3,5-Dichloro-4-Picoline
- Product Name
- 3,5-Dichloro-4-Picoline
- CAS No.
- 100868-46-0
- Chemical Name
- 3,5-Dichloro-4-Picoline
- Synonyms
- 3,5-Dichloro-4-Picoline;3,5-Dichloro-4-methylpyridine;Pyridine,3,5-dichloro-4-Methyl-;3,5-Dichloro-4-methylpyridine 97%;3,5-Dichloro-4-Picoline ISO 9001：2015 REACH
- CBNumber
- CB31033107
- Molecular Formula
- C6H5Cl2N
- Formula Weight
- 162.02
- MOL File
- 100868-46-0.mol
3,5-Dichloro-4-Picoline Property
- Melting point:
- 49 °C
- Boiling point:
- 125-127 °C(Press: 74 Torr)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.62±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C6H5Cl2N/c1-4-5(7)2-9-3-6(4)8/h2-3H,1H3
- InChIKey
- YBHYECGRNFZJPC-UHFFFAOYSA-N
- SMILES
- C1=NC=C(Cl)C(C)=C1Cl
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D435688
- Product name
- 3,5-Dichloro-4-methylpyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD146967
- Product name
- 3,5-Dichloro-4-methylpyridine
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FD146967
- Product name
- 3,5-Dichloro-4-methylpyridine
- Packaging
- 2g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- OR61509
- Product name
- 3,5-Dichloro-4-methylpyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $129
- Updated
- 2021/12/16
- Product number
- FD146967
- Product name
- 3,5-Dichloro-4-methylpyridine
- Packaging
- 5G
- Price
- $140
- Updated
- 2021/12/16
3,5-Dichloro-4-Picoline Chemical Properties,Usage,Production
Synthesis
2457-47-8
74-88-4
100868-46-0
Example 6 (Scheme 1) Preparation of 3,5-dichloro-4-methylpyridine (4): diisopropylamine (70 mL, 500 mmol) was dissolved in anhydrous tetrahydrofuran (500 mL) under nitrogen protection, and the resultant solution was cooled to -10 °C and n-butyllithium (2.5 M hexane solution, 210 mL, 525 mmol) was added slowly dropwise under stirring. After the dropwise addition, stirring was continued for 30 min at -10 °C. Subsequently, the reaction system was further cooled to -20 °C and a tetrahydrofuran (200 mL) solution of 3,5-dichloropyridine (66.6 g, 450 mmol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at -10 °C for 30 min. Next, the reaction system was cooled to -70 °C and a tetrahydrofuran (100 mL) solution of iodomethane (50 mL, 1.6 mol) was added dropwise. After the dropwise addition, the reaction mixture was slowly warmed up to room temperature. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL) and extracted with ether (3 x 100 mL). The organic layers were combined, dried over anhydrous sodium sulfate (5 g), filtered and concentrated to dryness under reduced pressure. The crude product was recrystallized by two recrystallizations from aqueous ethanol followed by hexane to give 3,5-dichloro-4-methylpyridine (49.9 g, 306 mmol, 68% yield) as a white solid.
References
[1] Patent: EP2070913, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: EP2022783, 2009, A1. Location in patent: Page/Page column 12
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 793 - 816
3,5-Dichloro-4-Picoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dichloro-4-Picoline manufacturers
- Product
- 3,5-Dichloro-4-Picoline 100868-46-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 3,5-Dichloro-4-Picoline 100868-46-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 3,5-Dichloro-4-Picoline 100868-46-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-27