2-Bromo-3-nitrophenol
- Product Name
- 2-Bromo-3-nitrophenol
- CAS No.
- 101935-40-4
- Chemical Name
- 2-Bromo-3-nitrophenol
- Synonyms
- 2-BroMo-3-nitropheno;2-BROMO-3-NITROPHENOL;Phenol, 2-broMo-3-nitro-;2-Bromo-3-nitrophenol 97+%;2-Bromo-3-nitrophenol, 95% (Custom work);(S)-1-phenyl-2-methoxyethylamine hydrochloride
- CBNumber
- CB2823311
- Molecular Formula
- C6H4BrNO3
- Formula Weight
- 218
- MOL File
- 101935-40-4.mol
2-Bromo-3-nitrophenol Property
- Melting point:
- 147.5°C
- Boiling point:
- 248°C
- Density
- 1.881
- refractive index
- 1.6090 (estimate)
- Flash point:
- 104°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- pka
- 7.39±0.25(Predicted)
- color
- Beige/brown
- InChI
- InChI=1S/C6H4BrNO3/c7-6-4(8(10)11)2-1-3-5(6)9/h1-3,9H
- InChIKey
- HRVRWIBVVHOHNN-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=CC([N+]([O-])=O)=C1Br
Safety
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B698003
- Product name
- 2-Bromo-3-nitrophenol
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB75974
- Product name
- 2-Bromo-3-nitrophenol
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-W005430
- Product name
- 2-Bromo-3-nitrophenol
- Packaging
- 5g
- Price
- $113
- Updated
- 2021/12/16
- Product number
- FB75974
- Product name
- 2-Bromo-3-nitrophenol
- Packaging
- 5G
- Price
- $350
- Updated
- 2021/12/16
- Product number
- OR70053
- Product name
- 2-Bromo-3-nitrophenol
- Purity
- 97+%
- Packaging
- 25g
- Price
- $464
- Updated
- 2021/12/16
2-Bromo-3-nitrophenol Chemical Properties,Usage,Production
Uses
In laboratory research and chemical synthesis, 2-bromo-3-nitrophenol is mainly used as a multifunctional organic synthesis intermediate and chiral structural unit.
Synthesis
603-85-0
101935-40-4
General procedure for the synthesis of 2-bromo-3-nitrophenol from 2-amino-3-nitrophenol: 2-amino-3-nitrophenol (5 g, 32.4 mmol) was dissolved in water (29.5 mL) and 1,4-dioxane (14.7 mL). The mixture was heated to reflux and hydrobromic acid (48%, 16.7 mL, 147 mmol) was added dropwise over 20 min. After addition, reflux was continued for 15 min. The reaction mixture was cooled to 0 °C (ice bath) and a solution of sodium nitrite (2.23 g, 32.3 mmol) in water (20 mL) was added over 30 min. Stirring was continued at 0 °C for 15 min, then the mixture was transferred to a pre-cooled jacketed dropping funnel (0 °C) and added dropwise to a stirred mixture of cuprous bromide (I) (5.34 g, 37.2 mmol) in water (29.5 mL) and hydrobromic acid (48%, 16.7 mL, 147 mmol). The reaction mixture was stirred at 0 °C for 15 min, then warmed to 60 °C, continued stirring for 15 min, cooled to room temperature, and stirred overnight. The reaction mixture was transferred to a partition funnel and extracted with ether (3 x 150 mL). The organic layers were combined, washed with brine (1 x 150 mL), dried (Na2SO3), filtered and concentrated to give the crude product (7.99 g) as a reddish brown oil. The crude product was extracted by fast column chromatography (1:25 ultrapure silica gel, 230-400 mesh, 40-60 mm, 60 ? ; CH2Cl2 as solvent) purified the crude product to afford pure 2-bromo-3-nitrophenol (45%, 3.16 g) as an orange-brown solid. Mass spectrum (MS) m/z: 217.8 (MH+). High performance liquid chromatography (HPLC, TFA) homogeneity at 220 nm: 97%.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Patent: JP2005/522501, 2005, A. Location in patent: Page/Page column 18
[3] Patent: WO2009/92590, 2009, A2. Location in patent: Page/Page column 69-70
[4] Patent: WO2009/109539, 2009, A2. Location in patent: Page/Page column 65; 66
[5] Patent: WO2004/103996, 2004, A1. Location in patent: Page 40
2-Bromo-3-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-3-nitrophenol manufacturers
- Product
- 2-Bromo-3-nitrophenol 101935-40-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-23