ChemicalBook > CAS DataBase List > (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

Product Name
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
CAS No.
28416-82-2
Chemical Name
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
Synonyms
FluMethasone acid;Fluticasone Acid;Axon 1170;impurity J;BNKY011-FP01;BNKY012-FF01;Flumetasone acid;flumethason acid;(6a,11b,16a,17a)-6;17-carboxylic acid
CBNumber
CB2854948
Molecular Formula
C21H26F2O5
Formula Weight
396.42
MOL File
28416-82-2.mol
More
Less

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Property

Melting point:
303-305°C
Boiling point:
568.4±50.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.49±0.70(Predicted)
color 
White to Off-White
More
Less

Safety

HS Code 
2937220000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
50mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
500mg
Price
$535
Updated
2024/03/01
Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
100mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
27855
Product name
Fluticasone 17β-Carboxylic Acid
Packaging
250mg
Price
$302
Updated
2024/03/01
TRC
Product number
F599490
Product name
Fluticasone17β-CarboxylicAcid
Packaging
100mg
Price
$135
Updated
2021/12/16
More
Less

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Chemical Properties,Usage,Production

Description

Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate .

Chemical Properties

White Solid

Uses

The major metabolite of Fluticasone. Anti-inflammatory agent.

Uses

Fluticasone intermediate. Anti-inflammatory agent

General Description

Fluticasone 17β-carboxylic acid ((6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid) is a compound of interest in studying structure-activity relationships within corticosteroid analogs. In research, this compound is examined for its potential interactions with glucocorticoid receptors, given its structural similarity to fluticasone, which is known for its affinity to these receptors. The 17β-carboxylic acid moiety may alter the compound's binding characteristics. In biochemistry, fluticasone 17β-carboxylic acid is used to probe the metabolic pathways of fluticasone, as it may be a metabolite or intermediate.

Synthesis

To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (Fluticasone 17β-Carboxylic Acid) as a colorless solid.

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Suppliers

Canada 1 China 209 India 8 The Netherlands 1 United States 9 Global 228
Wuhan DKY Technology Co.,Ltd.
Tel
027-81302411 15377658509
Email
zs@dkybpc.com
Country
China
ProdList
2196
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
More
Less

View Lastest Price from (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
flumethasone 28416-82-2
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Fluticasone Carboxylic Acid 28416-82-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-29
Zibo Hangyu Biotechnology Development Co., Ltd
Product
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 28416-82-2
Price
US $80.00-800.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-06

28416-82-2, (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acidRelated Search:

Kresoxim-methyl Methylparaben Acetonitrile Allyl methacrylate Methyl acetate Methyl acrylate Methanol Mesityl oxide METHYLCYCLOPENTADIENE DIMER Basic Violet 1 6-Methyl-5-hepten-2-one Paraquat dichloride Methyl cyclopentenolone Flumethasone Fluorometholone Methyl Methyl bromide Fluticasone

  • impurity J
  • 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methylpregna- 3-oxo-1,4-diene-17b-carboxylic Acid
  • Fluticasone 17b-Carboxylic Acid
  • 6A,9A-DIFLUORO-11SS,17A-DIHYDROXY-3-OXOANDROSTA-1,4-DIENE-17SS-CARBOXYLIC ACID
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6ALPHA,11BETA,16ALPHA,17ALPHA)-
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6A,11SS,16A,17A)-
  • (6a,11,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
  • 6a,9a-Difluoro-11,17a-dihydroxy-16a-methylpregna-3-oxo-1,4-diene-17-carboxylic Acid
  • Fluticasone 17-Carboxylic Acid
  • 6α,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
  • Fluticasone Impurity 11(Fluticasone USP RC J)
  • Fluticasone USP RC J
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-M
  • 6a,9a-difluoro-11 P,17a-dihydroxy-16a-methyl-3- oxoandrosta-1,4-diene-17P-carboxylic acid
  • 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Discontinued see product # F599490
  • Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17- dihydroxy-16-Methyl-3-oxo-,(6|á,11|,16|á,17|á)-
  • (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-Methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
  • 6α,9α-Difluoro-11β,17α-dihydroxy-16α-Methylpregna- 3-oxo-1,4-diene-17β-carboxylic Acid
  • (6A,11B,16A,17A)-6,9-DIFLUORO-11,17-diHYDROXY-16-METHY1-3-OXOANDROSTA-1,4-DIENE-17-CAR
  • FluMethasone acid
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-DIFLUORO-11,17-DIHYDRO
  • Fluticasone propionate Intermediates (Flumethasone acid)
  • Fluticasone Carboxylic Acid
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxyl
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6α,11β,16α,17α)-
  • 6a,9a-Difluoro-1117a-dihydroxy-3-oxoandrosta-1,4-diene-17carboxylic Acid Discontinued see product # F599490
  • Axon 1170
  • Fluticasone 17-beta-Carboxylic Acid
  • BNKY011-FP01
  • BNKY012-FF01
  • Propionate Impurity J
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)
  • Fluticasone Acid
  • Fluticasone USP Related Compound J
  • Fluticasone IMpurity J
  • Fluticasone Propionate Impurity 1
  • 1,4-diene-17-carboxylic acid
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid [Flumethasone Acid]
  • 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid Discontinued see product # F599490
  • Fluticasone 17β-Carboxylic Acid
  • Flumetasone acid
  • FLUMETHASONE ACID /CAS NO.:28416-82-2
  • 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid Discontinued see F599490
  • 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
  • Fluticasone Related Compound J
  • Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)-
  • (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-ox...
  • (6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
  • Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha (1285818)
  • flumethason acid
  • Fluticasone Propionate USP Related Compound J
  • (6a,11b,16a,17a)-6
  • Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-
  • Fluticasone Propionate Impurity 6