ChemicalBook > CAS DataBase List > 2,6-Dichloro-4-picoline

2,6-Dichloro-4-picoline

Product Name
2,6-Dichloro-4-picoline
CAS No.
39621-00-6
Chemical Name
2,6-Dichloro-4-picoline
Synonyms
6-Dichloro-4-picoline;2,6-Dichloro-4-picoline;2,6-Dichloro-4-methylpyri...;Pyridine,2,6-dichloro-4-Methyl-;2,6-Dichloro-4-methylpyridine,95%;2,6-Dichloro-4-picoline ISO 9001：2015 REACH
CBNumber
CB1947115
Molecular Formula
C6H5Cl2N
Formula Weight
162.02
MOL File
39621-00-6.mol
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2,6-Dichloro-4-picoline Property

Melting point:
65.0-66.0 °C(Solv: ligroine (8032-32-4))
Boiling point:
122-123 °C(Press: 22-23 Torr)
Density 
1.319±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
Solid
pka
-2.22±0.10(Predicted)
color 
White
InChI
InChI=1S/C6H5Cl2N/c1-4-2-5(7)9-6(8)3-4/h2-3H,1H3
InChIKey
GTHRJKYVJZJPCF-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C)=C1
CAS DataBase Reference
39621-00-6
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D435263
Product name
2,6-Dichloro-4-methylpyridine
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
070088
Product name
2,6-Dichloro-4-methylpyridine
Purity
97%
Packaging
5g
Price
$29
Updated
2021/12/16
AK Scientific
Product number
W5996
Product name
2,6-Dichloro-4-picoline
Packaging
5g
Price
$26
Updated
2021/12/16
Matrix Scientific
Product number
070088
Product name
2,6-Dichloro-4-methylpyridine
Purity
97%
Packaging
25g
Price
$89
Updated
2021/12/16
AK Scientific
Product number
W5996
Product name
2,6-Dichloro-4-picoline
Packaging
25g
Price
$101
Updated
2021/12/16
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2,6-Dichloro-4-picoline Chemical Properties,Usage,Production

Chemical Properties

off-white solid

Uses

2,6-Dichloro-4-methylpyridine is used in preparation of substituted phenoxymethyl benzoic acids and related products as modulators of Mas-related G-protein receptor X4.

Synthesis

52313-61-8

39621-00-6

General procedure for the synthesis of 2,6-dichloro-4-methylpyridine from 2-chloro-4-methylpyridine-N-oxide: 2-chloro-4-methylpyridine-N-oxide was added to a 50mL round-bottomed flask, and 20mL of phosphorus oxychloride (POCl3) was added slowly and dropwise. (Note: the reaction is exothermic and slow addition of N-oxide to POCl3 is required to avoid violent reaction.) Subsequently, an additional 10 mL of POCl3 was added to the reaction mixture and the reaction system was heated to 95°C and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and volatiles were removed by distillation under reduced pressure. The residue was slowly poured into 150 mL of saturated sodium bicarbonate (NaHCO3) aqueous solution and extracted with ethyl acetate (EtOAc, 3 x 50 mL). The organic phases were combined, washed with 50 mL of saturated brine and dried over anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure and the resulting brown solid was purified by fast column chromatography on silica gel (eluent: 0 to 7% ethyl acetate/hexane gradient) to afford 1.56 g of the target product 2,6-dichloro-4-methylpyridine in 43% yield.

References

[1] Patent: US2004/198736, 2004, A1. Location in patent: Page/Page column 76
[2] Patent: US2011/9390, 2011, A1. Location in patent: Page/Page column 19
[3] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 1056

2,6-Dichloro-4-picoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dichloro-4-picoline Suppliers

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View Lastest Price from 2,6-Dichloro-4-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,6-Dichloro-4-picoline 39621-00-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Fengda Chemical Co., Ltd
Product
2,6-Dichloro-4-picoline 39621-00-6
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Dideu Industries Group Limited
Product
2,6-Dichloro-4-picoline 39621-00-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-27

39621-00-6, 2,6-Dichloro-4-picoline Related Search:

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile METHYL 2,6-DICHLOROISONICOTINATE 2,6-DICHLOROPYRIDINE-4-CARBOXIMIDAMIDE HYDROCHLORIDE 2,6-Dichloro-4-(trifluoromethyl)pyridine 3,5-BIS(METHYLSULFONYL)ANILINE 2,6-DICHLOROPYRIDINE-4-CARBONYL CHLORIDE PYRIDINITRIL 3-Cyano-2,6-dichloro-GAMMA-picoline 2-Chloro-5-chloromethylpyridine 3,5-Dichloro-4-Picoline 4,5-DICHLORO-2-METHYLPYRIDINE 2,4-dichloro-5-methylpyridine 2,4-dichloro-5-picoline,2,4-Dichloro-5-Picoline 2,5-DICHLORO-3-PICOLINE 6-AMINO-3,5-DICHLORO-2-PICOLINE 2,6-Dichloro-3-methylpyridine 3,4-Dichloro-2-Picoline ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE 2,4-Dichloro-3-picoline

  • 2,6-Dichloro-4-picoline
  • 2,6-Dichloro-4-methylpyri...
  • Pyridine,2,6-dichloro-4-Methyl-
  • 2,6-Dichloro-4-methylpyridine,95%
  • 2,6-Dichloro-4-picoline ISO 9001：2015 REACH
  • 6-Dichloro-4-picoline
  • 39621-00-6
  • Pyridine