ChemicalBook > CAS DataBase List > (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

Product Name
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
CAS No.
28416-82-2
Chemical Name
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
Synonyms
FluMethasone acid;Fluticasone Acid;Axon 1170;impurity J;BNKY011-FP01;BNKY012-FF01;Flumetasone acid;flumethason acid;(6a,11b,16a,17a)-6;17-carboxylic acid
CBNumber
CB2854948
Molecular Formula
C21H26F2O5
Formula Weight
396.42
MOL File
28416-82-2.mol
More
Less

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Property

Melting point:
303-305°C
Boiling point:
568.4±50.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.49±0.70(Predicted)
color 
White to Off-White
More
Less

Safety

HS Code 
2937220000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
50mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
500mg
Price
$535
Updated
2024/03/01
Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
100mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
250mg
Price
$302
Updated
2024/03/01
TRC
Product number
F599490
Product name
Fluticasone17β-CarboxylicAcid
Packaging
100mg
Price
$135
Updated
2021/12/16
More
Less

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Chemical Properties,Usage,Production

Description

Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate .

Chemical Properties

White Solid

Uses

The major metabolite of Fluticasone. Anti-inflammatory agent.

Uses

Fluticasone intermediate. Anti-inflammatory agent

General Description

Fluticasone 17β-carboxylic acid ((6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid) is a compound of interest in studying structure-activity relationships within corticosteroid analogs. In research, this compound is examined for its potential interactions with glucocorticoid receptors, given its structural similarity to fluticasone, which is known for its affinity to these receptors. The 17β-carboxylic acid moiety may alter the compound's binding characteristics. In biochemistry, fluticasone 17β-carboxylic acid is used to probe the metabolic pathways of fluticasone, as it may be a metabolite or intermediate.

Synthesis

To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (Fluticasone 17β-Carboxylic Acid) as a colorless solid.

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Suppliers

Canada 1 China 212 India 8 The Netherlands 1 United States 9 Global 231
Wuhan DKY Technology Co.,Ltd.
Tel
027-81302411 15377658509
Email
zs@dkybpc.com
Country
China
ProdList
2216
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8835
Advantage
52
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2859
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18097
Advantage
56
Suzhou Laing Biological Technology Co., LTD
Tel
0512-62968256 18550502935
Fax
0512-62968256
Email
export@laingbiotec.com
Country
China
ProdList
1124
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11662
Advantage
59
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Lianyungang TengFa Biological Technology Co. Ltd
Tel
0518-85475186 18705131893
Fax
0518-85475186
Email
wang666xt@163.com
Country
China
ProdList
351
Advantage
55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q3252066219
Fax
QQ3382968513
Email
danping@shsendpharm.com
Country
China
ProdList
3100
Advantage
55
Jinan Putubio Tech Co., Ltd.
Tel
+86 (531) 8099-2215
Fax
+86 (531) 8099-2215
Email
putubio@outlook.com
Country
China
ProdList
1261
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Shijiazhuang yaoBo Pharmaceutical Co., Ltd.
Tel
15633056635
Email
2880679888@qq.com
Country
China
ProdList
3005
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangzhou Kafen Biotech Co.,Ltd
Tel
18029243487 2355327168
Fax
020-31121510
Email
gy@yccreate.com
Country
China
ProdList
4749
Advantage
55
Wuhai Shuou Technology Co., Ltd.
Tel
17792809151
Fax
18872220797
Email
2355916837@ycphar.com
Country
China
ProdList
6133
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4032
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9578
Advantage
60
Chengdu Saiousi Pharmaceutical Co., Ltd
Tel
028-64971018 18108168130
Fax
86 028-64971018
Country
China
ProdList
1781
Advantage
55
Wuhan Netcom Electronic Commerce Limited
Tel
18064670521
Fax
0757-88210752
Email
2355935187@ycphar.com
Country
China
ProdList
4879
Advantage
58
Zhuhai JiaYi Biological Technology Co., Ltd.
Tel
18578209868 2355327026
Fax
18578209868 QQ：2355327026
Email
steroidbest@hotmail.com
Country
China
ProdList
6501
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Wuhan Zeno Biological Technology Co., Ltd.
Tel
13657284589
Fax
027-87781970
Email
znobio@qq.com
Country
China
ProdList
141
Advantage
58
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Shaanxi billion Kang Long biological technology co., LTD
Tel
17791478691
Fax
4009024560
Email
yklbiotech@163.com
Country
China
ProdList
409
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
10034
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
9120
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9639
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Hebei Yanxi Chemical Co., Ltd.
Tel
+8617531153977
Email
allison@yan-xi.com
Country
China
ProdList
5855
Advantage
58
Hebei Mujin Biotechnology Co.,Ltd
Tel
+86 13288715578 +8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12830
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12373
Advantage
58
Hubei Ipure Biology Co., Ltd
Tel
+8613367258412
Fax
18062427325
Email
ada@ipurechemical.com
Country
China
ProdList
10319
Advantage
58
Shijiazhuang Tongyang Import and Export Co., LTD
Tel
18031361688;
Email
admin@sjztongyang.com
Country
China
ProdList
977
Advantage
58
More
Less

