2,6-Dichloro-4-picoline
- Product Name
- 2,6-Dichloro-4-picoline
- CAS No.
- 39621-00-6
- Chemical Name
- 2,6-Dichloro-4-picoline
- Synonyms
- 6-Dichloro-4-picoline;2,6-Dichloro-4-picoline;2,6-Dichloro-4-methylpyri...;Pyridine,2,6-dichloro-4-Methyl-;2,6-Dichloro-4-methylpyridine,95%;2,6-Dichloro-4-picoline ISO 9001：2015 REACH
- CBNumber
- CB1947115
- Molecular Formula
- C6H5Cl2N
- Formula Weight
- 162.02
- MOL File
- 39621-00-6.mol
2,6-Dichloro-4-picoline Property
- Melting point:
- 65.0-66.0 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 122-123 °C(Press: 22-23 Torr)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- -2.22±0.10(Predicted)
- color
- White
- InChI
- InChI=1S/C6H5Cl2N/c1-4-2-5(7)9-6(8)3-4/h2-3H,1H3
- InChIKey
- GTHRJKYVJZJPCF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(C)=C1
- CAS DataBase Reference
- 39621-00-6
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D435263
- Product name
- 2,6-Dichloro-4-methylpyridine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 070088
- Product name
- 2,6-Dichloro-4-methylpyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- W5996
- Product name
- 2,6-Dichloro-4-picoline
- Packaging
- 5g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 070088
- Product name
- 2,6-Dichloro-4-methylpyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- W5996
- Product name
- 2,6-Dichloro-4-picoline
- Packaging
- 25g
- Price
- $101
- Updated
- 2021/12/16
2,6-Dichloro-4-picoline Chemical Properties,Usage,Production
Chemical Properties
off-white solid
Uses
2,6-Dichloro-4-methylpyridine is used in preparation of substituted phenoxymethyl benzoic acids and related products as modulators of Mas-related G-protein receptor X4.
Synthesis
52313-61-8
39621-00-6
General procedure for the synthesis of 2,6-dichloro-4-methylpyridine from 2-chloro-4-methylpyridine-N-oxide: 2-chloro-4-methylpyridine-N-oxide was added to a 50mL round-bottomed flask, and 20mL of phosphorus oxychloride (POCl3) was added slowly and dropwise. (Note: the reaction is exothermic and slow addition of N-oxide to POCl3 is required to avoid violent reaction.) Subsequently, an additional 10 mL of POCl3 was added to the reaction mixture and the reaction system was heated to 95°C and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and volatiles were removed by distillation under reduced pressure. The residue was slowly poured into 150 mL of saturated sodium bicarbonate (NaHCO3) aqueous solution and extracted with ethyl acetate (EtOAc, 3 x 50 mL). The organic phases were combined, washed with 50 mL of saturated brine and dried over anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure and the resulting brown solid was purified by fast column chromatography on silica gel (eluent: 0 to 7% ethyl acetate/hexane gradient) to afford 1.56 g of the target product 2,6-dichloro-4-methylpyridine in 43% yield.
References
[1] Patent: US2004/198736, 2004, A1. Location in patent: Page/Page column 76
[2] Patent: US2011/9390, 2011, A1. Location in patent: Page/Page column 19
[3] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 1056
2,6-Dichloro-4-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dichloro-4-picoline manufacturers
- Product
- 2,6-Dichloro-4-picoline 39621-00-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2,6-Dichloro-4-picoline 39621-00-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2,6-Dichloro-4-picoline 39621-00-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-27