ChemicalBook > CAS DataBase List > Methyl 2-amino-5-bromo-4-pyridinecarboxylate

Methyl 2-amino-5-bromo-4-pyridinecarboxylate

Product Name
Methyl 2-amino-5-bromo-4-pyridinecarboxylate
CAS No.
882499-87-8
Chemical Name
Methyl 2-amino-5-bromo-4-pyridinecarboxylate
Synonyms
METHYL 2-AMINO-5-BROMOISONICOTINATE;METHYL 2-AMINO-5-BROMOPYRIDINE-4-CARBOXYLATE;Methyltinate 2-amino-5-bromoisonico;Methyl 2-aMMino-5-broMoisonicotinate;METHYL-2-AMINO-5-BROMO-4-CARBOXYLATE;Methyl 2-amino-5-bromoisonicotinate 98%;2-Amino-5-bromoisonotinic acid methyl ester;METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE;2-AMino-5-broMoisonicotinic acid Methyl ester;2-amino-5-bromo-3-methyl-4-pyridinecarboxylate
CBNumber
CB2839871
Molecular Formula
C7H7BrN2O2
Formula Weight
231.05
MOL File
882499-87-8.mol
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Methyl 2-amino-5-bromo-4-pyridinecarboxylate Property

Boiling point:
311.5±37.0 °C(Predicted)
Density 
1.662±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.78±0.24(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C7H7BrN2O2/c1-12-7(11)4-2-6(9)10-3-5(4)8/h2-3H,1H3,(H2,9,10)
InChIKey
FJPDYKLTAURVRU-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C(C(OC)=O)=C1
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M328503
Product name
Methyl2-amino-5-bromoisonicotinate
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
M328503
Product name
Methyl2-amino-5-bromoisonicotinate
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR3789
Product name
Methyl2-amino-5-bromoisonicotinate
Purity
98%
Packaging
5g
Price
$138
Updated
2021/12/16
Matrix Scientific
Product number
056494
Product name
Methyl 2-amino-5-bromopyridine-4-carboxylate
Purity
>95%
Packaging
5g
Price
$524
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0014189
Product name
METHYL 2-AMINO-5-BROMOISONICOTINATE
Purity
95.00%
Packaging
500MG
Price
$683.53
Updated
2021/12/16
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Methyl 2-amino-5-bromo-4-pyridinecarboxylate Chemical Properties,Usage,Production

Uses

Methyl 2-amino-5-bromo-4-pyridinecarboxylate is a halogenated derivative of pyridinecarboxylate. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

6937-03-7

882499-87-8

Step 15.1: Synthesis of methyl 2-amino-5-bromoisonicotinate. Methyl 2-aminoisonicotinate (5.58 g, 36.7 mmol) was dissolved in DMF (56 mL) and cooled to -18°C (using an ice/MeOH bath). At -18 °C, N-bromosuccinimide (NBS, 7.21 g, 38.5 mmol) was added to the reaction mixture in batches and stirred for 1 h at the same temperature. After completion of the reaction, the mixture was diluted with ethyl acetate (AcOEt, 500 mL) and washed with water (2 x 250 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product methyl 2-amino-5-bromoisonicotinate (3.0 g, 13.0 mmol, 35% yield) as a yellow solid, which was used directly in the next reaction without further purification. Mass spectrometry (MS): m/z 231 [M + H]+; high performance liquid chromatography (HPLC): retention time (Rt) = 0.70 min.

References

[1] Patent: WO2007/113226, 2007, A1. Location in patent: Page/Page column 126-127
[2] Patent: US2006/84802, 2006, A1. Location in patent: Page/Page column 29

Methyl 2-amino-5-bromo-4-pyridinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-amino-5-bromo-4-pyridinecarboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE 882499-87-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Dideu Industries Group Limited
Product
METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE 882499-87-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE 882499-87-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

882499-87-8, Methyl 2-amino-5-bromo-4-pyridinecarboxylateRelated Search:

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