ChemicalBook > CAS DataBase List > (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- Product Name
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- CAS No.
- 28416-82-2
- Chemical Name
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- Synonyms
- FluMethasone acid;Fluticasone Acid;Axon 1170;impurity J;BNKY011-FP01;BNKY012-FF01;Flumetasone acid;flumethason acid;(6a,11b,16a,17a)-6;17-carboxylic acid
- CBNumber
- CB2854948
- Molecular Formula
- C21H26F2O5
- Formula Weight
- 396.42
- MOL File
- 28416-82-2.mol
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(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Property
- Melting point:
- 303-305°C
- Boiling point:
- 568.4±50.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.49±0.70(Predicted)
- color
- White to Off-White
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Safety
- HS Code
- 2937220000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 27855
- Product name
- Fluticasone 17β-Carboxylic Acid
- Packaging
- 50mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27855
- Product name
- Fluticasone 17β-Carboxylic Acid
- Packaging
- 500mg
- Price
- $535
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27855
- Product name
- Fluticasone 17β-Carboxylic Acid
- Packaging
- 100mg
- Price
- $130
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27855
- Product name
- Fluticasone 17β-Carboxylic Acid
- Packaging
- 250mg
- Price
- $302
- Updated
- 2024/03/01
TRC
- Product number
- F599490
- Product name
- Fluticasone17β-CarboxylicAcid
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
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(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Chemical Properties,Usage,Production
Description
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate .
Chemical Properties
White Solid
Uses
The major metabolite of Fluticasone. Anti-inflammatory agent.
Uses
Fluticasone intermediate. Anti-inflammatory agent
General Description
Fluticasone 17β-carboxylic acid ((6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid) is a compound of interest in studying structure-activity relationships within corticosteroid analogs. In research, this compound is examined for its potential interactions with glucocorticoid receptors, given its structural similarity to fluticasone, which is known for its affinity to these receptors. The 17β-carboxylic acid moiety may alter the compound's binding characteristics. In biochemistry, fluticasone 17β-carboxylic acid is used to probe the metabolic pathways of fluticasone, as it may be a metabolite or intermediate.
Synthesis
To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (Fluticasone 17β-Carboxylic Acid) as a colorless solid.
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Suppliers
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- India
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View Lastest Price from (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- flumethasone 28416-82-2
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-20
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Fluticasone Carboxylic Acid 28416-82-2
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-29
Zibo Hangyu Biotechnology Development Co., Ltd
- Product
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 28416-82-2
- Price
- US $80.00-800.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-06
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