2,4-Dichloro-3-methylpyridine
- Product Name
- 2,4-Dichloro-3-methylpyridine
- CAS No.
- 132097-09-7
- Chemical Name
- 2,4-Dichloro-3-methylpyridine
- Synonyms
- 2,4-Dichloro-3-picoline;2,4-Dichlor-3-methylpyridin;2,4-Dichloro-3-methylpyridine;Pyridine, 2,4-dichloro-3-methyl-;2,4-Dichloro-3-methylpyridine 98%;2,4-DICHLORO-3-METHYLPYRIDINE, 98+%;2,4-Dichloro-3-methylpyridine ISO 9001：2015 REACH
- CBNumber
- CB2874939
- Molecular Formula
- C6H5Cl2N
- Formula Weight
- 162.02
- MOL File
- 132097-09-7.mol
2,4-Dichloro-3-methylpyridine Property
- Boiling point:
- 218.7±35.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.38±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- CAS DataBase Reference
- 132097-09-7(CAS DataBase Reference)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D435480
- Product name
- 2,4-Dichloro-3-methylpyridine
- Packaging
- 2.5g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- FD21622
- Product name
- 2,4-Dichloro-3-methylpyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD21622
- Product name
- 2,4-Dichloro-3-methylpyridine
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR315126
- Product name
- 2,4-Dichloro-3-methylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 3H32-5-CT
- Product name
- 2,4-Dichloro-3-methylpyridine
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
2,4-Dichloro-3-methylpyridine Chemical Properties,Usage,Production
Uses
2,4-Dichloro-3-methylpyridine is Used for preparation of imidazo[4,5-b]pyridine derivatives for treatment of diseases caused by gastric acid.
Synthesis
74-88-4
132097-09-7
A hexane solution of 1.6 M n-butyllithium (3.75 mL, 6.0 mmol) and anhydrous tetrahydrofuran (5 mL) were added to a flame-dried flask under nitrogen protection. The reaction system was cooled to -78 °C and 2,4-dichloropyridine (6.0 mmol) was added slowly dropwise under stirring, keeping the stirring at -78 °C for 30 min. Subsequently, iodomethane (0.374 mL, 6.0 mmol) was added slowly and dropwise at the same temperature. The reaction mixture was continued to be stirred at -78 °C for 1 h. Then glacial acetic acid (0.114 mL, 2.0 mmol) was added to adjust the pH to 5-6 (wet pH paper test). The reaction mixture was dissolved in ether (100 mL), the organic phase was washed sequentially with water (10 mL) and saturated brine (10 mL), and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product as an oil. Purification by fast column chromatography with the eluent being petroleum ether:dichloromethane (50:50, v/v) to petroleum ether:dichloromethane:ethyl acetate (50:47:3, v/v/v) afforded 2,4-dichloro-3-methylpyridine as a white solid (589 mg, 72% yield). Note: 2,4-dichloro-3-methylpyridine sublimates readily under reduced pressure.1H NMR (CD3OD, 400 MHz) δ 8.15 (d, 1H), 7.46 (d, 1H), 2.50 (s, 3H).LRMS (ESI) m/z: Calculated value C6H5Cl2N [M+H]+ 160.98, measured value 161.9.
References
[1] Patent: WO2005/7647, 2005, A1. Location in patent: Page/Page column 183; 184
2,4-Dichloro-3-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dichloro-3-methylpyridine Suppliers
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- United Kingdom
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View Lastest Price from 2,4-Dichloro-3-methylpyridine manufacturers
- Product
- 2,4-Dichlor-3-methylpyridin 132097-09-7
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-11
- Product
- 2,4-Dichloro-3-methylpyridine 132097-09-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25
- Product
- 2,4-Dichloro-3-methylpyridine 132097-09-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07