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ISOLIQUIRITIN

Product Name
ISOLIQUIRITIN
CAS No.
5041-81-6
Chemical Name
ISOLIQUIRITIN
Synonyms
Isoliquiritoside;neoisoliquritin;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one;Aids004475;Aids-004475;ISOLIQUIRITIN;Isoliquiriiin;Isoliquiritin-RM;Isoliquiritin, >=98%;ISOLIQUIRITIN USP/EP/BP
CBNumber
CB2765101
Molecular Formula
C21H22O9
Formula Weight
418.39
MOL File
5041-81-6.mol
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ISOLIQUIRITIN Property

Melting point:
185-186℃
Boiling point:
743.5±60.0 °C(Predicted)
Density 
1.528
storage temp. 
4°C, protect from light
solubility 
Soluble in methan
form 
powder
pka
7.46±0.35(Predicted)
color 
Ochre
biological source
plant
InChI
InChI=1/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/s3
InChIKey
YNWXJFQOCHMPCK-RQOZFYCLNA-N
SMILES
[C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1=CC=C(/C=C/C(=O)C2C=CC(O)=CC=2O)C=C1 |&1:0,1,3,4,6,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB01045
Product name
Isoliquiritin
Purity
≥90% (LC/MS-ELSD)
Packaging
1mg
Price
$313
Updated
2025/07/31
TCI Chemical
Product number
I1144
Product name
Isoliquiritin
Packaging
25MG
Price
$228
Updated
2025/07/31
Cayman Chemical
Product number
30270
Product name
Isoliquiritin
Packaging
25mg
Price
$573
Updated
2024/03/01
Cayman Chemical
Product number
30270
Product name
Isoliquiritin
Packaging
50mg
Price
$793
Updated
2024/03/01
Cayman Chemical
Product number
30270
Product name
Isoliquiritin
Packaging
5mg
Price
$178
Updated
2024/03/01
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ISOLIQUIRITIN Chemical Properties,Usage,Production

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice.

Uses

It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Definition

ChEBI: A monosaccharide derivative that is trans-chalcone substituted by hydroxy groups at positions 2' and 4' and a beta-D-glucopyranosyloxy group at position 4 respectively.

Biological Activity

Isoliquiritin triggers apoptotic cell death by increasing the levels of p53 and p21 in A549 non-small cell lung cancer cells while also inhibiting the p53-dependent pathway and revealing interactions with Akt activities. Futher, Isoliquiritin has demonstrated neuroprotective activity against oxidative stress and has the capability to restrain the growth of microbial pathogens.

in vivo

Isoliquiritin (0.31-3.1 mg/kg, i.p., once a day for 5 days) inhibits granuloma angiogenesis in mice[1].
Isoliquiritin (10-40 mg/kg, oral gavage) shows antidepressant-like effects in FST and TST tests in mice[2].
Isoliquiritin ((10 mg/kg/bw/day, p.o.) shows anti-oxidative and anti-Inflammatory properties, and relieves cationic BSA-Induced membranous glomerulonephritis in experimental rat model[5].

Animal Model:Mice in Forced Swimming Test (FST) and the Tail Suspension Test (TST)[2]
Dosage:10, 20 and 40 mg/kg
Administration:oral gavage
Result:Reduced the immobility time in the FST and TST in mice.
Increased 5-HT and NE level and Reduced the ratio of 5-HIAA/5-HT in the hippocampus, hypothalamus and cortex.

target

HIV

ISOLIQUIRITIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOLIQUIRITIN Suppliers

China 232 India 1 United Kingdom 3 United States 12 USA 1 Global 249
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
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View Lastest Price from ISOLIQUIRITIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Isoliquiritin 5041-81-6
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
isoliquiritin 5041-81-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
isoliquiritin 5041-81-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

5041-81-6, ISOLIQUIRITINRelated Search:

Isocyclosporin A 8-O-acetylharpagide eupatilin Isocorynoxeine Isoliensinine ISORHYNCHOPHYLLINE Isoginkgetin Glabridin Liguiritigenin-7-O-D-apiosyl-4’-O-D-glucoside Isoliquiritigenin LICOCHALCONE-A LIQUIRITIGENIN LIQUIRITIN(SH) isoliquiritin apioside ISOLIQUIRITIN HOMOORIENTIN Ifosfamide ISOPIMARIC ACID

  • ISOLIQUIRITIN
  • (E)-1-(2,4-Dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-2-propen-1-one
  • [(E)-2',4'-Dihydroxychalcone-4-yl]β-D-glucopyranoside
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(.beta.-D-glucopyranosyloxy)phenyl]-, (2E)-
  • Aids004475
  • Aids-004475
  • neoisoliquritin
  • 2',4,4'-Trihydroxychalcone 4-(beta-D-glucopyranoside)
  • 2',4,4'-Trihydroxychalcone 4-beta-D-glucopyranoside
  • Isoliquiritoside
  • 4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl beta-D-glucopyranoside
  • Isoliquiritin, >=98%
  • Isoliquiriiin
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-, (2E)-
  • Isoliquiritin（Isoliquiritoside）
  • ISOLIQUIRITIN USP/EP/BP
  • (E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one
  • 4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl b...
  • (E)-1-(2,4-Dihydroxyphenyl)-3-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one
  • Isoliquiritin-RM
  • 5041-81-6
  • sy
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products