 Hz, H-2), 2.04 (2H, t, J = 7.3 Hz, H-8), 1.20-1.67 (14H, m).13C NMR (150 MHz, DMSO-d6) data: δ 171.84 (C-1, C-7), 162.74 (C-16), 61.06 (C-13), 59.20 (C-14), 55.44 (C-12), 39.68 (C-15), 38.25 (C-6), 35.21 (C-8), 29.05 (C-2), 28.92, 28.21, 28.04, 26.04, 25.73, 25.36.

References

[1] Chemical Communications, 2009, # 33, p. 5030 - 5032
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 219 - 228
[3] RSC Advances, 2018, vol. 8, # 57, p. 32775 - 32793

(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID Suppliers

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View Lastest Price from (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-(+)-Biotinyl-6-aminohexanoic acid 72040-64-3
Price: US $0.00/g
Min. Order: 1g
Purity: 97%min H-NMR
Supply Ability: 100G
Release date: 2021-08-09

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-LC 72040-64-3
Price: US $0.00/mg
Min. Order: 250mg
Purity: >95.00%
Supply Ability: 5g
Release date: 2024-03-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID 72040-64-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

72040-64-3, (+)-BIOTIN-EPSILON-AMINOCAPROIC ACIDRelated Search:

3-[2-N-(BIOTINYL)AMINOETHYLDITHIO]PROPANOIC ACID 6-Aminocaproic acid N-(3-Azidopropyl)biotinaMide 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, (3aS,4S,6aR)- BIOTIN HPDP 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)- Biocytin FMOC-D-LYS(BIOTIN)-OH Succinimidyl 6-(biotinamido)hexanoate Hexanoic acid FMOC-LYS(BIOTIN)-OH 3-(N-MALEIMIDYLPROPIONYL)BIOCYTIN SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE 3-(4-(N-BIOTINOYL-6-AMINOCAPROYLOXY)PHENYL)PROPIONIC ACID, N-HYDROXYSUCCINIMIDE ESTER BOC-BIOCYTIN H-TYR-ILE-TYR-GLY-SER-PHE-LYS(BIOTIN) (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID BIOCYTIN HYDROCHLORIDE

D-BIOTIN-AMIDOCAPROIC ACID

BIOTIN-LC

BIOTIN CAPROIC ACID

(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID

BIOTIN-X

6-((BIOTINOYL)AMINO)HEXANOIC ACID

6-[(+)-BIOTINYL]AMINOCAPROIC ACID

6-[5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-4-YL)-PENTANOYLAMINO]-HEXANOIC ACID

CAS_72040-64-3

N-(+)-Biotinyl-6-amihexaic acid

N-(+)-BIOTINYL-6-AMINOCAPROIC ACID BIOTIN-X

N-(+)-BIOTINYL-6-AMINOHEXANOIC ACID

N-(+)-BIOTINYL-6-AMINOCAPROIC ACID

N-BIOTINYLCAPROIC ACID

(+)-Biotin-ε-aminocaproic acid, 6-((Biotinoyl)amino)hexanoic acid, Biotin-X, N-(+)-Biotinyl-6-aminocaproic acid

6-[(Biotinyl)amino]hexanoic acid

Biotin-6-aMinohexanoic acid

6-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]aMino]hexanoic Acid

6-[5-(2-Oxo-hexahydro-thieno[3,4-d]iMidazol-6-yl)-pentanoylaMino]-hexanoic acid

6-BiotinaMidohexanoic Acid

6-(5-((3AS,4S,6aR)-2-Oxohexahydro-1H-thieno-[3,4-d]imidazol-4-yl)pentanamido)hexanoic acid

(+)-Biotin-ω-aminocaproic acid

6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoic acid

Biotin-Hex-OH

(+) Biotinyl-6-aminohexanoic acid≥ 98% (HPLC)

6-BiotinamidohexanoicAcid&gt

Hexanoic acid, 6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-

(+)-Biotin-LC

N-(5-Carboxypentyl)biotinamide

72040-64-3 C16H27N3O4S (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID

L-Gulono-1

(+)Biotinyl-6-aminohexanoic acid

Biotin-LC [d-Biotin-amidocaproic acid] - 0.5 g

72040-64-3

C16H27N3O4S

Biotin Derivatives