ChemicalBook > CAS DataBase List > METHYL 5-BROMO-2-IODOBENZOATE

METHYL 5-BROMO-2-IODOBENZOATE

Application

Product Name: METHYL 5-BROMO-2-IODOBENZOATE
CAS No.: 181765-86-6
Chemical Name: METHYL 5-BROMO-2-IODOBENZOATE
Synonyms: 5-Bromo-2-iodobenzoate;5-Bromo-2-iodo-benzoic acid methyl ester;QCF4;Methyl 2-Iodo-5-Bromobenzoate;5-bromo-2-iodobenzoate methyl;Benzoic acid,5-broMo-2-iodo-, Methyl ester;Methyl 5-broMo-2-iodobenzoate;METHYL 5-BROMMETHYL 5-BROMO-2-IODOBENZOATEO-2-IODOBENZOATE
CBNumber: CB2972909
Molecular Formula: C8H6BrIO2
Formula Weight: 340.94
MOL File: 181765-86-6.mol

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METHYL 5-BROMO-2-IODOBENZOATE Property

Melting point:: 45-49 °C (lit.)
Boiling point:: 134°C/1mmHg(lit.)
Density: 2.059±0.06 g/cm3(Predicted)
Flash point:: 113℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
color: White to Orange to Green
InChIKey: CJRHLSZJEFJDLA-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 652601
Product name: Methyl 5-bromo-2-iodobenzoate
Purity: 97%
Packaging: 10g
Price: $165
Updated: 2025/07/31

TCI Chemical

Product number: M3084
Product name: Methyl 5-Bromo-2-iodobenzoate
Purity: >95.0%(GC)
Packaging: 1g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: M3084
Product name: Methyl 5-Bromo-2-iodobenzoate
Purity: >95.0%(GC)
Packaging: 5g
Price: $63
Updated: 2025/07/31

TRC

Product number: M220575
Product name: Methyl 5-bromo-2-iodobenzoate
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2623-S-X0
Product name: Methyl 5-bromo-2-iodobenzoate
Packaging: 5G
Price: $44
Updated: 2021/12/16

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METHYL 5-BROMO-2-IODOBENZOATE Chemical Properties,Usage,Production

Application

Methyl 5-bromo-2-iodobenzoate belongs to the benzoic acid derivatives and is mainly used as an intermediate in organic synthesis and pharmaceutical chemistry. It can be used to prepare preservatives, dyes, and drug molecules.

Chemical Properties

off-white powder

Synthesis

610-97-9

181765-86-6

Concentrated sulfuric acid (10 mL) was added dropwise to a stirred solution of methyl 2-iodobenzoate (5.0 g, 19.08 mmol, 1.0 eq.) and N-bromosuccinimide (NBS, 3.73 g, 20.99 mmol, 1.1 eq.) in acetic acid (10 mL), keeping the reaction temperature between 20-40 °C. The reaction mixture was stirred at room temperature for 88 hours and then warmed up to 50°C and continued stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to 10 °C and the reaction was quenched with cold water (40 mL) and subsequently extracted with dichloromethane (DCM, 3 x 50 mL). The organic layers were combined and washed sequentially with 5% sodium bicarbonate solution (2 × 50 mL), 10% sodium sulfite solution (50 mL), and water (50 mL), then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the crude product methyl 5-bromo-2-iodobenzoate. The crude product was purified by rapid column chromatography on silica gel, the eluent being a hexane solution of 10% ethyl acetate. The pure grade was collected and the solvent was evaporated under reduced pressure to give methyl 5-bromo-2-iodobenzoate as an off-white solid (5 g, 77% yield). NMR hydrogen spectrum (400 MHz, CDCl3) δppm: 3.94 (s, 3H), 7.26-7.29 (m, 1H), 7.83 (d, J=8.4 Hz, 1H), 7.93 (d, J=8.8 Hz, 1H).

References

[1] Patent: WO2018/15879, 2018, A1. Location in patent: Page/Page column 81
[2] Patent: US2004/92521, 2004, A1. Location in patent: Page/Page column 16-20; 46
[3] Patent: US2005/256118, 2005, A1. Location in patent: Page/Page column 18-19
[4] Patent: US2005/256309, 2005, A1. Location in patent: Page/Page column 20-21; 36
[5] Patent: US2005/272728, 2005, A1. Location in patent: Page/Page column 19-20

METHYL 5-BROMO-2-IODOBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 5-BROMO-2-IODOBENZOATE Suppliers

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View Lastest Price from METHYL 5-BROMO-2-IODOBENZOATE manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: methyl 5-bromo-2-iodobenzoate 181765-86-6
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-04-08

Kindchem(Nanjing)Co.,Ltd

Product: METHYL 5-BROMO-2-IODOBENZOATE 181765-86-6
Price: US $0.00-0.00/G
Min. Order: 10G
Purity: 0.98
Supply Ability: 500kg
Release date: 2023-09-28

Career Henan Chemical Co

Product: METHYL 5-BROMO-2-IODOBENZOATE 181765-86-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-31

181765-86-6, METHYL 5-BROMO-2-IODOBENZOATERelated Search:

METHYL 2-METHYL-5-FLUOROBENZOATE methyl 5-formyl-2-nitrobenzoate Methyl 5-broMo-2-fluoro-3-nitrobenzoate 5-BroMo-2,4-difluoro-benzoic acid Methyl ester Methyl 4-hydroxy-2-methylbenzoate Methyl 5-nitro-2-(trifluoromethyl)benzoate Methyl 5-aMino-2-iodobenzoate methyl 5-amino-2-(trifluoromethyl)benzoate methyl 4-bromo-2-formylbenzoate Methyl 4-bromo-2,6-dichlorobenzoate METHYL 4-FORMYL-3-HYDROXYBENZOATE METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 5-Bromo-6-methoxynicotinic acid methyl ester METHYL 5-BROMO-2-FUROATE Methyl 5-bromo-2-chloropyridine-3-carboxylate

Methyl 5-<WBR>broMo-<WBR>2-<WBR>iodobenzoate

Benzoic acid,5-broMo-2-iodo-, Methyl ester

5-Bromo-2-iodo-benzoic acid methyl ester

5-Bromo-2-iodobenzoate

METHYL 5-BROMMETHYL 5-BROMO-2-IODOBENZOATEO-2-IODOBENZOATE

QCF4

5-bromo-2-iodobenzoate methyl

Methyl 2-Iodo-5-Bromobenzoate

181765-86-6

BrC6H3ICO2CH3

Acids & Esters

Bromine Compounds

Iodine Compounds

C8 to C9

Carbonyl Compounds

Esters