2-Chloroisonicotinaldehyde
- Product Name
- 2-Chloroisonicotinaldehyde
- CAS No.
- 101066-61-9
- Chemical Name
- 2-Chloroisonicotinaldehyde
- Synonyms
- 2-chloro-3-forMylpyridine-4-carboxylic acid;oroisonicotinaL;BUTTPARK 154\50-03;TIMTEC-BB SBB004156;2-Chloroisonicotinal;2-Chloronicotinealdehyde;2-CHLORO-4-FORMYLPYRIDINE;2-CHLOROISONICOTINALDEHYDE;CHLORO-2-FORMYL-3-PYRIDINE;2-Chloroisonicotinaldehyde 97%
- CBNumber
- CB2852601
- Molecular Formula
- C6H4ClNO
- Formula Weight
- 141.56
- MOL File
- 101066-61-9.mol
2-Chloroisonicotinaldehyde Property
- Melting point:
- 46-50 °C
- Boiling point:
- 243.4±20.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- Flash point:
- >230 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -1.23±0.10(Predicted)
- color
- White to Almost white
- Sensitive
- Air Sensitive
- BRN
- 7986625
- InChI
- InChI=1S/C6H4ClNO/c7-6-3-5(4-9)1-2-8-6/h1-4H
- InChIKey
- UFPOSTQMFOYHJI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C=O)=C1
- CAS DataBase Reference
- 101066-61-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36-43-36/37/38-20/21/22-42/43
- Safety Statements
- 26-36/37-36/37/39-22-45-23
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 707333
- Product name
- 2-Chloro-4-pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $44.5
- Updated
- 2025/07/31
- Product number
- 689734
- Product name
- 2-Chloro-4-pyridinecarboxaldehyde
- Purity
- technical, ≥90%
- Packaging
- 500mg
- Price
- $100
- Updated
- 2025/07/31
- Product number
- C2723
- Product name
- 2-Chloro-4-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- C2723
- Product name
- 2-Chloro-4-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $312
- Updated
- 2025/07/31
- Product number
- 707333
- Product name
- 2-Chloro-4-pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $106
- Updated
- 2023/06/20
2-Chloroisonicotinaldehyde Chemical Properties,Usage,Production
Chemical Properties
white to yellow solid
Uses
2-Chloropyridine-4-carboxaldehyde is a reagent used in the chemoenzymic synthesis of α-fluoro β-hydroxy carboxylic esters. It is also a reagent in the combinatorial synthesis of methylene sulfonamides and related compounds as potential kinase inhibitors.
Synthesis
100704-10-7
101066-61-9
The general procedure for the synthesis of 2-chloropyridine-4-carboxaldehyde from 2-chloro-4-hydroxymethylpyridine was as follows: in a 250 mL three-necked flask equipped with a cryogenic thermometer and two constant-pressure dropping funnels, a dichloromethane (15 mL) solution of oxalyl dichloride (1.24 g, 9.81 mmol) was added. The reaction system was cooled to -78 °C under nitrogen protection and stirred. The first constant pressure dropping funnel was connected to the nitrogen line and a dichloromethane (15 mL) solution of 2-chloro-4-hydroxymethylpyridine (0.94 g, 6.54 mmol) was added. A solution of anhydrous dimethyl sulfoxide (1.7 mL, 19.63 mmol) in dichloromethane (2 mL) was added to the other dropping funnel, and the solution was slowly added dropwise (25 min), keeping the reaction temperature between -60°C and -70°C. After the dropwise addition, the reaction system was slowly warmed up to -60 °C over 20 min, and then a dichloromethane solution of 2-chloro-4-hydroxymethylpyridine was added dropwise (50 min), maintaining the temperature between -50 °C and -60 °C. Subsequently, the reaction mixture was warmed to -45 °C over 30 min. The dropping funnel was washed with dichloromethane (2 x 5 mL) and a solution of triethylamine (480 μL, 6.51 mmol) in dichloromethane (4 mL) was added to the reaction mixture (10 min), and finally the mixture in the reaction flask was warmed up to 0 °C within 10 min. The reaction solution was transferred to a 500 mL dispensing funnel and 130 mL of 5% NH4Cl aqueous solution was added. The two phases were separated and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, washed with 1 M phosphate buffer (pH=7; 4×100 mL), dried over MgSO4, filtered and concentrated. 2-Chloropyridine-4-carbaldehyde was obtained as an orange solid (0.740 g, 76% yield). Product characterization: mw: 141.57; yield: 76%; orange solid. rf: 0.35 (EtOAc:cyclohexane=30:70). 1H-NMR (CDCl3, δ): 7.65 (dd, 1H, J=5.0 Hz, J=1.3 Hz, ArH), 7.75 (d, 1H, J=1.3 Hz, ArH), 8.66 (d. 1H, J=5.0 Hz, ArH), 10.05 (s, 1H, CHO).
References
[1] Patent: WO2008/11478, 2008, A2. Location in patent: Page/Page column 77-78
[2] Patent: US6218537, 2001, B1
2-Chloroisonicotinaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloroisonicotinaldehyde manufacturers
- Product
- 2-Chloroisonicotinaldehyde 101066-61-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-02
- Product
- 2-Chloroisonicotinaldehyde 101066-61-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-Chloroisonicotinaldehyde 101066-61-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08