ChemicalBook > CAS DataBase List > 3,5-Dichloro-4-Picoline

3,5-Dichloro-4-Picoline

Product Name
3,5-Dichloro-4-Picoline
CAS No.
100868-46-0
Chemical Name
3,5-Dichloro-4-Picoline
Synonyms
3,5-Dichloro-4-Picoline;3,5-Dichloro-4-methylpyridine;Pyridine,3,5-dichloro-4-Methyl-;3,5-Dichloro-4-methylpyridine 97%;3,5-Dichloro-4-Picoline ISO 9001：2015 REACH
CBNumber
CB31033107
Molecular Formula
C6H5Cl2N
Formula Weight
162.02
MOL File
100868-46-0.mol
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3,5-Dichloro-4-Picoline Property

Melting point:
49 °C
Boiling point:
125-127 °C(Press: 74 Torr)
Density 
1.319±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
0.62±0.10(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C6H5Cl2N/c1-4-5(7)2-9-3-6(4)8/h2-3H,1H3
InChIKey
YBHYECGRNFZJPC-UHFFFAOYSA-N
SMILES
C1=NC=C(Cl)C(C)=C1Cl
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D435688
Product name
3,5-Dichloro-4-methylpyridine
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD146967
Product name
3,5-Dichloro-4-methylpyridine
Packaging
1g
Price
$40
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD146967
Product name
3,5-Dichloro-4-methylpyridine
Packaging
2g
Price
$70
Updated
2021/12/16
Apolloscientific
Product number
OR61509
Product name
3,5-Dichloro-4-methylpyridine
Purity
97%
Packaging
5g
Price
$129
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD146967
Product name
3,5-Dichloro-4-methylpyridine
Packaging
5G
Price
$140
Updated
2021/12/16
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3,5-Dichloro-4-Picoline Chemical Properties,Usage,Production

Synthesis

2457-47-8

74-88-4

100868-46-0

Example 6 (Scheme 1) Preparation of 3,5-dichloro-4-methylpyridine (4): diisopropylamine (70 mL, 500 mmol) was dissolved in anhydrous tetrahydrofuran (500 mL) under nitrogen protection, and the resultant solution was cooled to -10 °C and n-butyllithium (2.5 M hexane solution, 210 mL, 525 mmol) was added slowly dropwise under stirring. After the dropwise addition, stirring was continued for 30 min at -10 °C. Subsequently, the reaction system was further cooled to -20 °C and a tetrahydrofuran (200 mL) solution of 3,5-dichloropyridine (66.6 g, 450 mmol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at -10 °C for 30 min. Next, the reaction system was cooled to -70 °C and a tetrahydrofuran (100 mL) solution of iodomethane (50 mL, 1.6 mol) was added dropwise. After the dropwise addition, the reaction mixture was slowly warmed up to room temperature. Upon completion of the reaction, the reaction was quenched with deionized water (100 mL) and extracted with ether (3 x 100 mL). The organic layers were combined, dried over anhydrous sodium sulfate (5 g), filtered and concentrated to dryness under reduced pressure. The crude product was recrystallized by two recrystallizations from aqueous ethanol followed by hexane to give 3,5-dichloro-4-methylpyridine (49.9 g, 306 mmol, 68% yield) as a white solid.

References

[1] Patent: EP2070913, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: EP2022783, 2009, A1. Location in patent: Page/Page column 12
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 793 - 816

3,5-Dichloro-4-Picoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Dichloro-4-Picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3,5-Dichloro-4-Picoline 100868-46-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Henan Fengda Chemical Co., Ltd
Product
3,5-Dichloro-4-Picoline 100868-46-0
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Dideu Industries Group Limited
Product
3,5-Dichloro-4-Picoline 100868-46-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-27

100868-46-0, 3,5-Dichloro-4-PicolineRelated Search:

3,5-DICHLORO-4-PYRIDINECARBONITRILE 3,5-DICHLOROISONICOTINIC ACID 2-BROMO-3,5-DICHLOROISONICOTINIC ACID 2-AMINO-3,5-DICHLORO-4-PICOLINE 3,5-DICHLORO-4-FORMYL PYRIDINE 2-Chloro-5-chloromethylpyridine 2,5-DICHLORO-3-PICOLINE 2,4-dichloro-5-methylpyridine 2,4-dichloro-5-picoline,2,4-Dichloro-5-Picoline 3-Cyano-2,6-dichloro-GAMMA-picoline 6-AMINO-3,5-DICHLORO-2-PICOLINE 4,5-DICHLORO-2-METHYLPYRIDINE ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE 3,4-Dichloro-2-Picoline Picoplatin 2,4-Dichloro-3-picoline 2,3-DICHLORO-4-PICOLINE 2,3-DICHLORO-5-PICOLINE 2,6-Dichloro-4-picoline

  • 3,5-Dichloro-4-methylpyridine 97%
  • Pyridine,3,5-dichloro-4-Methyl-
  • 3,5-Dichloro-4-Picoline
  • 3,5-Dichloro-4-methylpyridine
  • 3,5-Dichloro-4-Picoline ISO 9001：2015 REACH
  • 100868-46-0
  • pharmacetical
  • Pyridine