ChemicalBook > CAS DataBase List > Ethoxysanguinarine

Ethoxysanguinarine

Product Name: Ethoxysanguinarine
CAS No.: 28342-31-6
Chemical Name: Ethoxysanguinarine
Synonyms: Ethoxysanguinarine;6-Ethoxysanguinarine;6-Ethoxydihydrosanguinarine;Ethoxysanguinarine Stemonine;Ethoxysanguinarine, 10 mM in DMSO;14-Ethoxy-13,14-dihydrosanguinarine;($$+/-$$)-Sanguinarine pseudoethanolate;14-Ethoxy-13,14-dihydrosanguinarine (±)-Sanguinarine pseudoethanolate;[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine, 14-ethoxy-13,14-dihydro-13-methyl-;Ethoxysanguinarine/6-Ethoxysanguinarine/6-Ethoxydihydrosanguinarine/(±)-Sanguinarine pseudoethanolate
CBNumber: CB31130428
Molecular Formula: C22H19NO5
Formula Weight: 377.39
MOL File: 28342-31-6.mol

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Ethoxysanguinarine Property

Melting point:: 210-212℃ (ethanol )
Boiling point:: 563.7±50.0 °C(Predicted)
Density: 1.45±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 4°C, protect from light
solubility: Soluble in DMSO
pka: 0.59±0.40(Predicted)
form: Solid
color: White to yellow
InChI: InChI=1S/C22H19NO5/c1-3-24-22-19-13(6-7-16-21(19)28-11-25-16)14-5-4-12-8-17-18(27-10-26-17)9-15(12)20(14)23(22)2/h4-9,22H,3,10-11H2,1-2H3
InChIKey: FCEXWTOTHXCQCQ-UHFFFAOYSA-N
SMILES: C1=C2C(N(C)C(OCC)C3=C2C=CC2OCOC3=2)=C2C=C3OCOC3=CC2=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0003459
Product name: ETHOXYSANGUINARINE
Purity: 95.00%
Packaging: 5MG
Price: $503.9
Updated: 2021/12/16

AvaChem

Product number: 1780
Product name: Ethoxysanguinarine
Packaging: 10mg
Price: $690
Updated: 2021/12/16

Crysdot

Product number: CD32001749
Product name: 6-Ethoxydihydrosanguinarine
Purity: 95+%
Packaging: 1g
Price: $1955
Updated: 2021/12/16

DC Chemicals

Product number: DCY-165
Product name: Ethoxysanguinarine
Purity: >98%,StandardReferencesGrade
Packaging: 20mg
Price: $280
Updated: 2021/12/16

Arctom

Product number: CFN89308
Product name: 6-Ethoxydihydrosanguinarine
Purity: ≥98%
Packaging: 5mg
Price: $318
Updated: 2021/12/16

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Ethoxysanguinarine Chemical Properties,Usage,Production

Uses

Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1].

in vivo

Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice^[1].

Animal Model:	Nude immunodeficient mice (5-week-old, weighing about 16 g)^[1]
Dosage:	0.5 mg/kg
Administration:	Subcutaneous injection; 5 times per week for 4 weeks
Result:	Exhibited antitumor effects without reduce the body weight of the mice.

References

[1] Jin L, et al. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A. Int J Oncol. 2018 Mar 16. DOI:10.3892/ijo.2018.4323

Ethoxysanguinarine Preparation Products And Raw materials

Raw materials

Preparation Products

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28342-31-6, EthoxysanguinarineRelated Search:

Diethylene Glycol Monoethyl Ether SANGUINARINE CHLORIDE(RG) Acetyl chloride ALLOCRYPTOPINE DIHYDROSANGUINARINE 6-Methoxydihydrosanguinarine Dihydrochelerythrine 6-Methoxyldihydrochelerythrine chloride Chelerythrine Sophocarpine angoline Swertiamarine Macleaya cordata extract Ethoxysanguinarine SANGUINARINE CHLORIDE SANGUINARINE Nitidine chloride fagaronine

Ethoxysanguinarine

($$+/-$$)-Sanguinarine pseudoethanolate

14-Ethoxy-13,14-dihydrosanguinarine

14-Ethoxy-13-Methyl-13,14-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine

14-Ethoxy-13,14-dihydrosanguinarine (±)-Sanguinarine pseudoethanolate

6-Ethoxysanguinarine

6-Ethoxydihydrosanguinarine

Ethoxysanguinarine Stemonine

Ethoxysanguinarine/6-Ethoxysanguinarine/6-Ethoxydihydrosanguinarine/(±)-Sanguinarine pseudoethanolate

PP2A,colorectal cancer cells,protein phosphatase 2A,Apoptosis,cancerous inhibitor of protein phosphatase 2A,CIP2A,inhibit,benzophenanthridine,Ethoxysanguinarine,Inhibitor

[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine, 14-ethoxy-13,14-dihydro-13-methyl-

Ethoxysanguinarine, 10 mM in DMSO

28342-31-6

reagent

standard substance