Uses
ChemicalBook > CAS DataBase List > 3-(Trifluoromethyl)benzaldehyde

3-(Trifluoromethyl)benzaldehyde

Uses
Product Name
3-(Trifluoromethyl)benzaldehyde
CAS No.
454-89-7
Chemical Name
3-(Trifluoromethyl)benzaldehyde
Synonyms
MTF-BAD;3-(three fluoroMethyl;Cinacalcet Impurity 56;3-TRIFLUORMETHYLBENZALDEHYDE;m-Trifuoromethylbenzaldehyde;M-TRIFLUOROMETHYLBENZALDEHYDE;3-TRIFLUOROMETHYLBENZYLDEHYDE;Alpha-Trifluoro-M-tolualdehyde;A,A,A-TRIFLUORO-3-TOLUALDEHYDE;A,A,A-TRIFLUORO-M-TOLUALDEHYDE
CBNumber
CB2759919
Molecular Formula
C8H5F3O
Formula Weight
174.12
MOL File
454-89-7.mol
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3-(Trifluoromethyl)benzaldehyde Property

Boiling point:
83-86 °C30 mm Hg(lit.)
Density 
1.301 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.465(lit.)
Flash point:
155 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless to very slightly orange
Specific Gravity
1.301
Sensitive 
Air Sensitive
BRN 
2327537
InChIKey
NMTUHPSKJJYGML-UHFFFAOYSA-N
CAS DataBase Reference
454-89-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 3-(trifluoromethyl)-(454-89-7)
EPA Substance Registry System
Benzaldehyde, 3-(trifluoromethyl)- (454-89-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)
WGK Germany 
3
F 
10-23
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196878
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
97%
Packaging
25g
Price
$42.8
Updated
2024/03/01
Sigma-Aldrich
Product number
196878
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
97%
Packaging
5g
Price
$61.8
Updated
2024/03/01
TCI Chemical
Product number
T1399
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
>95.0%(GC)
Packaging
5g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
T1399
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
>95.0%(GC)
Packaging
25g
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
A10463
Product name
3-(Trifluoromethyl)benzaldehyde, 97%
Packaging
5g
Price
$48.65
Updated
2024/03/01
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3-(Trifluoromethyl)benzaldehyde Chemical Properties,Usage,Production

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY ORANGE LIQUID

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-╬│-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 426, 1946 DOI: 10.1021/ja01207a024

General Description

Aldol reaction of 3-(trifluoromethyl)benzaldehyde with hydroxyacetone in the aldolase antibody 38C2-ionic liquid system has been investigated.

3-(Trifluoromethyl)benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

3-(3-Trifluoromethylphenyl)propionic acid
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View Lastest Price from 3-(Trifluoromethyl)benzaldehyde manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
3-(Trifluoromethyl)benzaldehyde 454-89-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-21
Shaanxi Dideu Medichem Co. Ltd
Product
3-(Trifluoromethyl)benzaldehyde 454-89-7
Price
US $20.00-7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-06
Shaanxi Dideu Medichem Co. Ltd
Product
3-(Trifluoromethyl)benzaldehyde 454-89-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000Tons
Release date
2024-08-04

454-89-7, 3-(Trifluoromethyl)benzaldehydeRelated Search:

2-Methylbenzotrifluoride Benzaldehyde 3-Aminobenzotrifluoride 2-(Trifluoromethyl)benzoic acid (Trifluoromethyl)trimethylsilane 3-(Trifluoromethyl)anisole 3-(Trifluoromethyl)benzoyl chloride 3-Trifluoromethylphenol 3-(Trifluoromethyl)phenylacetone 3-(Trifluoromethyl)benzoic acid Trifluoromethanesulfonic acid p-Tolualdehyde 4-(Trifluoromethoxy)benzaldehyde 4-(Trifluoromethyl)benzoic acid alpha,alpha,alpha-Trifluoro-o-toluoyl chloride 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 1-NAPHTHALEN-2-YL-ETHYLAMINE 3-(3-METHYLPHENYL)PROPIONIC ACID

  • m-Trifluoromethoxy benzaldehyde
  • 3-Formylbenzotrifluoride, alpha,alpha,alpha-Trifluoro-3-tolualdehyde
  • Alpha-Trifluoro-M-tolualdehyde
  • 3-(TrifluoroMethyl)benzaldehyde, 97% 25GR
  • 3-(TrifluoroMethyl)benzaldehyde, 97% 5GR
  • 3-Formylbenzotrifluoride, alpha,alpha,alpha-Trifluoro-m-tolualdehyde
  • 3-(three fluoroMethyl)benzeneforMaldehyde
  • Between the three groups in benzene forMaldehyde
  • alpha,alpha,alpha-Trifluoro-m-toluylaldehyde
  • 3-TRIFLUORMETHYLBENZALDEHYDE
  • 3-(TRIFLUOROMETHYL)BENZALDEHYDE
  • A,A,A-TRIFLUORO-3-TOLUALDEHYDE
  • A,A,A-TRIFLUORO-M-TOLUALDEHYDE
  • alpha,alpha,alpha-Trifluoro-3-tolualdehyde
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUALDEHYDE
  • Cinacalcet Impurity 56
  • BENZOTRIFLUORIDE-3-CARBALDEHYDE
  • MTF-BAD
  • M-TRIFLUOROMETHYLBENZALDEHYDE
  • 3-(trifluoromethyl)-benzaldehyd
  • m-Tolualdehyde, alpha,alpha,alpha-trifluoro-
  • m-Trifluoromethylbenzaldehyde 3-Trifluoromethyl Benzaldehyde
  • 3-TRIFLUOROMETHYLBENZYLDEHYDE
  • m-Trifluoromethylbenzaldehyde,97%
  • à,à,à-trifluoro-m-tolualdehyde
  • 3-(Trifluoromethyl)benzaldehyde98%
  • A,A,A-TRIFLUORO-META-TOLUALDEHYDE
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-META-TOLUALDEHYDE
  • α,α,α-Trifluoro-m-toluylaldehyde
  • m-Trifuoromethylbenzaldehyde
  • Benzaldehyde, 3-(trifluoromethyl)-
  • 3-(Trifluoromethyl)benzaldehyde,97%
  • 3-(three fluoroMethyl
  • 3-(Trifluorzomethyl)Benzaldehyde
  • trifluoromethylbenzaldehyde-13C6
  • 454-89-7
  • 455-89-7
  • 454-89-1
  • 454-89-71
  • 455-89-7
  • C8H5F3O
  • ALDEHYDE
  • Organic Building Blocks
  • Aldehydes
  • Building Blocks
  • Carbonyl Compounds
  • C8
  • Benzotrifluoride Series
  • Aromatic Aldehydes & Derivatives (substituted)
  • Benzaldehyde
  • 3-(Trifluoromethyl)benzaldehyde
  • bc0001