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ChemicalBook > CAS DataBase List > 4-Morpholineethanesulfonic acid

4-Morpholineethanesulfonic acid

Application
Product Name
4-Morpholineethanesulfonic acid
CAS No.
4432-31-9
Chemical Name
4-Morpholineethanesulfonic acid
Synonyms
MES;2-(N-MORPHOLINO)ETHANESULFONIC ACID;2-MORPHOLINOETHANESULFONIC ACID;MES 2-Morpholinoethanesulfonic acid;ME1;TIMTEC-BB;2-(N-Morpholino)ethanesulfonic;4-MORPHOLINOETHANESULFONIC ACID;MKS1;BBS13
CBNumber
CB3100297
Molecular Formula
C6H13NO4S
Formula Weight
195.24
MOL File
4432-31-9.mol
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4-Morpholineethanesulfonic acid Property

Melting point:
>300 °C(lit.)
Boiling point:
102°C
Density 
1.208 (estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 0.5 M at 20 °C, clear
form 
Powder
pka
pKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011
color 
White
PH
2.5-4.0 (25℃ in neat)
PH Range
5.5 - 6.7
Water Solubility 
185.2g/L at 20℃
λmax
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck 
13,5929
BRN 
6350956
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
SXGZJKUKBWWHRA-UHFFFAOYSA-N
LogP
-2.2 at 20℃
CAS DataBase Reference
4432-31-9(CAS DataBase Reference)
EPA Substance Registry System
4-Morpholineethanesulfonic acid (4432-31-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
WGK Germany 
1
RTECS 
QE9104530
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1442
Product name
MOPS solution
Purity
BioPerformance Certified, 1 M, suitable for cell culture
Packaging
100 mL
Price
$56.8
Updated
2025/07/31
Sigma-Aldrich
Product number
M1442
Product name
MOPS solution
Purity
BioPerformance Certified, 1 M, suitable for cell culture
Packaging
500 mL
Price
$167.61
Updated
2025/07/31
Sigma-Aldrich
Product number
M1442
Product name
MOPS solution
Purity
BioPerformance Certified, 1 M, suitable for cell culture
Packaging
1 L
Price
$299.54
Updated
2025/07/31
Sigma-Aldrich
Product number
M1317
Product name
MES solution
Purity
suitable for, BioPerformance Certified, 1?M, suitable for cell culture
Packaging
100ML
Price
$65.4
Updated
2025/07/31
Sigma-Aldrich
Product number
M1317
Product name
MES solution
Purity
suitable for, BioPerformance Certified, 1?M, suitable for cell culture
Packaging
500ML
Price
$188
Updated
2025/07/31
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4-Morpholineethanesulfonic acid Chemical Properties,Usage,Production

Application

4-Morpholineethanesulfonic acid (MES) is one of the good′s buffers, and the most extensively application is biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring and it does not form complexes with the majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. MES has been also used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles and it has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection.

Chemical Properties

White/clear crystalline powder

Uses

MES solution has been used to activate microspheres. It has also been used as a component of activating solution to activate carboxyl groups of poly lactic-co-glycolic acid (PLGA).

Uses

Biological buffer.

Definition

ChEBI: 2-(N-morpholino)ethanesulfonic acid is a Good's buffer substance, pKa = 6.15 at 20 ℃. It is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate.

General Description

MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes.

Flammability and Explosibility

Not classified

storage

Store at RT

Purification Methods

Crystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.]

4-Morpholineethanesulfonic acid Preparation Products And Raw materials

Raw materials

Sodium hypochlorite Sodium sulfite Sulfur trioxide METHYL LAURATE LARD Methyl palmitate

Preparation Products

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View Lastest Price from 4-Morpholineethanesulfonic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Morpholineethanesulfonic acid 4432-31-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
3500kg/month
Release date
2021-09-09
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4-Morpholineethanesulfonic acid 4432-31-9
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-20
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Morpholineethanesulfonic acid 4432-31-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

4432-31-9, 4-Morpholineethanesulfonic acidRelated Search:

Tridemorph Moroxydine Moroxydine hydrochloride Dimethomorph Ethanesulfonic acid Ascoric Acid MES monohydrate 2-methylthioadenosine-5’-o-diphosphate(2-mes-atp),sodiumsal HEPPS MES-K,MES POTASSIUM SALT,2-(N-Morpholino)ethanesulfonic acid potassium salt, 4-Morpholineethanesulfonic acid potassium salt 2-(N-Morpholino)ethanesulfonic acid hemisodium salt MES sodium salt 2-methylthioadenosine-5’-o-triphosphate(2-mes-atp),sodiumsal Methyl ethanesulfonate OVA IN MES 4-Morpholineethanesulfonic acid monohydrate, MES-d13,MES-d13,4-Morpholineethanesulfonic acid monohydrate, MES-d13 MesBuffer 4-Morpholineethanesulfonic acid

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  • 4432-31-9 4-Morpholineethanesulfonic acid MES
  • MES, ≥99%(T),water≤1.0%
  • MES, ≥99.5%(T)