View Lastest Price from (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid manufacturers

Moxin Chemicals
Product
Fluticasone Carboxylic Acid 28416-82-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98
Supply Ability
10000
Release date
2025-01-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Fluticasone Carboxylic Acid 28416-82-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-29
Hebei Yanxi Chemical Co., Ltd.
Product
flumethasone 28416-82-2
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-20

28416-82-2, (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acidRelated Search:

Kresoxim-methyl Methylparaben Acetonitrile Allyl methacrylate Methyl acetate Methyl acrylate Methanol Mesityl oxide METHYLCYCLOPENTADIENE DIMER Basic Violet 1 6-Methyl-5-hepten-2-one Paraquat dichloride Methyl cyclopentenolone Flumethasone Fluorometholone Methyl Methyl bromide Fluticasone

  • impurity J
  • 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methylpregna- 3-oxo-1,4-diene-17b-carboxylic Acid
  • Fluticasone 17b-Carboxylic Acid
  • 6A,9A-DIFLUORO-11SS,17A-DIHYDROXY-3-OXOANDROSTA-1,4-DIENE-17SS-CARBOXYLIC ACID
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6ALPHA,11BETA,16ALPHA,17ALPHA)-
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6A,11SS,16A,17A)-
  • (6a,11,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
  • 6a,9a-Difluoro-11,17a-dihydroxy-16a-methylpregna-3-oxo-1,4-diene-17-carboxylic Acid
  • Fluticasone 17-Carboxylic Acid
  • 6α,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
  • Fluticasone Impurity 11(Fluticasone USP RC J)
  • Fluticasone USP RC J
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-M
  • 6a,9a-difluoro-11 P,17a-dihydroxy-16a-methyl-3- oxoandrosta-1,4-diene-17P-carboxylic acid
  • 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Discontinued see product # F599490
  • Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17- dihydroxy-16-Methyl-3-oxo-,(6|á,11|,16|á,17|á)-
  • (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-Methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
  • 6α,9α-Difluoro-11β,17α-dihydroxy-16α-Methylpregna- 3-oxo-1,4-diene-17β-carboxylic Acid
  • (6A,11B,16A,17A)-6,9-DIFLUORO-11,17-diHYDROXY-16-METHY1-3-OXOANDROSTA-1,4-DIENE-17-CAR
  • FluMethasone acid
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-DIFLUORO-11,17-DIHYDRO
  • Fluticasone propionate Intermediates (Flumethasone acid)
  • Fluticasone Carboxylic Acid
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxyl
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6α,11β,16α,17α)-
  • 6a,9a-Difluoro-1117a-dihydroxy-3-oxoandrosta-1,4-diene-17carboxylic Acid Discontinued see product # F599490
  • Axon 1170
  • Fluticasone 17-beta-Carboxylic Acid
  • BNKY011-FP01
  • BNKY012-FF01
  • Propionate Impurity J
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)
  • Fluticasone Acid
  • Fluticasone USP Related Compound J
  • Fluticasone IMpurity J
  • Fluticasone Propionate Impurity 1
  • 1,4-diene-17-carboxylic acid
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid [Flumethasone Acid]
  • 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid Discontinued see product # F599490
  • Fluticasone 17β-Carboxylic Acid
  • Flumetasone acid
  • FLUMETHASONE ACID /CAS NO.:28416-82-2
  • 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid Discontinued see F599490
  • 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
  • Fluticasone Related Compound J
  • Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)-
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-ox...
  • (6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
  • Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha (1285818)
  • flumethason acid
  • Fluticasone Propionate USP Related Compound J
  • (6a,11b,16a,17a)-6
  • Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-
  • 17-carboxylic acid