ChemicalBook > CAS DataBase List > Chloramphenicol hemisuccinate

Chloramphenicol hemisuccinate

Product Name
Chloramphenicol hemisuccinate
CAS No.
3544-94-3
Chemical Name
Chloramphenicol hemisuccinate
Synonyms
Chronicin foam;Paraxin succinate;Kemicetine succinate;Levomycetin succinate;Chloromycetin succinate;Chloramphenicol succinate;Levomycetin hemisuccinate;Chloramphenicol 3-succinate;Chloramphenicol hemisuccinate;Chloramphenicol monosuccinate
CBNumber
CB2925965
Molecular Formula
C15H16Cl2N2O8
Formula Weight
423.2
MOL File
3544-94-3.mol
More
Less

Chloramphenicol hemisuccinate Property

Melting point:
127 °C
Boiling point:
716.3±60.0 °C(Predicted)
Density 
1.6769 (rough estimate)
refractive index 
1.7350 (estimate)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A solid
pka
4.36±0.17(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
25453
Product name
Chloramphenicol Succinate
Purity
≥99%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
25453
Product name
Chloramphenicol Succinate
Purity
≥99%
Packaging
25mg
Price
$433
Updated
2024/03/01
TRC
Product number
C325123
Product name
ChloramphenicolSuccinate
Packaging
10mg
Price
$105
Updated
2021/12/16
TRC
Product number
C325123
Product name
ChloramphenicolSuccinate
Packaging
5mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
0086BA
Product name
4-[2-[(Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoicacid
Packaging
25mg
Price
$580
Updated
2021/12/16
More
Less

Chloramphenicol hemisuccinate Chemical Properties,Usage,Production

Description

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol. It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro. Chloramphenicol succinate reduces human leukocyte migration in vitro. In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively. Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury. Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.

Uses

Chloramphenicol succinate is prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug. Chloramphenicol succinate represents an alternative pro-drug strategy for chloramphenicol that has found a niche in surface antibiotic treatment in surgery. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.

Definition

ChEBI: Chloramphenicol succinate is a member of amphetamines and a hemisuccinate.

Chloramphenicol hemisuccinate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Chloramphenicol hemisuccinate Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
More
Less

View Lastest Price from Chloramphenicol hemisuccinate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Chloramphenicol succinate 3544-94-3
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19

3544-94-3, Chloramphenicol hemisuccinateRelated Search:


  • [2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hydrogen [R-(R*,R*)]-succinate
  • Butanedioic acid hydrogen 1-[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester
  • Chloramphenicol 3-succinate
  • Succinic acid hydrogen 1-[(2R,3R)-3-(4-nitrophenyl)-2-(dichloroacetylamino)-3-hydroxypropan-1-yl] ester
  • ChloraMphenicol succinate, KeMicetine
  • Chloramphenicol succinate
  • Acetamide, 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, α-(hydrogen succinate), D-(-)-threo- (8CI)
  • Butanedioic acid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester
  • Butanedioic acid, mono[2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, [R-(R*,R*)]-
  • Chloramphenicol 3-monosuccinate
  • Chloramphenicol acid succinate
  • Chloramphenicol hemisuccinate
  • Chloramphenicol hydrogen succinate
  • Chloramphenicol monosuccinate
  • Chloromycetin succinate
  • Chronicin foam
  • Kemicetine succinate
  • Levomycetin hemisuccinate
  • Levomycetin succinate
  • Paraxin succinate
  • Succinic acid, ester with chloramphenicol (6CI)
  • Succinic acid, α-monoester with D-threo-(-)-2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]acetamide (8CI)
  • 4-[2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid
  • 4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoicaci
  • 3544-94-3
  • C15H16Cl2N2O8