ChemicalBook > CAS DataBase List > Ascrinvacumab
Ascrinvacumab
- Product Name
- Ascrinvacumab
- CAS No.
- 1463459-96-2
- Chemical Name
- Ascrinvacumab
- Synonyms
- PF-03446962;Ascrinvacumab;Research Grade Ascrinvacumab;Research Grade Ascrinvacumab (DHE20501)
- CBNumber
- CB28080947
- Formula Weight
- 0
- MOL File
- Mol file
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Ascrinvacumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Ascrinvacumab Chemical Properties,Usage,Production
Uses
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC)[1].
in vivo
Ascrinvacumab decreases human vessel density and improves antitumor efficacy when combined with bevacizumab (anti-VEGF) in mouse chimera tumor model[1].
References
[1] van Meeteren LA, et al. Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 2012 May 25;287(22):18551-61. DOI:10.1074/jbc.M111.338103
Ascrinvacumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Ascrinvacumab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
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