2, 4-DICHLORO-5-IODOPYRIMIDINE
- Product Name
- 2, 4-DICHLORO-5-IODOPYRIMIDINE
- CAS No.
- 13544-44-0
- Chemical Name
- 2, 4-DICHLORO-5-IODOPYRIMIDINE
- Synonyms
- 2,4-Dichloro-5-iodopyrimidine;GS-5894;oro-5-iodopyrimidine;2, 4-dichloro-5-iodimidine;5-Iodo-2,4-dichloropyrimidine;2,4-Dichloro-5-iodo-1,3-diazine;Pyrimidine, 2,4-dichloro-5-iodo-;2,4-Dichloro-5-iodopyrimidine>2,4-Dichloro-5-iodopyrimidine 95%;2,4-Dichloro-5-iodopyriMidine, 95+%
- CBNumber
- CB31009832
- Molecular Formula
- C4HCl2IN2
- Formula Weight
- 274.87
- MOL File
- 13544-44-0.mol
2, 4-DICHLORO-5-IODOPYRIMIDINE Property
- Melting point:
- 68.0 to 72.0 °C
- Boiling point:
- 310.2±22.0 °C(Predicted)
- Density
- 2?+-.0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -4.19±0.29(Predicted)
- color
- White to Gray to Brown
- InChIKey
- RGJNPJRAXMSHKN-UHFFFAOYSA-N
- CAS DataBase Reference
- 13544-44-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 706566
- Product name
- 2,4-Dichloro-5-iodopyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $47.5
- Updated
- 2025/07/31
- Product number
- D4122
- Product name
- 2,4-Dichloro-5-iodopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- D4122
- Product name
- 2,4-Dichloro-5-iodopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $120
- Updated
- 2025/07/31
- Product number
- D434865
- Product name
- 2,4-Dichloro-5-iodopyrimidine
- Packaging
- 10g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- D434865
- Product name
- 2,4-Dichloro-5-iodopyrimidine
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
2, 4-DICHLORO-5-IODOPYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
2,4-Dichloro-5-iodopyrimidine can be used as a reagent to synthesize dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrimidine VLA-4 antagonists.
Synthesis
696-07-1
13544-44-0
The general procedure for the synthesis of 2,4-dichloro-5-iodopyrimidine from 5-iodouracil is as follows: 1. Preparation of intermediate 1: 2,4-dichloro-5-iodopyrimidine - To a suspension of N,N-dimethylaniline (11.0 mL) in 5-iodouracil (10.0 g, 42 mmol), phosphorus oxychloride (POCl3, 64.4 g, 39.2 mL, 420 mmol) was added. - The reaction mixture was heated to 90 °C and stirred at this temperature for 90 min. - After the reaction was completed, it was cooled to room temperature and the excess POCl3 was removed by evaporation. - The residue was slowly poured into an ice-water mixture and stirred for 2 h. The crystalline precipitate was collected by filtration and washed with cold water. - The crude product was dissolved in ethyl acetate and extracted sequentially with aqueous sodium bicarbonate and aqueous sodium sulfite. - The organic phase was dried with anhydrous sodium sulfate, filtered and the solvent was evaporated. - The residue was purified by column chromatography to afford 2,4-dichloro-5-iodopyrimidine (10.6 g, 92% yield). The structure of the product was determined by 1H-NMR. - The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 8.90 (s, 1H).
References
[1] Patent: EP1878726, 2008, A1. Location in patent: Page/Page column 32
[2] Patent: WO2007/71455, 2007, A1. Location in patent: Page/Page column 146
[3] Patent: US2007/232632, 2007, A1. Location in patent: Page/Page column 55; 56
[4] Patent: WO2008/155140, 2008, A1. Location in patent: Page/Page column 108
[5] Tetrahedron, 2000, vol. 56, # 27, p. 4777 - 4792
2, 4-DICHLORO-5-IODOPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2, 4-DICHLORO-5-IODOPYRIMIDINE Suppliers
- Tel
- --
- Fax
- --
- info@generalintermediates.com
- Country
- Canada
- ProdList
- 640
- Advantage
- 38
View Lastest Price from 2, 4-DICHLORO-5-IODOPYRIMIDINE manufacturers
- Product
- 2, 4-DICHLORO-5-IODOPYRIMIDINE 13544-44-0
- Price
- US $36.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 2, 4-DICHLORO-5-IODOPYRIMIDINE 13544-44-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 2, 4-Dichloro-5-Iodopyrimidine 13544-44-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10