Methyl 2-amino-5-bromo-4-pyridinecarboxylate
- Product Name
- Methyl 2-amino-5-bromo-4-pyridinecarboxylate
- CAS No.
- 882499-87-8
- Chemical Name
- Methyl 2-amino-5-bromo-4-pyridinecarboxylate
- Synonyms
- METHYL 2-AMINO-5-BROMOISONICOTINATE;METHYL 2-AMINO-5-BROMOPYRIDINE-4-CARBOXYLATE;Methyltinate 2-amino-5-bromoisonico;Methyl 2-aMMino-5-broMoisonicotinate;METHYL-2-AMINO-5-BROMO-4-CARBOXYLATE;Methyl 2-amino-5-bromoisonicotinate 98%;2-Amino-5-bromoisonotinic acid methyl ester;METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE;2-AMino-5-broMoisonicotinic acid Methyl ester;2-amino-5-bromo-3-methyl-4-pyridinecarboxylate
- CBNumber
- CB2839871
- Molecular Formula
- C7H7BrN2O2
- Formula Weight
- 231.05
- MOL File
- 882499-87-8.mol
Methyl 2-amino-5-bromo-4-pyridinecarboxylate Property
- Boiling point:
- 311.5±37.0 °C(Predicted)
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.78±0.24(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C7H7BrN2O2/c1-12-7(11)4-2-6(9)10-3-5(4)8/h2-3H,1H3,(H2,9,10)
- InChIKey
- FJPDYKLTAURVRU-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C(C(OC)=O)=C1
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M328503
- Product name
- Methyl2-amino-5-bromoisonicotinate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- M328503
- Product name
- Methyl2-amino-5-bromoisonicotinate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR3789
- Product name
- Methyl2-amino-5-bromoisonicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 056494
- Product name
- Methyl 2-amino-5-bromopyridine-4-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $524
- Updated
- 2021/12/16
- Product number
- HCH0014189
- Product name
- METHYL 2-AMINO-5-BROMOISONICOTINATE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $683.53
- Updated
- 2021/12/16
Methyl 2-amino-5-bromo-4-pyridinecarboxylate Chemical Properties,Usage,Production
Uses
Methyl 2-amino-5-bromo-4-pyridinecarboxylate is a halogenated derivative of pyridinecarboxylate. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
6937-03-7
882499-87-8
Step 15.1: Synthesis of methyl 2-amino-5-bromoisonicotinate. Methyl 2-aminoisonicotinate (5.58 g, 36.7 mmol) was dissolved in DMF (56 mL) and cooled to -18°C (using an ice/MeOH bath). At -18 °C, N-bromosuccinimide (NBS, 7.21 g, 38.5 mmol) was added to the reaction mixture in batches and stirred for 1 h at the same temperature. After completion of the reaction, the mixture was diluted with ethyl acetate (AcOEt, 500 mL) and washed with water (2 x 250 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product methyl 2-amino-5-bromoisonicotinate (3.0 g, 13.0 mmol, 35% yield) as a yellow solid, which was used directly in the next reaction without further purification. Mass spectrometry (MS): m/z 231 [M + H]+; high performance liquid chromatography (HPLC): retention time (Rt) = 0.70 min.
References
[1] Patent: WO2007/113226, 2007, A1. Location in patent: Page/Page column 126-127
[2] Patent: US2006/84802, 2006, A1. Location in patent: Page/Page column 29
Methyl 2-amino-5-bromo-4-pyridinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-amino-5-bromo-4-pyridinecarboxylate manufacturers
- Product
- METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE 882499-87-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE 882499-87-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-28
- Product
- METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE 882499-87-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10