Ascrinvacumab

Product Name: Ascrinvacumab
CAS No.: 1463459-96-2
Chemical Name: Ascrinvacumab
Synonyms: PF-03446962;Ascrinvacumab;Research Grade Ascrinvacumab;Research Grade Ascrinvacumab (DHE20501)
CBNumber: CB28080947
Formula Weight: 0
MOL File: Mol file

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Ascrinvacumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Ascrinvacumab Chemical Properties,Usage,Production

Uses

Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC)[1].

in vivo

Ascrinvacumab decreases human vessel density and improves antitumor efficacy when combined with bevacizumab (anti-VEGF) in mouse chimera tumor model^[1].

References

[1] van Meeteren LA, et al. Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 2012 May 25;287(22):18551-61. DOI:10.1074/jbc.M111.338103

Ascrinvacumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Ascrinvacumab Suppliers

China 17 United States 1 Global 18

ShangHai Biochempartner Co.,Ltd

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TargetMol Chemicals Inc.

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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Olix (Shanghai) Pharmaceutical Technology Co., Ltd

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1463459-96-2, AscrinvacumabRelated Search:

Lutikizumab Cadonilimab Astegolimab Pimurutamab Edobacomab Tilogotamab Lesofavumab clenoliximab Enlimomab Iparomlimab

Ascrinvacumab

Research Grade Ascrinvacumab (DHE20501)

PF-03446962

Research Grade Ascrinvacumab

1463459-96-2