Iothalamate meglumine
- Product Name
- Iothalamate meglumine
- CAS No.
- 13087-53-1
- Chemical Name
- Iothalamate meglumine
- Synonyms
- Cysto-Conray;EINECS 235-998-9;Meglumine conray;Meglumine iotalamate;Iothalamate Meglumine;N-Methylglucamine salt;Iotalamic acid meglumine;Iothalamic acid·meglumine;Methylglucamine iotalamate;Iotalamic acid meglumine salt
- CBNumber
- CB2921013
- Molecular Formula
- C11H9I3N2O4.C7H17NO5
- Formula Weight
- 809.115
- MOL File
- 13087-53-1.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
Iothalamate meglumine Chemical Properties,Usage,Production
Originator
Conray,Mallinckrodt Inc.,US,1962
Uses
Diagnostic aid (radiopaque medium).
Definition
ChEBI: Iothalamate meglumine is an amidobenzoic acid.
Manufacturing Process
Crude 5-amino-2,4,6-triiodo-N-methylisophthalamic acid (21.0 g) was
dissolved in warm dimethylacetamide (40 ml) and acetic anhydride (30 ml)
and concentrated sulfuric acid (2 drops) were added. This solution was heated
on the steam bath for 2 hours, then heated at 110°C for 5 minutes, then
cooled. Water and ammonium hydroxide were added to destroy the excess
acetic anhydride, after which the mixture was evaporated to a volume of 50
ml. The cooled solution was acidified with concentrated hydrochloric acid and
a tan solid was collected. The crude product was dissolved in 100 ml of water
containing a slight excess of sodium hydroxide. The pH was adjusted to 4.5
with acetic acid, and the solution was treated with charcoal. The colorless
solution was acidified with concentrated hydrochloric acid and cooled, and the
precipitate was filtered off and dried under reduced pressure. The resulting 5-
acetamido-2,4,6-triiodo-N-methylisophthalamic acid decomposes about 285°C
and does not melt below 300°C.
5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid was slurried in water
and dissolved by the addition of an equivalent quantity of N-methylglucamine.
The solution was evaporated to dryness to yield the meglumate salt of 5-
acetamido-2,4,6-triiodo-N-methylisophthalamic acid.
brand name
Conray(Mallinckrodt).
Therapeutic Function
Diagnostic aid (radiopaque medium)
General Description
Iothalamate meglumineis a high-osmolar, ionic monomer with 47% boundiodine content. Conray is indicated for use in angiography,excretory urography, arthrography, cholangiography, endoscopicretrograde cholangiopancreatography, and variousCT procedures.
Iothalamate meglumine Preparation Products And Raw materials
Raw materials
Preparation Products
Iothalamate meglumine Suppliers
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