Spesolimab
- Product Name
- Spesolimab
- CAS No.
- 2097104-58-8
- Chemical Name
- Spesolimab
- Synonyms
- BI 655130;Spesolimab;Spesolimab (DHJ72801);Spesolimab (anti-IL-1RL2);Research Grade Spesolimab;Research Grade Spesolimab(DHJ72801)
- CBNumber
- CB28081111
- Formula Weight
- 0
- MOL File
- Mol file
Spesolimab Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- SLK-A2442
- Product name
- Spesolimab (Anti-IL-1RL2 / IL-36R)
- Purity
- 99%
- Packaging
- 1mg
- Price
- $447
- Updated
- 2026/05/26
- Product number
- SLK-A2442
- Product name
- Spesolimab (Anti-IL-1RL2 / IL-36R)
- Purity
- 99%
- Packaging
- 1mg*5
- Price
- $1321
- Updated
- 2026/05/26
- Product number
- SLK-A2442
- Product name
- Spesolimab (Anti-IL-1RL2 / IL-36R)
- Purity
- 99%
- Packaging
- 1mg*25
- Price
- $3962
- Updated
- 2026/05/26
- Product number
- HY-P99396
- Product name
- Spesolimab
- Purity
- 99.10%
- Packaging
- 1mg
- Price
- $409
- Updated
- 2026/05/26
- Product number
- HY-P99396
- Product name
- Spesolimab
- Purity
- 99.10%
- Packaging
- 5mg
- Price
- $1064
- Updated
- 2026/05/26
Spesolimab Chemical Properties,Usage,Production
Uses
Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways[1][2][3][4].
References
[1] Mrowietz U, et al. Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study. Dermatol Ther (Heidelb). 2021 Apr;11(2):571-585. DOI:10.1007/s13555-021-00504-0
[2] Geller S, et al. CCR4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders and its implications for diagnosis and treatment[C]//Journal of Investigative Dermatology. STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA: ELSEVIER SCIENCE INC, 2019, 139(9): B25-B25.
[3] Jennifer Ahlberg, et al. Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5). MAbs. 2019 Jul;11(5):956-964. DOI:10.1080/19420862.2019.1615345
[4] Rajkumar Ganesan, et al. Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.MAbs. 2017 Oct;9(7):1143-1154. DOI:10.1080/19420862.2017.1353853
Spesolimab Preparation Products And Raw materials
Raw materials
Preparation Products
Spesolimab Suppliers
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