2-Fluoro-5-bromoanisole
- Product Name
- 2-Fluoro-5-bromoanisole
- CAS No.
- 103291-07-2
- Chemical Name
- 2-Fluoro-5-bromoanisole
- Synonyms
- 2-fluoro-bromoanisole;2-fluoro-5-bromoanisole;2-FLUORO-5-BROMO ANISOLE,=98%;4-Bromo-1-fluoro-2-methoxybenzene;Benzene,4-broMo-1-fluoro-2-Methoxy;4-Bromo-1-fluoro-2-methoxybenzene, 5-Bromo-2-fluorophenyl methyl ether
- CBNumber
- CB2854827
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 103291-07-2.mol
2-Fluoro-5-bromoanisole Property
- Boiling point:
- 205.8±20.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- Appearance
- Colorless to off-white Liquid
- InChIKey
- SEVMQEIGENUPIE-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B685780
- Product name
- 5-Bromo-2-fluoroanisole
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 021386
- Product name
- 5-Bromo-2-fluoroanisole
- Purity
- 98%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- R200
- Product name
- 2-Fluoro-5-bromoanisole
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- PC2913
- Product name
- 5-Bromo-2-fluoroanisole
- Purity
- 98%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 2607-B-70
- Product name
- 5-Bromo-2-fluoroanisole
- Purity
- 98%
- Packaging
- 5G
- Price
- $26
- Updated
- 2021/12/16
2-Fluoro-5-bromoanisole Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Uses
5-Bromo-2-fluoroanisole is a reactant used in the preparation of bicyclic substituted hydroxyphenylmethanone derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis.
Synthesis
112204-58-7
74-88-4
103291-07-2
5-Bromo-2-fluorophenol (13.0 g, 68.1 mmol) and iodomethane (19.3 g, 136 mmol) were dissolved in DMF (120 mL) and potassium carbonate (18.8 g, 136 mmol) was added. The reaction mixture was stirred at room temperature for 65 hours. After completion of the reaction, water (150 mL) was added to the reaction solution and extracted with ethyl acetate (100 mL x 1,50 mL x 2). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give a light yellow oily crude product (29.0 g). The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10:1) to afford 5-bromo-2-fluoroanisole (14.2 g, yield: quantitative) in colorless oily form. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) and 19F-NMR (376 MHz, CDCl3): 1H-NMR δ 3.88 (s, 3H), 6.95 (dd, J = 8.6 and 10.8 Hz, 1H), 7.02 (ddd, J = 2.2,4.2 and 8.6 Hz, 1H), 7.08 (dd. J = 2.2 and 7.6 Hz, 1H); 19F-NMR δ -137 (s, 1F).
References
[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0452; 0453
[2] Patent: WO2006/76246, 2006, A2. Location in patent: Page/Page column 87
[3] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[4] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71
2-Fluoro-5-bromoanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-5-bromoanisole manufacturers
- Product
- 2-Fluoro-5-bromoanisole 103291-07-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-21
- Product
- 2-Fluoro-5-bromoanisole 103291-07-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25